 | | Vol. 10.08 – 1 March, 2024 |
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| Researchers identified that F. nucleatum was enriched preferentially in KRAS p.G12D mutant colorectal cancer tumor tissues and contributed to colorectal tumorigenesis in Villin-Cre/KrasG12D+/- mice.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators discovered that exosome-derived disintegrin and metalloproteinase 17 (ADAM17) derived from the circulating exosomes of patients with colorectal cancer could serve as a blood-based biomarker for predicting metastasis.
[Journal of Experimental & Clinical Cancer Research] |
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| Scientists established a panel of colorectal cancer patient-derived organoids (PDOs) as clinically relevant biological systems, of which three pairs of matched metastatic malignant PDOs were derived from the primary sites and metastatic lesions.
[NPJ Precision Oncology] |
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| The authors reported that the protein arginine methyltransferase 1 (PRMT1) promoted glycolysis, proliferation, and tumorigenesis in colorectal cancer cells.
[Cell Death & Disease] |
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| Scientists investigated the Runt-related transcription factor 1 (RUNX1) mediated crosstalk between tumor cells and M2 polarized tumor associated macrophages in colorectal cancer, as well as its relationship with neoplastic angiogenesis.
[Biomarker Research] |
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| Researchers reported that long-term culturing of colonic epithelial organoids generated from stem cells of healthy and diseased individuals resulted in decreased nucleotide element 1 (LINE-1) methylation level, when compared to tissue of origin and short-term cultures.
[Scientific Reports] |
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| Pyrroline-5-carboxylate reductase 1 (PYCR1) expression was manipulated by depletion or overexpression approaches in gastric cancer cells, and these cells were applied to explore the functional roles of PYCR1.
[Heliyon] |
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| The authors explore the communication function and mechanism of exosomes derived from different cells in cancer metastasis, while also presenting an outlook on current research advancements and future application prospects.
[iScience] |
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| Gritstone Oncology, Inc. has been granted Fast Track designation by the US FDA for its personalized immunotherapy, Granite-001.
[Gritstone Oncology, Inc. (BNN Breaking)] |
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| The Colorectal Cancer Alliance Project Cure initiative was excited to open its request for proposals. Tens of millions of dollars will be available to researchers from around the world whose work aims to expedite colorectal cancer research to a curable science.
[Colorectal Cancer Alliance] |
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| Cardiff Oncology, Inc. announced that the first patient was dosed in its randomized first-line Phase II trial, for patients with RAS-mutated metastatic colorectal cancer.
[Cardiff Oncology] |
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| BeiGene, Ltd. announced that the US FDA has accepted a Biologics License Application for TEVIMBRA® , in combination with fluoropyrimidine- and platinum-containing chemotherapy, for the treatment of patients with locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma.
[BeiGene] |
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| April 4 – 5, 2024
Cincinnati, Ohio, United States |
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| | The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| | University of Groningen – Groningen, Netherlands |
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| | Augusta University – Augusta, Georgia, United States |
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| | University of Basel – Basel, Switzerland |
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| | City of Hope – Monrovia, California, United States |
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