Intestinal Cell News Volume 1.35 | Nov 20 2015

Targeting LGR5⁺ Cells with an Antibody-Drug Conjugate for the Treatment of Colon Cancer
Scientists evaluated a strategy that targets the cell surface leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), a well-characterized tissue stem cell and cancer stem cell marker, with an antibody conjugated to distinct cytotoxic drugs. [Sci Transl Med] Abstract

Divalent Metal-Ion Transporter 1 Is Decreased in Intestinal Epithelial Cells and Contributes to the Anemia in Inflammatory Bowel Disease
Researchers investigated expression of divalent metal-ion transporter 1 (DMT1) in the intestinal mucosa by quantitative real-time polymerase chain reaction and immunohistochemistry, and found that DMT1 was significantly decreased in the inflamed mucosa of active inflammatory bowel disease patients compared with that in those patients at remission stage and healthy controls. [Sci Rep] Full Article

Hydroxytyrosol, a Product from Olive Oil, Reduces Colon Cancer Growth by Enhancing Epidermal Growth Factor Receptor Degradation
The authors studied the effects and mechanism of 2-(3,4-dihydroxyphenil)ethanol (hydroxytyrosol), a polyphenol from extra-virgin olive oil, investigating the regulation of epidermal growth factor receptor expression in colon tumor cells. [Mol Nutr Food Res] Abstract

Inflammation Controls Sensitivity of Human and Mouse Intestinal Epithelial Cells to Galectin-1
Intestinal epithelial cells isolated from mice or patients with inflammatory bowel diseases were incubated with different pro-inflammatory cytokines, and galectin-1 binding, secretion of homeostatic factors and viability were assessed. [J Cell Physiol] Abstract

BAG3 Regulates Cell Proliferation, Migration, and Invasion in Human Colorectal Cancer
Researchers demonstrated that Bcl2-associated athanogene 3 (BAG3) overexpression plays a critical role in cell proliferation, migration, and invasion of colorectal cancer. [Tumor Biol] Abstract

Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells
Researchers investigated the effects of luteolin on colon cancer cells, focusing on the balance between ceramide and sphingosine-1-phosphate, two sphingoid mediators with opposite roles on cell fate. [PLoS One] Full Article

Eukaryotic Translation Initiation Factor 5A2 (eIF5A2) Regulates Chemoresistance in Colorectal Cancer through Epithelial Mesenchymal Transition
The authors investigated whether eIF5A2 was involved in the chemoresistance to doxorubicin in colorectal cancer. They found that eIF5A2-negative colon cancer cells (HCT116 and HT29) were more sensitive to doxorubicin compared with the eIF5A2-positive cells [Cancer Cell Int] Full Article

INTESTINAL STEM CELL & ORGANOID RESEARCH

Aneuploidy Causes Premature Differentiation of Neural and Intestinal Stem Cells
Aneuploid neural stem cells presented an extended G1 phase, which led to cell cycle exit and premature differentiation. Scientists showed that this response to aneuploidy was also present in adult intestinal stem cells but not in the wing disc. [Nat Commun] Full Article | Video

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Immune Pharmaceuticals Announces Enrollment of the First Patient into the Phase II Clinical Trial with Bertilimumab in Ulcerative Colitis
Immune Pharmaceuticals Inc. announced that the first patient has been enrolled into the Phase II clinical trial evaluating the safety and efficacy of its first in class fully human monoclonal antibody, bertilimumab in ulcerative colitis. [Immune Pharmaceuticals, Inc.] Press Release

New Sean N. Parker Autoimmune Research Laboratory is Launched at UCSF
A $10 million gift from The Parker Foundation, founded by Silicon Valley entrepreneur and philanthropist Sean Parker, will establish a new research laboratory within the Diabetes Center at UC San Francisco devoted to understanding autoimmunity, in the hopes of laying the groundwork for new treatments for diseases ranging from type 1 diabetes to multiple sclerosis to rheumatoid arthritis. [University of California San Francisco (UCSF)] Press Release

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NEW Faculty Position – Autoimmune Disease and Rheumatologic Inflammation (Cleveland Clinic)

Research Associate – Intestinal Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Fellowship – Innate Lymphoid Cell-Epithelial Cell Interactions in Intestinal Lymphoid Follicles (Linköping University)

PhD Studentships – Cancer Research (Institute of Cancer Research)

Computational Postdoctoral Associate – Inflammatory Bowel Disease (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Immunology or Genetics (Research Center for Molecular Medicine of the Austrian Academy of Sciences)

Postdoctoral Associate – Epigenetics of Inflammatory Bowel Disease (Icahn School of Medicine at Mount Sinai)

Open Group Leader Position – Cancer Research (Oslo University Hospital)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

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