 | | Vol. 9.41 – 27 October, 2021 |
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| Scientists uncovered important roles of enteric glial cells in intestinal homeostasis, immunity and tissue repair. They demonstrated that infection of mice with Heligmosomoides polygyrus led to enteric gliosis and the upregulation of an interferon gamma gene signature.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Following boost, animals had increased neutralizing antibody responses across all variants of concern, which was sustained for at least eight weeks post-boost.
[Science] |
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| Investigators reported the structure, function, and antigenicity of the SARS-CoV-2 Delta variant’s full-length spike trimer and those of the Gamma and Kappa variants and compared their characteristics with the G614, Alpha, and Beta variants.
[Science] |
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| The authors described a COVID-19 vaccine based on a replication-defective gorilla adenovirus expressing the stabilized pre-fusion SARS-CoV-2 spike protein, named GRAd-COV2.
[Science Immunology] |
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| Investigators employed a multi-omics analysis combined with artificial intelligence in a young patient cohort where major comorbidities were excluded at the onset.
[Science Immunology] |
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| Researchers compared variants of concern B.1.1.7 and B.1.351 to a recent B.1 SARS-CoV-2 isolate containing the D614G spike substitution in the rhesus macaque model. B.1.1.7 behaved similarly to D614G with respect to clinical disease and replication in the respiratory tract.
[Science Advances] |
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| The authors evaluated systemic and mucosal immune signatures in asymptomatic SARS-CoV-2–infected versus symptomatic COVID-19 adults compared with respiratory syncytial virus-infected adults.
[Science Advances] |
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| Investigators developed a COVID-19 vaccine candidate based on Newcastle disease virus that could be manufactured at high yields in embryonated eggs.
[Nature Communications] |
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| To combat SARS-CoV-2, researchers characterized a temperature-stable vaccine candidate that used a replication-competent, attenuated vaccinia virus as a vector to express a membrane-tethered spike receptor binding domain (RBD) antigen.
[Molecular Therapy] |
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| The authors found that SARS-CoV-2 manipulated the antiviral and immune responses. They validated that the membrane protein ITGB1 associated angiotensin-converting enzyme 2 (ACE2) to mediate SARS-CoV-2 entry.
[Cell Chemical Biology] |
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| Scientists reported, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine.
[Cell Discovery] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors demonstrated that Mycobacterium tuberculosis infection triggered a time-dependent reduction in the expression of focal adhesion kinase in human macrophages.
[Frontiers in Imm] |
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| Investigators analyzed the antiviral efficacy of drug candidates of a novel compound class of HPIs for the treatment of HSV type 1 to identify the most active eutomer structure in an intranasal infection mouse lethal challenge model.
[Antiviral Research] |
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| Six HLA MHC-I allele B*07:02 (HLA-B7)-restricted CD8+ T cell epitopes were identified using ELISPOT screening in the F, M, and N proteins, with M195–203 (M195) eliciting the strongest responses.
[Scientific Reports] |
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| Researchers compared innate immune responses in the lungs of healthy colonized and non-colonized mice after Influenza A virus challenge at the initial asymptomatic stage of infection.
[Scientific Reports] |
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| To evaluate anti-inflammatory activities of L. reuteri LM1071, lipopolysaccharides-stimulated RAW264.7 cells were used. Gene expression levels of eight immune-associated genes including IL-1β, IL-6, and TNF-α and protein production levels of COX-1 and COX-2 were analyzed.
[Journal of Applied Microbiology] |
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| There is little known about risk factors or predictors of susceptibility for Long-Hauler’s Syndrome, but older adults are at greater risk for severe outcomes and mortality from COVID-19.
[Translational Research] |
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| Owing to antiviral, anti-inflammatory, immunomodulatory, and cardioprotective activity, statin therapy has been considered as valuable tool to improve COVID-19 outcomes.
[Lipids in Health and Disease] |
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| While denying once again it had helped create the virus that sparked the COVID-19 pandemic, the US National Institutes of Health (NIH) revealed in a letter sent to Republicans in Congress that experiments it funded through a US-based nonprofit in 2018 and 2019 at the Wuhan Institute of Virology in China had the “unexpected result” of creating a coronavirus that was more infectious in mice.
[ScienceInsider] |
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| Moderna, Inc. announced Swissmedic has authorized a booster dose of Spikevax, the company’s vaccine against COVID-19, at the 50 µg dose level in particularly vulnerable individuals 12 years of age and older, at least six months after completion of the primary series.
[Moderna, Inc.] |
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| November 23 – 26, 2021
Ibaraki, Japan & Online |
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| | Francis Crick Institute – London, United Kingdom |
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| | Malmö, Sweden – Lund University |
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| | Helmholtz Zentrum München – Augsburg, Germany |
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| | University of Pittsburgh Graduate School of Public Health – Pittsburgh, Pennsylvania, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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