 | | Vol. 10.21 – 25 May, 2022 |
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| The authors described patients with haploinsufficiency for the linear deubiquitinase OTULIN, encoded by a gene on chromosome 5p.
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers analyzed humoral and cellular immunity against an early-pandemic viral isolate and compare that to the P.1 and B.1.617.2 variants in two cohorts of mRNA vaccine recipients.
[Nature Communications] |
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| SARS–CoV-2–infected Casp11−/− mice were protected from severe weight loss and lung pathology, including blood vessel damage, compared to wild-type mice and mice lacking the caspase downstream effector gasdermin-D.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Vaccination induced greater antibody titers in older females than males, with both age and frailty associated with reduced antibody responses in males, but not females.
[Clinical Infectious Diseases] |
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| Scientists designed a prospective Italian multicentrer study to assess humoral and T-cell responses to SARS-CoV-2 vaccination in patients with solid tumors, hematological malignancies, neurological disorders and immunorheumatological diseases.
[Clinical Infectious Diseases] |
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| The authors tested the effect of two probiotic consortia, OL-1 and OL-2, against SARS-CoV-2 in ferrets and assessed their effect on cytokine production and transcriptome in a human monocyte-derived macrophage and dendritic cell model.
[iScience] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| During acute Zika virus infection, scientists identified widely coordinated responses across innate and adaptive immune cell lineages.
[Cell Reports] |
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| Investigators identified and compared the pathological, cellular, and functional differences in granulomas at 4, 12, and 20 weeks post-infection in Chinese cynomolgus macaques.
[Cell Reports] |
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| Scientists evaluated CD4+ T cell responses in infants exposed to HIV and uninfected who received Bacille Calmette-Guérin (BCG) at birth and examined their role in susceptibility to Mycobacterium tuberculosis infection and influence on tuberculin skin test induration.
[Ebiomedicine] |
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| The authors found that the CD14+CD16high intermediate monocyte subset from dengue patients highly upregulated key genes involved in mediating inflammation, endothelial dysfunction, vascular permeability, tissue extravasation, and clot prevention compared to healthy children.
[iScience] |
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| Researchers investigated the potential discriminatory role of polychromatic flow cytometry of M. tuberculosis antigen-specific T cells to discriminate smear negative TB from health controls with or without latent TB infection, and non-TB respiratory illnesses in an endemic setting.
[Clinical & Experimental Immunology] |
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| The authors highlight how the strength of the existing global virology and immunology networks built for HIV vaccine research enabled rapid adaptation of techniques, assays, and skill sets, to expeditiously respond to the SARS-CoV-2 pandemic.
[Immunological Reviews] |
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| While there has been extensive research on the latent reservoir of treated patients with chronic HIV-1, which prevents the discontinuation of treatment, the mechanism behind this remains elusive and needs further investigation.
[Current Opinion in Immunology] |
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| Encouraged by the popularity of at-home tests for COVID-19, self-testing has been embraced by many, including policymakers and people in marginalized populations.
[Nature News] |
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| Overall, the number of pandemic-related papers appears set to decline this year, after explosive and unprecedented growth in 2020 and 202.1
[ScienceInsider] |
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| June 12 – 16, 2022
Keystone Symposia, Colorado, United States |
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| | National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | The Walter and Eliza Hall Institute – Parkville, Australia |
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| | Karolinska Institute – Stockholm, Sweden |
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| | Francis Crick Institute – London, England, United Kingdom |
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