 | | Vol. 10.04 – 2 February, 2024 |
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| Through hepatectomy and transcriptomic and proteomic profiling, scientists identified pigment epithelium-derived factor (PEDF), a liver-derived soluble Wnt inhibitor, which restrained intestinal stem cell hyperproliferation to maintain gut homeostasis by suppressing the Wnt/β-catenin signaling pathway.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers established a human intestinal stem cell (ISC) culture method expanded under feeder-free and fully defined conditions through selective enrichment of ISC populations within human intestinal organoid derived from human indcuedpluripotent stem cells.
[Nature Communications] |
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| The authors described non-professional efferocytosis of Salmonella-infected enterocytes by neighboring epithelial cells in the neonatal intestine.
[Journal Of Experimental Medicine] |
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| Scientists demonstrated that oxaliplatin induced RB1 phosphorylation, which was associated with the resistance to neoadjuvant oxaliplatin-based chemotherapy in locally advanced rectal cancer.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators explored the causal relationship between oxidative stress, somatic mutations in pre-tumor-initiated normal tissues, and tumor incidence in the small intestines of MUTYH-proficient and MUTYH-deficient mice.
[Genome Research] |
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| The authors elucidated the process by which L. paracasei VL8 and its synbiotc combination with mannan-oligosaccharide repair the intestinal barrier function in dextran sodium sulfate-induced colitis mice.
[Journal Of Agricultural And Food Chemistry] |
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| Researchers compared the impact of two different types of diets, a crude diet and an AIN-93G-formula purified diet, on epithelial integrity and the gut microbiota.
[International Immunology] |
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| Investigators characterized the profile of prostanoids and their synthesis enzyme expression in a murine model of postoperative ileus (POI) and to determine whether the altered prostanoids could contribute to POI.
[Journal Of Surgical Research] |
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| The authors provide a critical overview on the state-of-the-art on existing 3D models of intestinal inflammation and discusses the remaining challenges, providing insights on possible pathways towards achieving IBD mimetic models.
[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] |
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| Given the critical role of the intestinal mucosal system in health and disease, the protective effects of dietary polysaccharides may be potentially valuable for the prevention and treatment of gut-related diseases.
[Food & Function] |
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| The Icahn School of Medicine at Mount Sinai has been awarded a grant of more than $4 million from The Leona M. and Harry B. Helmsley Charitable Trust to support an innovative research project aimed at understanding the early stages of Crohn’s disease before noticeable symptoms develop.
[Mount Sinai] |
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| March 18 – 19, 2024
London, England, United Kingdom |
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| | University of Washington – Seattle, Washington, United States |
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| | University of Virginia – Charlottesville, Virginia, United States |
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| | Imperial College London – London, England, United Kingdom |
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| | Columbia University Irving Medical Center – New York, New York, United States |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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