 | | Vol. 4.30 – 10 November, 2021 |
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| The authors showed that Kappa and Delta variants dampen the in vitro potency of vaccine-elicited serum neutralizing antibodies and provide a structural framework for describing their immune evasion.
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using wild-type and human ACE2 knock-in mouse models, investigators found a single dose of rVSV-SARS-CoV could elicit strong humoral immune response via both intranasal and intramuscular routes.
[Signal Transduction and Targeted Therapy] |
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| Researchers revealed that the receptor-binding domain of the spike protein on SARS-CoV-2 recognized oligosaccharides containing sialic acid, with preference for monosialylated gangliosides.
[Nature Chemical Biology] |
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| Investigators showed that O-glycosylation near the furin cleavage site was mediated by members of the GALNT enzyme family, resulting in decreased furin cleavage and decreased syncytia formation.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors targeted white-tailed deer for serosurveillance based on evidence these deer have angiotensin-converting enzyme 2 receptors with high affinity for SARS-CoV-2.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors reported a series of ten COVID-19 patients with audiovestibular symptoms such as hearing loss, vestibular dysfunction and tinnitus.
[Scientific Reports] |
| | Scientists evaluated novel protein subunit vaccine formulations containing a resistin-trimerized spike antigen, SmT1.
[Communications Medicine] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Hepatitis B virus infected HepG2-NTCP were treated with tenofovir disoproxil fumarate, Toll-like receptor 7/8 agonists, TLR7/8 conditioned media collected from immune cells, or RNA interference using short-interfering RNAs.
[Hepatology] |
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| The authors showed that effective induction of T cell responses against influenza A virus in mice requires reinforcement of the resident lung conventional dendritic cells (cDC) network by cDC progenitors.
[Science Immunology] |
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| Investigators reported that cold shock protein (Csp)C—but not CspE— was necessary to activate the master virulence regulator PhoP when Salmonella enterica serovar Typhimurium experienced mildly acidic pH, such as inside macrophages.
[Nucleic Acids Research] |
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| Invariant natural killer T (iNKT) cells from peripheral blood and colonic mucosa were investigated during treated and untreated acute HIV-1 infection.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists demonstrated that a modular trimerization domain known as the molecular clamp allows the efficient production and purification of conformationally stabilised prefusion hemagglutinin from a diverse range of influenza A subtypes.
[NPJ Vaccines] |
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| Researchers evaluated the effect of imipenem and ceftriaxone on neutrophil extracellular traps (NETs) formation in vitro and examined the role of reactive oxygen species.
[Cell Death Discovery] |
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| Scientists investigated the expression of FOXP3+ Treg cells in leprosy skin lesions and correlated their clinical forms, laboratory characteristics, and the immune reconstitution syndrome in HIV-leprosy co-infection.
[PLoS Neglected Tropical Diseases] |
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| Investigators review current knowledge of aberrant immune responses during sepsis and recent initiatives to stratify patients with sepsis into subgroups that are more alike from a clinical and/or pathobiological perspective.
[Immunity] |
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| Scientists performed a systematic review of clinical studies investigating different types of stem cells as treatments for COVID-19 and ARDS to evaluate the safety and potential efficacy of cell therapy.
[NPJ Regenerative Medicine] |
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| Opening a new chapter in the treatment of COVID-19—one borrowed from successfully tackling the AIDS virus—the drug behemoth Pfizer reported upbeat results for a 5-day pill regimen to treat early infections with SARS-CoV-2.
[ScienceInsider] |
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| SCYNEXIS, Inc. announced the successful completion of a Phase I clinical study to evaluate the safety, tolerability and pharmacokinetics of a liposomal intravenous formulation of ibrexafungerp in healthy subjects.
[SCYNEXIS, Inc.] |
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| November 29 – December 1, 2021
Barcelona, Spain |
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| | Pfizer – New York City, New York, United States |
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| | City of Hope – Duarte, California, United States |
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| Stanford University – Stanford, California, United States |
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| | Francis Crick Institute – London, United Kingdom |
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| | Lund University РMalm̦, Sweden |
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