Immunology of Infectious Disease News Volume 9.37 | Sep 29 2021

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    2021-09-29 | IIDN 9.37


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 9.37 – 29 September, 2021
    TOP STORY

    Correlates of Protection against Symptomatic and Asymptomatic SARS-CoV-2 Infection

    Binding and neutralizing antibodies at 28 days after the second dose of the hAdOx1 nCoV-19 vaccine were measured in infected and noninfected vaccine recipients.
    [Nature Medicine]

    Full Article

    Studying COVID-19 with ALI culture
    PUBLICATIONSRanked by the impact factor of the journal

    SARS-CoV-2 Infection Causes Immunodeficiency in Recovered Patients by Downregulating CD19 Expression in B Cells via Enhancing B-Cell Metabolism

    Researchers characterized the immune phenotype of B cells from 15 recovered COVID-19 patients, and found that healthy controls and recovered patients had similar B cell populations before and after BCR stimulation.
    [Signal Transduction and Targeted Therapy]

    Full Article

    A Potent SARS-CoV-2 Neutralising Nanobody Shows Therapeutic Efficacy in the Syrian Golden Hamster Model of COVID-19

    Scientists reported four nanobodies engineered as homotrimers with pmolar affinity for the receptor binding domain of the SARS-CoV-2 spike protein.
    [Nature Communications]

    Full Article

    Cross-Neutralizing Antibodies Bind a SARS-CoV-2 Cryptic Site and Resist Circulating Variants

    Investigators obtained two cross-neutralizing antibodies that target Sarbecoviruses’ receptor-binding domain with sub-picomolar affinities and potently neutralize authentic SARS-CoV-2.
    [Nature Communications]

    Full Article

    Adverse Events after SARS-CoV-2 mRNA Vaccination Among Patients with Inflammatory Bowel Disease

    The authors evaluated adverse events after messenger RNA (mRNA) vaccination in 246 adults with inflammatory bowel disease participating in a longitudinal vaccine registry.
    [American Journal of Gastroenterology]

    Abstract

    A Highly Potent Antibody Effective against SARS-CoV-2 Variants of Concern

    Investigators screened B cells from COVID-19 donors and identify P5C3, a highly potent and broadly neutralizing monoclonal antibody with picomolar neutralizing activity against all SARS-CoV-2 variants of concern identified to date.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Dynamics of TCR Repertoire and T Cell Function in COVID-19 Convalescent Individuals

    Researchers presented both single-cell TCR-seq and RNA-seq to analyze the dynamics of TCR repertoire and immune metabolic functions of blood T cells collected from recently discharged COVID-19 patients.
    [Cell Discovery]

    Full Article

    Predictors of Humoral Response to SARS-CoV-2 Vaccination after Hematopoietic Cell Transplantation and CAR T Cell Therapy

    Scientists analyzed anti-SARS-CoV-2 spike IgG antibody titers and neutralizing Ab among 217 recipients of cellular treatments, such as allogeneic and autologous hematopoietic cell transplant and chimeric antigen receptor T cell therapy.
    [Blood Cancer Discovery]

    Abstract

    ER Stress Promotes HBV Production by Enhancing Utilization of the Autophagosome- Multivesicular Body Axis

    Investigators studied the effect of tunicamycin, an N-glycosylation inhibitor and endoplasmic reticulum (ER) stress inducer, on hepatitis B virus replication and secretion, and examined the underlying mechanisms.
    [Hepatology]

    Abstract

    Curcumin Inhibited Hepatitis B Viral Entry through NTCP Binding

    Curcumin was investigated for inhibitory action toward hepatitis B virus attachment and internalization.
    [Scientific Reports]

    Full Article

    The Immunology Podcast is here. Find it wherever you get your podcasts.
    REVIEWS

    ACE2 Function in Pancreatic Islet: Implications for Relationship between SARS-CoV-2 and Diabetes

    Given the ability of SARS-COV-2 to infect human pluripotent stem cell-derived pancreatic cells in vitro and the presence of SARS-CoV-2 in pancreatic samples from COVID-19 patients strongly hints that SARS-CoV-2 can invade the pancreas and directly cause pancreatic injury and diabetes.
    [Acta Physiologica]

    Full Article

    Microscale Communication between Bacterial Pathogens and the Host Epithelium

    Scientists discuss several examples of this form of microscale communication between bacterial pathogens and mammalian host cells and try to delineate their downstream ramifications in the infection process.
    [Genes & Immunity]

    Full Article

    INDUSTRY AND POLICY NEWS

    ANP Technologies, Inc. Receives FDA EUA Authorization for its NIDS® COVID-19 Antigen Rapid Test Kit

    ANP Technologies, Inc. announced that it has received Emergency Use Authorization for its NIDS® COVID-19 Antigen Rapid Test Kit from the FDA.
    [ANP Technologies, Inc. (BusinessWire, Inc.)]

    Press Release

    Pfizer Starts Study of mRNA-Based Next Generation Flu Vaccine Program

    Pfizer, Inc. announced that the first participants have been dosed in a Phase I clinical trial to evaluate the safety, tolerability, and immunogenicity of a single dose quadrivalent mRNA vaccine against influenza in healthy adults.
    [Pfizer, Inc.]

    Press Release

    FEATURED EVENT

    AACR Virtual Special Conference: Tumor Immunology and Immunotherapy

    October 5 – 6, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Immunoinformatician – Next Generation Vaccines against Infectious Diseases

    Vaccibody AS – Oslo, Norway

    GlaxoSmithKline Professorship – Microbial Pathogenesis

    University of Cambridge – Cambridge, England, United Kingdom

    Division Director – Infectious Diseases

    Vanderbilt University Medical Center – Nashville, Tennessee, United States

    Faculty Positions – Infectious Diseases

    Cleveland Clinic – Port Saint Lucie, Florida, United States

    Assistant Professor – Immunology, Microbiology of Skin and Vaginal Mucosa

    University of Colorado – Aurora, Colorado, United States

    > See All Jobs

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