 | | Vol. 10.05 – 9 February, 2024 |
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| Scientists established a colorectal cancer-derived organoid biobank and induced acquired drug resistance by repeated low-level exposures of chemo-agents.
[Nature Cancer] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers tested the hypothesis that cationic lipid nanoparticle delivery of interferon β (IFNβ)-encoding plasmid to tumors was effective in restoring IFNβ expression to suppress tumor immune evasion.
[ACS Nano] |
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| While considering age, sex, and proximal–distal variations, investigators used a multi-omics approach in non-human primates to shed light on the heterogeneity of intestinal aging and identify potential regulators of gut aging.
[Nature Aging] |
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| Researchers presented an in vitro model specifically designed to examine the effects of systemic lupus erythematosus (SLE) on epithelial cells. They utilized human colon organoids that were stimulated with serum from SLE patients.
[EMBO Molecular Medicine] |
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| Researchers employed organoids derived from rectal cancer and single-cell whole-genome sequencing to investigate the long-term evolution of subclones in response to radiation.
[Cell Reports] |
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| Researchers revealed that follistatin-like 3 (FSTL3) was overexpressed in malignant cells in the colorectal cancer microenvironment, notably, the expression level of FSTL3 was related to tumor immune evasion and the clinical efficacy of anti-PD1 therapy.
[Cell Death & Disease] |
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| The authors investigated the effect of an activating GNAS mutation in colorectal cancer cell lines on gene expression and cell proliferation in vitro, and tumor growth in vivo. GNAS-mutated HCT116 cells showed stimulated synthesis of cAMP as compared to parental cells.
[International Journal of Cancer] |
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| Scientists synthesized a nitroaromatic nannocystin through improved preparation of a key fragment, and characterized its in vitro activity and in vivo efficacy against colorectal cancer.
[Acta Pharmacologica Sinica] |
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| Investigators demonstrated that phosphoglycerate dehydrogenase (PHGDH) expression was significantly up-regulated in colorectal cancer (CRC). PHGDH expression was positively correlated with that of the aryl hydrocarbon receptor and its target genes, CYP1A1 and CYP1B1, in CRC cells.
[FEBS Journal] |
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| Trophoblast cell surface antigen 2 (TROP2) expression strongly correlated with promoter methylation in different colorectal tumor cell lines.
[Scientific Reports] |
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| The authors investigated the anticancer effects of membrane vesicles from Lentilactobacillus buchneri strain HBUM07105 probiotic isolated from conventional and unprocessed yogurt in Arak province, Iran, against gastric and colon cancer cell lines.
[Scientific Reports] |
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| Enzalutamide loaded poly lactic-co-glycolic acid nanoparticles coated with polysarcosine and d-α-Tocopheryl polyethylene glycol 1000 succinate were prepared using a three-step modified nanoprecipitation method combined with self-assembly.
[Heliyon] |
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| The relationship between miR-7 and toll-like receptor 4 (TLR4) was analyzed through dual luciferase reporter assays. MTT, wound healing, and cell invasion assays were conducted to examine the effects of TLR4 and miR-7 on CRC cell proliferation, migration, and invasion.
[Functional & Integrative Genomics] |
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| Scientists discuss recent insights on clusterin (CLU) in colorectal cancer and its roles in enhancing the plasticity of cells and further consider the implications of CLU as a prospective target for therapeutic intervention.
[Cancer and Metastasis Reviews] |
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| With a new $2 million federal grant, a researcher with the Case Western Reserve University School of Medicine will lead a team to further explore preliminary findings of an effective treatment for colorectal and possibly other cancers.
[Case Western Reserve University (EurekAlert)] |
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| Monash Biomedicine Discovery Institute researcher Dr Lochlan Fennell has been awarded $100,000 over 12 months by Cure Cancer to investigate the possibility of restoring the youthfulness of the cells that cause bowel cancer.
[Monah University] |
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| February 27 – 29, 2024
London, England, United Kingdom |
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| | Ume̴ University РUme̴, Sweden |
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| | University of Virginia – Charlottesville, Virginia, United States |
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| | Imperial College London – London, England, United Kingdom |
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| | Columbia University Irving Medical Center – New York, New York, United States |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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