 | | Vol. 9.47 – 1 December, 2021 |
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| The authors assessed the immunogenicity and protective activity of historical or modified Moderna mRNA vaccines in 129S2 and K18-hACE2 mice.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists described the use of an inhalation tower system that allowed exposure of unanesthetized mice to aerosolized virus under controlled conditions.
[Science Immunology] |
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| To identify early predictors of mortality within 60 days of symptom onset, researchers performed immunovirological assessments on plasma from 279 individuals.
[Science Advances] |
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| The authors performed deep profiling of SARS-CoV-2-specific antibody titer, Fc-receptor binding, and Fc-mediated functional assays in convalescent plasma (CP) units, as well as in plasma from hospitalized COVID-19 patients before and after CP administration.
[Nature Communications] |
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| Investigators reported that intranasal vaccinations with adenovirus 5 and 19a vectored vaccines following a systemic plasmid DNA or mRNA priming resulted in systemic and mucosal immunity in mice.
[Nature Communications] |
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| Scientists exploited the immunostimulatory properties of bacille Calmette-Guérin, the existing tuberculosis vaccine, to deliver a vaccination regimen with potent SARS-CoV-2-specific protective immunity.
[NPJ Vaccines] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers identified that targeting the epigenetic modifier BMI-1 in mice improved humoral responses to chronic lymphocytic choriomeningitis virus.
[Nature Immunology] |
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| The authors reported that RORC2 was a key host cofactor for HIV replication in Th17 cells and found that specific inhibitors that bound to the RORC2 ligand-binding domain reduced HIV replication in CD4+ T cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators used RNA sequencing to determine that HIV-1 alone induced few or no signs of an type I interferon response in THP-1 cells.
[mBio] |
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| Upon influenza A virus (IAV) challenge, scientists found that cells escaping viral infection display increased mRNA expression of type-I interferon stimulated genes and decreased expression of ribosomal genes, relative to both infected cells and those never exposed to IAV.
[Frontiers in Immunology] |
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| Researchers utilized the biotin ligase -TurboID fusion with Toxoplasma gondii surface antigen 1 (TgSAG1) to identify the host proteins interacting with TgSAG1, and identified that S100A6 was co-localized with TgSAG1 when T. gondii attached to the host cell.
[iScience] |
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| Single-gene inborn errors of cell-intrinsic or leukocytic immunity underlying diverse infections in the skin, brain, or lungs can help to clarify the human determinants of viral disease.
[Science] |
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| Scientists discuss novel latency-reversing agents targeting dendritic cells (DCs) as well as DC-based strategies to enhance the clearance of infected cells by CD8+ T cells and strategies to improve the killing activity of natural killer cells.
[Nature Reviews Immunology] |
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| The authors focus on the important signaling pathways, potential molecular mechanism, and pathway-associated therapy in sepsis.
[Signal Transduction and Targeted Therapy] |
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| Pfizer, Inc. announced that the Committee for Medicinal Products (CHMP) for Human Use of the European Medicines Agency issued a positive opinion on the administration of the companies’ COVID-19 vaccine COMIRNATY® in children 5 to under 12 years of age.
[Pfizer, Inc.] |
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| January 16 – 20, 2022
Banff, Alberta, Canada |
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| | King’s College London – London, England, United Kingdom |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | University Medical Center Freiburg – Freiburg, Germany |
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| | The Henry M. Jackson Foundation for the Advancement of Military Medicine – Silver Spring, Mayland, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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