Intestinal Cell News Volume 10.01 | Jan 12 2024

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    2024-01-12 | ICN 10.02


    Intestinal Cell News by STEMCELL Technologies
    Vol. 10.01 – 12 January, 2024
    TOP STORY

    Precancerous Nature of Intestinal Metaplasia with Increased Chance of Conversion and Accelerated DNA Methylation

    Researchers explored the precancerous nature of intestinal metaplasia (IM) by analysing epigenetic alterations. Genome-wide DNA methylation analysis was conducted by EPIC BeadArray using IM crypts isolated by Alcian blue staining.
    [Gut]

    Abstract
    PUBLICATIONSRanked by the impact factor of the journal

    CCR5 and CCL5 Gene Expression in Colorectal Cancer: Comprehensive Profiling and Clinical Value

    Researchers characterized the molecular features associated with CCR5/CCL5 expression in colorectal cancer and to determine whether CCR5/CCL5 levels could impact treatment outcomes.
    [Journal for Immunotherapy of Cancer]

    Full Article

    Targeted Modulation of Intestinal Epithelial Regeneration and Immune Response in Ulcerative Colitis Using Dual-Targeting Bilirubin Nanoparticles

    Investigators developed a colon dual-targeting nanoparticle, for orally delivering bilirubin through hydrogel encapsulation of hyaluronic acid-modified poly (lactic-co-glycolic acid) nanoparticles.
    [Theranostics]

    Full Article

    Death Receptor 5 Is Required for Intestinal Stem Cell Activity during Intestinal Epithelial Renewal at Homoeostasis

    The authors found that death receptor 5 gene deletion mice had impaired epithelial absorption and barrier function, resulting in delayed weight gain, which might be related to the general reduction of differentiated epithelial cells.
    [Cell Death & Disease]

    Full Article

    NELF and PAF1C Complexes Are Core Transcriptional Machineries Controlling Colon Cancer Stemness

    Scientists found that inducible inhibition of β-catenin suppressed elongation of Pol II and RNA polymerase-associated factor 1 complex (PAF1C) around the transcription start site (TSS) of LGR5.
    [Oncogene]

    Full ArticleGraphical Abstract

    Prognostic Impact and Immunotherapeutic Implications of NETosis-Related Gene Signature in Gastric Cancer Patients

    The authors explored the biological enrichment difference between high- and low-risk patients and found that many carcinogenic pathways were upregulated in the high-risk patients.
    [Journal Of Cellular And Molecular Medicine]

    Full Article

    Apigenin Exerts Anti-Cancer Effects in Colon Cancer by Targeting HSP90AA1

    Researchers characterized the molecular features associated with CCR5/CCL5 expression in colorectal cancer, and to determine whether CCR5/CCL5 levels could impact treatment outcomes.
    [Journal for Immunotherapy of Cancer]

    Full Article
    Organoids: Experts Talk Standardization at Nature Research Round Table
    REVIEWS

    FOXO3: At the Crossroads of Metabolic, Inflammatory, and Tumorigenic Remodeling in the Colon

    Diminished FOXO3 activity is associated with human diseases such as obesity, metabolic diseases, inflammatory diseases, and cancer.
    [American Journal Of Physiology-Gastrointestinal And Liver Physiology]

    Abstract

    Effect of GVHD on the Gut and Intestinal Microflora

    Gastrointestinal-Graft-versus-host disease causes intestinal immune system disorders, damages intestinal epithelial tissue such as intestinal epithelial cells, goblet, Paneth, and intestinal stem cells, and disrupts the intestinal epithelium’s physical and chemical mucosal barriers.
    [Transplant Immunology]

    Full Article
    INDUSTRY AND POLICY NEWS

    UCLA Cancer Center Wins Grants

    It was announced that researchers at UCLA Health Jonsson Comprehensive Cancer Center received two grants totaling $9.1 million from the National Cancer Institute to advance liquid biopsy technologies for the early detection of cancer.
    [Los Angeles Business Journal]

    Press Release
    FEATURED EVENT

    Tandem Meetings Transplantation & Cellular Therapy Meetings of ASTCT® and CIBMTR®

    February 21 – 24, 2024
    San Antonio, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Liver and Gastrointestinal Diseases

    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    Postdoctoral Fellow – Intestinal Stem Cells and Cancer

    The Francis Crick Institute – London, England, United Kingdom

    Research Associate – Liver Cell Isolation, Analysis & Immunology

    University of California San Francisco – San Francisco, California, United States

    Postdoctoral Researcher – Computational Cancer Evolution

    Human Technopole – Milan, Italy

    Assistant Data Scientist – Epigenetics & Molecular Carcinogenesis

    MD Anderson Cancer Center – Houston, Texas, United States

    > See All Jobs

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