 | | Vol. 11.07 – 22 February, 2023 |
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| Studying CD8+ T cell differentiation in mice with chronic viral infection, the authors identified the alarmin interleukin-33 as pivotal for the expansion and stem-like functioning of stem-like CD8+ T cells, as well as for virus control.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists re-examinerd public health recommendations regarding the COVID-19 vaccine target groups and timing of the doses, through a mathematical model of SARS-CoV-2 infection in England.
[Nature Communications] |
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| Researchers combined advanced imaging and spatial transcriptomics to shed light on the local immune response in severe COVID-19, and showed that activated adventitial niches are crucial microenvironments contributing to the orchestration of prolonged lung immunopathology.
[Nature Communications] |
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| Investigators reported humanized ACE2-floxed mice in which hACE2 was expressed in a manner that confered lethal disease and permitted cell-specific, Cre-mediated loss of function, and LSL-hACE2 mice in which hACE2 was expressed enabling cell-specific, Cre-mediated gain of function.
[Plos Biology] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists evaluated the frequency of simian immunodeficiency virus (SIV)-infected cells for four years of antiretroviral therapy (ART). The intact proviral DNA assay and an assay for hypermutated proviruses revealed short- and long-term infected cell dynamics in macaques starting ART ∼one year after infection.
[Cell Host & Microbe] |
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| The authors found bifunctional compounds with HIV-1–infected cell kill potency at clinically achievable concentrations. These targeted activator of cell kill molecules resulted in HIV-1+ cell death through premature intracellular viral protease activation.
[Science Translational Medicine] |
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| Scientists investigated the antibiotic and immunological activity of the anticancer agent mitoxantrone in vitro and in vivo against vancomycin-resistant Enterococcus faecalis.
[Science Advances] |
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| Researchers demonstrated that the wild-derived inbred castaneous mouse provided an exceptional animal model for investigating clade differences in mpox virus virulence, and showed that the order is clade I > clade IIa > clade IIb.1.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors demonstrated that toll-like receptor 4 agonist Glucopyranosyl lipid adjuvant in a squalene oil-in-water emulsion improved inactivated, bivalent filovirus/rabies virus vaccine efficacy in a murine model by activating the innate immune system and shaping a Th1-biased adaptive immune response.
[Npj Vaccines] |
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| The authors identified, reviewed, and extracted from the scientific literature retrospective and prospective cohort studies and test-negative case-control studies published from inception up to Sept 31, 2022, that estimated the reduction in risk of COVID-19 among individuals with a past SARS-CoV-2 infection in comparison to those without a previous infection.
[Lancet] |
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| A 53-year-old man in Germany has become at least the third person with HIV to be declared clear of the virus after a procedure that replaced his bone marrow cells with HIV-resistant stem cells from a donor.
[Nature News] |
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| The Howard Hughes Medical Institute’s Emerging Pathogens Initiative, which is pulling in 70 scientists from 29 organizations, will include seven Boston University (BU) researchers, who will be part of teams working on the next generation of RNA-based antiviral therapies and investigating microscopic pathogenic parasites called protozoa.
[The Brink (Boston University)] |
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| March 19 – 23, 2023
Banff, Alberta, Canada |
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| | The University of Melbourne – Melbourne, Australia |
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| | Twincore GmbH – Hannover, Germany |
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| | Helmholtz Centre for Infection Research – Braunschweig, Germany |
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| | The University of Konstanz – Konstanz, Germany |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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