 | | Vol. 10.03 – 26 January, 2024 |
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| Investigators demonstrated that inflammation-induced epithelial abnormalities compromised farnesoid X receptor signaling and altered bile acid’s profile in a mouse colitis-associated colorectal cancer model.
[JCI Insight] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors explored the alleviating effects and mechanisms of exopolysaccharides produced by Limosilactobacillus mucosae CCFM1273 on ulcerative colitis.
[International Journal Of Biological Macromolecules] |
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| An in vivo mouse model was built to investigate the protective and reparative effects of different concentrations of wheat peptides on non-steroidal anti-inflammatory drugs-induced intestinal injury.
[Food & Function] |
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| Researchers evaluated the effect of SMAD7 variants on the risk of CRC in the Chinese Han population. A total of five single nucleotide polymorphisms in SMAD7 were genotyped among 696 CRC patients and 696 healthy participants using the MassARRAY iPLEX platform.
[Cell Cycle] |
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| Scientists used the SV40 large T antigen gene to generate an immortalized cell line. Single-cell screening technology was used to sort positive cell clusters with epithelial characteristics for passage.
[Parasites & Vectors] |
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| Intestinal samples were obtained from 126–127 and 140–141 days gestation sheep. Samples were quantified per crypt in at least 100 crypts per animal and confirmed as Paneth cells through in immunohistochemistry.
[Frontiers In Veterinary Science] |
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| Researchers explored the role of RNF183 on colon cancer (COAD). They found that RNF183 promoted COAD stemness by affecting fatty acid oxidation.
[Nutrition And Cancer-An International Journal] |
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| In order to evaluate the effects of zinc oxide nanoparticles on colon and prostate cell lines, oxidative stress factors ROS, MDA, and GSH and mitochondrial function were evaluated.
[Toxicology Research] |
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| Intestinal homeostasis is achieved by the balance among intestinal epithelium, immune cells, and gut microbiota. Gasdermins, a family of membrane pore forming proteins, can trigger rapid inflammatory cell death in the gut, mainly pyroptosis and NETosis.
[Seminars In Immunology] |
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| Researchers review recent findings that indicate Wnt is a regulator of many other cellular physiological activities, such as macropinocytosis, endosome trafficking, protein stability, focal adhesions, and lysosomal activity.
[IUBMB Life] |
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| InnoCare Pharma, a leading biopharmaceutical company focusing on the treatment of cancer and autoimmune diseases, announced that the first pediatric patient has been dosed in clinical trial with its second generation pan-TRK inhibitor zurletrectinib at Sun Yat-sen University Cancer Center.
[InnoCare Pharma] |
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| STFX Interdisciplinary Health professor Dr. Arlinda Ruco received a Canadian Cancer Society Emerging Scholar Research Grant valued at over $594,000.
[989 XFM] |
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| March 11 – 13, 2024
Lisbon, Portugal |
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| | Imperial College London – London, England, United Kingdom |
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| | Columbia University Irving Medical Center – New York, New York, United States |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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