 | | Vol. 10.02 – 19 January, 2024 |
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| Investigators treated 25 patients, 20 pancreatic and five colorectal, who were positive for minimal residual mKRAS disease after locoregional treatment in a Phase I study of fixed-dose Amph-Peptides-2P and ascending-dose Amph-CpG-7909.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists overlapped differentially expressed genes with publicly available microarray datasets and performed functional in vitro studies, including an in vitro suppression assay and organoid systems, to model gene expression changes observed in Crohn’s disease Tregs and to test predicted therapeutics.
[Gastroenterology] |
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| Mice supplemented with P. goldsteiniior its bile acid metabolite, 7-keto-lithocholic acid (7-keto-LCA), showed reduced aspirin-mediated damage of the intestinal niche and gut barrier, effects that were lost with a P. goldsteinii hdhA mutant unable to generate 7-keto-LCA.
[Cell Host & Microbe] |
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| In addition to mapping the intratumoral heterogeneity of consensus molecular subtypes and their microenvironment, researchers identified cell communication events in the tumor-stroma interface of consensus molecular subtype 2 carcinomas.
[NPJ Precision Oncology] |
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| The mitochondrial DNA copy number was detected by qRT-PCR in 532 patients, and the expression of CD3 and CD8 in 485 patients was detected by immunohistochemistry.
[British Journal Of Cancer] |
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| Researchers investigated the effects of the two ANO1-inhibitors niclosamide and benzbromarone in vitro and in vivo in mouse models for cystic fibrosis and asthma.
[Scientific Reports] |
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| Glucose uptake and lactate production assays were used to evaluate the importance of B7H3 expression in gastric cancer mesenchymal stem cells-treated gastric cancer cells. The therapeutic efficacy of oxaliplatin and paclitaxel was determined using CCK-8 and colony formation assays.
[Journal Of Cellular Biochemistry] |
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| Scientists investigated the antiproliferative and antitelomerase effects of silymarin on four human colorectal cancer and HepG2 hepatocellular carcinoma cell lines. The cell viability and telomerase activity were assessed using MTT and the TRAP assay, respectively.
[Planta Medica] |
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| The authors summarize the latest published research on resveratrol’s effect in the prevention of colorectal cancer, its regulatory actions, specifically on the p53 pathway, and its treatment options.
[Journal Of Advanced Research] |
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| Scientists highlight the progress and impact of the hydrogel-based drug delivery system in IBD treatment through regulation of physical barrier immune responses, promotion of mucosal repair, and improvement of gut microbiota.
[Biomaterials Science] |
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| Poor-quality studies are polluting the literature — a group will study the businesses that produce them to stem the flow of bogus research.
[Nature News] |
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| February 14 – 16, 2024
Hinxton, England, United Kingdom |
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| | Columbia University Irving Medical Center – New York, New York, United States |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | Human Technopole – Milan, Italy |
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