 | | Vol. 9.34 – 8 September, 2021 |
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| Researchers found that the emergence of these three “501Y lineages” coincided with a major global shift in the selective forces acting on various SARS-CoV-2 genes.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors demonstrated that both humoral and cellular adaptive immunity contribute to viral clearance in the setting of primary infection.
[Science Immunology] |
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| Scientists tested the sensitivity and performance of a simple and rapid SARS-CoV-2 spike protein–specific T cell test based on the stimulation of whole blood with peptides covering the SARS-CoV-2 spike protein, followed by cytokine measurement in different cohorts.
[Journal of Clinical Investigation] |
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| Investigators identified that coronavirus induced an increased macrophage-mediated inflammatory response due to a coronavirus-induced decrease in the histone methyltransferase, SETDB2.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers showed that lysates prepared from macrophage-like cell lines and primary macrophages robustly induced C. albicans filamentation.
[Cell Reports] |
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| A novel SARS-CoV-2 receptor-binding domain (RBD) homodimer was developed as a SARS-CoV-2 vaccine candidate. Formulated with aluminum adjuvant, RBD dimer elicited strong immune response in both rodents and non-human primates.
[Cell Discovery] |
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| Scientists reported the discovery of ethacridine as a potent drug against SARS-CoV-2. Ethacridine was identified via high-throughput screening of an FDA-approved drug library in living cells using a fluorescence assay.
[PLOS Pathogens] |
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| Transporters in the human liver play a major role in the clearance of endo- and xenobiotics. Researchers examined the in vitro interactions of some key repurposed drugs advocated to treat COVID-19 with the key drug transporters of hepatocytes.
[Scientific Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| To address mechanisms of durable and aborted control of viremia, investigators evaluated immunologic and virologic parameters longitudinally among 34 HIV-infected subjects with differential outcomes.
[Immunity] |
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| The authors showed that the Shigella ubiquitin ligase IpaH7.8 functioned as an inhibitor of the pore-forming protein gasdermin.
[Cell Host & Microbe] |
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| Scientists review the emerging evidence that supports the existence of such a population of circulating resident memory T cell progenitors, discuss current insights into their formation and highlight open questions in the field.
[Nature Reviews Immunology] |
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| The authors provide important information for the development of effective neutralizing antibodies with broad-spectrum activity against current and future SARS-CoV-2 strains.
[Cellular & Molecular Immunology] |
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| The use of the quantitative reverse transcriptase polymerase chain reaction for detection of the viral nucleic acid remains the most valuable in terms of its specificity, fast turn-around, high-throughput capacity, and reliability. It is critical to update the sequences of primers and probes to ensure the detection of newly emerged variants.
[Laboratory Investigation] |
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| Exscientia announced a four year collaboration with the Bill & Melinda Gates Foundation to develop small molecule therapeutics that tackle the current coronavirus pandemic and help prepare for future pandemics.
[Exscientia] |
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| Sorrento Therapeutics, Inc. announced the start of enrollment in its Phase II efficacy study of human allogeneic adipose-derived mesenchymal stem cells for patients suffering from COVID-19-induced acute respiratory distress or acute respiratory distress syndrome in Brazil.
[Sorrento Therapeutics, Inc.] |
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| October 27 – 29, 2021
Virtual |
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| | University of Miami – Miami, Florida, United States |
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| University of Colorado – Aurora, Colorado, United States |
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| University of North Dakota – Grand Forks, North Dakota, United States |
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| | Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom |
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| | Cleveland Clinic – Port Saint Lucie, Florida, United States |
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