 | | Vol. 10.07 – 23 February, 2024 |
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| Scientists identified a novel compound, columbamine, which triggered LC3-associated phagocytosis and enhanced efferocytosis in an animal model of colitis to attenuate inflammation.
[Autophagy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors observed a global aberrant lysine lactylation abundance profile in colorectal cancer that negatively correlated with prognosis.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Using super-resolution microscopy on human intestinal biopsies and Caco-2 cells, researchers reported that two distinct multiprotein belts were basal of the tight junctions as the intestinal epithelia mature.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators uncovered that replicative senescent colorectal cancer cells exhibited increased levels of mRNA N6-methyladenosine and methyltransferase METTL3.
[Oncogene] |
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| Researchers discovered a stable cytoplasmic circular RNA named circUSP1 in gastric cancer (GC). CircUSP1 upregulation in GC tissues correlated with tumor size and differentiation.
[Oncogene] |
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| Scientists reported that intestinal epithelium-specific BECLIN1 deletion in adult mice led to rapid fatal enteritis with compromised gut barrier integrity, highlighting its intrinsic critical role in gut maintenance.
[Communications Biology] |
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| The authors generated human colorectal cancer (CRC) organoids with naturally selected genetic mutation profiles and exposed them to two different conditions by modulating the extracellular matrix.
[iScience] |
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| Scientists identified the key molecules responsible for B. subtilis-induced antimicrobial peptides and their molecular mechanisms in a human intestinal epithelial cell line.
[Probiotics And Antimicrobial Proteins] |
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| Investigators identified SLC22A18 variants found in multiple populations by searching public databases and determined the in vitro effects of these missense variations on transporter expression and cancer progression.
[Scientific Reports] |
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| The authors summarize the latest advances in research on the sources and extraction methods, applications, and mechanisms in IBD and colitis-associated cancer therapy, overcoming drug resistance, safety, stability, and clinical application of plant-derived vesicle-like nanoparticles.
[Molecular Therapy] |
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| Pfizer, Inc. announced that the European Commission has granted marketing authorization for VELSIPITY® to treat patients 16 years of age and older with ulcerative colitis who have had an inadequate response, lost response, or were intolerant to either conventional therapy, or a biological agent.
[Pfizer] |
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| Mainz Biomed announced a distribution partnership with Praxisdienst, which marked an important step in Mainz Biomed’s mission to enhance healthcare delivery across Germany, focusing on the accessibility of their flagship product, ColoAlert®
[Mainz Biomed] |
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| March 24 – 29, 2024
Galveston, Texas, United States |
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| | University of Basel – Basel, Switzerland |
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| | City of Hope – Monrovia, California, United States |
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| | UC Davis – Davis, California, United States |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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