 | | Vol. 10.06. – 16 February, 2024 |
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| Investigators reported that corticosteroids directly targeted intestinal epithelium, potentially worsening immune-mediated gastrointestinal damage. Corticosteroids administered to mice in vivo and intestinal organoid cultures ex vivo reduced epithelial proliferation.
[Journal Of Clinical Investigation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using mouse colon organoids, researchers discovered that proximal and distal colon stem cells had distinct transcriptional programs that regulated stemness and differentiation.
[Nature Communications] |
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| Scientists reported that EF-hand domain-containing protein D2 (EFHD2), highly expressed in normal intestine tissues but decreased in intestinal biopsy samples of ulcerative colitis patients, protected intestinal epithelium from TNF-induced intestinal epithelial cell apoptosis.
[Nature Communications] |
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| Investigators screened for ubiquitin-specific proteases that interacted with yin yang 1 (YY1), and identified ovarian tumor protease family member (OTUD3) as a deubiquitinase for YY1.
[Cell Death & Disease] |
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| Investigators identified transmembrane protein 65 (TMEM65) amplification by genomic hybridization microarray to profile copy-number variations in gastric cancer.
[Oncogene] |
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| Leucine-rich repeat-containing 8A (LRRC8A) proteins were found highly expressed in hematogenous metastasis from human colorectal cancer samples.
[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] |
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| miR-1825 was highly expressed in colorectal cancer tissues, which was positively correlated with lymph node metastasis and distant metastasis.
[iScience] |
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| In a human enteroid model, scientists reported that the zoonotic clonal complex 1 (CC1) genotype had a 40% higher translocation frequency than the non-zoonotic CC16 genotype.
[iScience] |
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| Researchers investigated the regulation of forkhead box A1 (FOXA1) expression in colorectal cancer (CRC), focusing on well-differentiated CRC cells, where FOXA1 was robustly expressed.
[Molecular And Cellular Biology] |
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| The authors reported that cold atmospheric plasma treatment induced comparable effects on apoptosis, reactive oxygen species and reactive nitrogen species, as well as the expression of apoptosis-related proteins in both microsatellite instability and microsatellite stability cells.
[Scientific Reports] |
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| A nano-catalyst based on calcium peroxide and the chemotherapeutic drug doxorubicin hydrochloride co-loaded into hollow Prussian blue nanoparticles was developed to achieve synergistic cancer treatment through chemodynamic/chemo/photothermal mechanisms.
[Scientific Reports] |
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| Knockdown and overexpression olfactomedin 2 (OLFM2) cell lines were constructed using small interfering RNA and overexpression plasmids to explore the role of OLFM2 in the migration and invasion of colorectal cancer through transwell, and wound healing experiments.
[BMC Cancer] |
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| The authors review the execution of intestinal epithelial metabolism in health and illustrate how perturbation of epithelial metabolism affects experimental gut inflammation and tumorigenesis.
[Trends In Cell Biology] |
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| Scientists systematize the available data regarding the effects of apigenin on gastric cancer cells, in terms of cell proliferation, apoptosis, Helicobacter pylori infection, and molecular targets.
[Biomedicine & Pharmacotherapy] |
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| The authors highlight critical aspects of intestinal organoids in IBD, such as their potential applications, viability, cell renewal ability, and barrier functionality.
[Inflammation Research] |
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| MiNK Therapeutics announced the first patient dosed in a Phase II investigator sponsored study for agenT-797 in second line gastroesophageal cancer, led by Dr. Yelena Janjigian at Memorial Sloan Kettering Cancer Center.
[MiNK Therapeutics] |
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| Takeda Canada, Inc. announced its support of the Canadian Inflammatory Bowel Disease Research Consortium’s (CIRC) one million PIONEER Grant in its second year.
[Takeda] |
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| March 3 – 8, 2023
Ventura, California, United States |
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| | City of Hope – Monrovia, California, United States |
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| | UC Davis – Davis, California, United States |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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| | Ume̴ University РUme̴, Sweden |
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