 | | Vol. 10.00 – 5 January, 2024 |
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| The authors showed that mitochondrial dysfunction in enterocytes inhibited chylomicron production and the transport of dietary lipids to peripheral organs.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that patient-derived intestinal organoids and tumouroids supplemented with immune cells could be used to study the on-target off-tumour toxicities of T cell-engaging bispecific antibodies.
[Nature Biomedical Engineering] |
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| Researchers showed that a tryptophan metabolite derived from Peptostreptococcus anaerobius, trans-3-indoleacrylic acid, facilitated colorectal carcinogenesis.
[Nature Cell Biology] |
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| The authors reported an in vivo murine model of colorectal cancer featuring deletion of wild-type Kras in the context of oncogenic Kras. Deletion of wild-type Kras exacerbates oncogenic KRAS signaling through MAPK and thus drives tumor initiation.
[Nature Communications] |
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| Scientists reported that regulating the IL12-p40/MHC class II signaling pathway was a critical mechanism by which p53 protected against radiation-induced gastrointestinal syndrome.
[Nature Communications] |
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| Knockout or inhibition of pirin dramatically increased FAS expression, FAS-dependent apoptosis, and attenuated colorectal tumor formation in mice.
[Advanced Science] |
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| Oral dosing of highly selective salt-inducible kinases (SIK) 1/2 compounds ameliorated disease in a murine colitis model.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers used a mouse intestinal organoid combined with cell model to explore the differences in metabolites and toxicity mechanisms induced by exposure to three nanoplastics.
[Science Of The Total Environment] |
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| To determine whether dextran sodium sulfate (DSS) treatment induced pathogenic changes in the microbiota, the authors investigated the microbiota-modulating effects of dextran sodium sulfate on murine microbiota in vitro.
[Gut Microbes] |
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| Real-time quantitative PCR was used to analyze the expression of miR-373 in human colorectal cancer cell lines and normal human colonic epithelial cells. Further validation of the differential expression of miR-373 in colorectal cancer cell lines was performed.
[Scientific Reports] |
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| The authors conduct a systematic search of the literature, and provide a thorough and in-depth analysis of the findings from randomised clinical trials trials, highlighting the advantages and disadvantages of neoadjuvant chemotherapy for early-stage colon cancer.
[Cancer Treatment Reviews] |
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| 232 exceptional health and medical research projects will share in $268 million through the National Health and Medical Research Council (NHMRC) Ideas Grant scheme announced today by the Minister for Health and Aged Care, the Hon Mark Butler MP.
[Cancer Stem Cell News, Intestinal Cell News, Mammary Cell News, Dermal Cell News] |
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| Owkin announced that it has entered into a collaboration agreement with MSD, the tradename of Merck & Co Inc., Rahway NJ USA to develop and commercialize AI-powered digital pathology diagnostics for the European Union market.
[Owkin] |
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| February 11 – 16, 2024
Galveston, Texas, United States |
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| | University of California San Francisco – San Francisco, California, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Human Technopole – Milan, Italy |
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| | MD Anderson Cancer Center – Houston, Texas, United States |
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| | Charité – Universitätsmedizin Berlin – Berlin, Germany |
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