 | | Vol. 11.10 – 15 March, 2023 |
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| To identify the mechanisms that drive immune cell recruitment in the lung during viral respiratory infections, researchers studied preclinical murine models of influenza A virus and SARS-CoV-2 infection.
[European Respiratory Journal] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists discovered that antibodies against specific chemokines were omnipresent post-COVID-19, were associated with favorable disease outcome, and negatively correlated with the development of long COVID at one year post-infection.
[Nature Immunology] |
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| The authors characterized the temporal trajectory of blood epigenetic remodeling in 133 participants in a prospective study of young adults before, during, and after asymptomatic and mildly symptomatic SARS-CoV-2 infection.
[Molecular Systems Biology] |
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| Investigators used a deep phenotyping approach to examine immunologic responses in an individual with MIS-A. The findings revealed systemic inflammatory changes involving novel neutrophil and B-cell subsets, autoantibodies, complement, and hypercoagulability that are linked to systemic vascular dysfunction.
[Frontiers In Immunology] |
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| To assess the cellular and electrophysiological effects of direct SARS-CoV-2 infection of the heart, researchers studied human induced pluripotent stem cell-derived cardiomyocytes.
[PLOS One] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Investigators identified itaconate as an orthosteric agonist of the GPCR OXGR1, with an EC50 of approximately 0.3 mM, which was in the same range as the physiological concentration of extracellular itaconate upon macrophage activation.
[Journal Of Clinical Investigation] |
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| 28 people living with HIV-1 on suppressive antiretroviral therapy were randomized to receive pyrimethamine, valproic acid, both, or no intervention for 14 days, in order to investigate the impact of the BAF complex inhibitor pyrimethamine of the latent HIV-1 reservoir.
[Science Advances] |
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| A small-molecule inhibitor of polymerase-associated factor 1 complex (PAF1C) enhanced the activity of diverse HIV-1 latency reversal agents both in cell line latency models and in primary cells from persons living with HIV-1.
[Science Advances] |
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| Among the costimulatory ligands the authors evaluated, MAdCAM-1 was unique in its capacity to upregulate both CCR5 and CCR9. MAdCAM-1 costimulation rendered cells susceptible to HIV infection.
[PLOS Pathogens] |
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| Scientists summarize our growing knowledge of macrophage diversity, how macrophage subsets orchestrate tissue development and function, and further interrelate macrophage ontogeny with their core functions across tissues — that is, the signaling events within the macrophage niche that may control organ functionality during development, homeostasis and aging.
[Nature Reviews Immunology] |
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| The authors analyzed the main results of the recent literature assessing immune response to SARS-CoV-2 over the pediatric age group, summarizing such observations by dividing them into innate and acquired immunity, then reporting how altered immune responses can determine post-infectious conditions.
[Pediatric Research] |
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| Politicians acknowledged that the question of where the SARS-CoV-2 coronavirus originated is highly politicized. But they said that both hypotheses describing its emergence — one, that it spread naturally from animals to people; the other, that it leaked from a laboratory in Wuhan, China — must be explored.
[Nature News] |
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| Researchers from the University of Sydney have been awarded $47 million to support 32 research projects, including investigations of younger-onset dementia, the treatment of blinding eye diseases through stem cell therapy, and the impact of e-cigarette use by adolescents.
[The University of Sydney] |
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| April 16 – 19, 2023
Snowbird, Utah, United States |
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| | Ume̴ University РUme̴, Sweden |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | Cornell University – Ithaca, New York, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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