 | | Vol. 10.10 – 22 March, 2024 |
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| Investigators used CRISPR base editors to introduce different F-box and WD repeat domain-containing 7 (FBXW7) hotspot mutations in human colon organoids.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported pH-related phenotypes of 68 colorectal cancer cell lines by measuring i) extracellular acidification as a readout of acid production by fermentative metabolism and ii) growth of cell biomass over a range of extracellular pH levels as a measure of the acid sensitivity of proliferation.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers discovered that Alu RNA induced epithelial-to-mesenchymal transition through nucleotide-binding domain leucine-rich repeat containing 3 inflammasome activation and IL-1β release in colorectal cancer cells.
[Experimental & Molecular Medicine] |
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| The authors investigated how mitochondrial sirtuin 4 (SIRT4) affected intestinal homeostasis. Intestinal SIRT4 loss promoted cell proliferation in the intestine following ionizing radiation.
[Cell Reports] |
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| Investigators uncovered the involvement of an upregulated E3 ubiquitin ligase called RNF166, which destabilized angiomotins, activated yes-associated protein, and was associated with a poor prognosis in colorectal cancer patients.
[Cell Death & Disease] |
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| Scientists identified a novel casein kinase II-dependent mechanism for SALL2 regulation and provided new insights into the interplay between these two proteins and their role in cell survival and proliferation.
[Cell Death & Disease] |
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| Using a dextran sulfate sodium salt (DSS)-induced colitis mouse model, researchers investigated the reparative effects of notoginsenoside R1 on mucosal barrier damage after the acute injury stage of DSS exposure.
[Acta Pharmacologica Sinica] |
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| Scientists highlight the biological rationale and explore the clinical activity of therapies that target claudin 18.2 in patients with advanced-stage gastric cancer and explore the potential for expansion of claudin 18.2-targeted therapies to patients with other claudin 18.2-positive solid tumours.
[Nature Reviews Clinical Oncology] |
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| The authors provide a comprehensive overview of the dual roles played by the ubiquitin‒proteasome system and autolysosome system in colorectal cancer, elucidating their impact on the initiation and progression of this disease while also highlighting their compensatory relationship.
[Cell Death Discovery] |
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| Natera, Inc. announced a collaboration with the Fédération Francophone de Cancérologie Digestive and CHU Dijon Bourgogne on a prospective Phase III clinical trial in France investigating molecular residual disease guided adjuvant treatment in stage II colorectal cancer patients.
[Natera, Inc.] |
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| | University of Kentucky – Lexington, Kentucky, United States |
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| | University of Montpellier – Montpellier, France |
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| | The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| | University of Groningen – Groningen, Netherlands |
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| | City of Hope – Monrovia, California, United States |
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