Intestinal Cell News Volume 10.11 | April 5 2024

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    2024-04-05 | ICN 10.11


    Intestinal Cell News by STEMCELL Technologies
    Vol. 10.11 – 5 April, 2024
    TOP STORY

    Mex-3 RNA Binding Family Member a (MEX3A)/circMPP6 Complex Promotes Colorectal Cancer Progression by Inhibiting Autophagy

    Researchers identified that MEX3A, frequently upregulated in colorectal cancer tissues, predicted poorer patient survival.
    [Signal Transduction And Targeted Therapy]

    Full Article
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    Accelerated Intestinal Wound Healing via Dual Electrostimulation from a Soft and Biodegradable Electronic Bandage

    Investigators reported a self-powered electronic bandage made from soft and biodegradable materials that could accelerate wound healing in the intestine.
    [Nature Electronics]

    Abstract

    Select EZH2 Inhibitors Enhance Viral Mimicry Effects of DNMT Inhibition through a Mechanism Involving NFAT:AP-1 Signaling

    Researchers reported that colorectal cancer cells that were insensitive to single-agent enhancer of zeste homolog 2 (EZH2) inhibition became sensitive as compensatory lysine-27 trimethylation on histone H3 mediated silencing emerged upon DNA methyltransferase inhibitor treatment.
    [Science Advances]

    Full Article

    USP26 Promotes Colorectal Cancer Tumorigenesis by Restraining PRKN-Mediated Mitophagy

    Scientists evidenced the role of ubiquitin-specific peptidase 26 (USP26) in promoting colorectal cancer tumorigenesis in a parkin RBR E3 ubiquitin-protein ligase (PRKN) protein-dependent manner.
    [Oncogene]

    Abstract

    LncRNA WFDC21P Interacts with SEC63 to Promote Gastric Cancer Malignant Behaviors by Regulating Calcium Homeostasis Signaling Pathway

    The authors investigated the biological effects of lncRNA WAP four-disulfide core domain 21 pseudogene (WFDC21P) in gastric cancer, and reported that WFDC21P downregulation resulted in suppressed proliferation, tumorigenesis, migration, invasion, and promoted apoptosis.
    [Cancer Cell International]

    Full Article

    Synthesis and Biological Evaluation of Echinomycin Analogs as Potential Colon Cancer Agent

    Analogs of echinomycin, a cyclic peptide natural product with potent toxicity to several human cancer cell lines, were synthesized, and their biological activities against human colon cancer cells were investigated.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Clinical Challenges of Consensus Molecular Subtype CMS4 Colon Cancer in the Era of Precision Medicine

    Scientists provide insights into the clinico-biological characteristics of the consensus molecular subtype (CMS) CMS4 colorectal cancer subgroup, the molecular pathways driving this subtype, and available diagnostic options.
    [Clinical Cancer Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    Bausch Health, Canada Inc. Announces First Public Drug Plan Listings for PrUCERIS® (Budesonide) Aerosol Foam To Help Address the Unmet Need for the Treatment of Mild to Moderate Distal Ulcerative Colitis in Adults

    Bausch Health Canada, Inc. announced the first public drug plan listings for PrUCERIS® (budesonide) aerosol foam to treat mild to moderate distal ulcerative colitis in adults.
    [Bausch Health Canada, Inc.]

    Press Release

    Varley Awarded Research Grant From the American Cancer Society and UW Carbone Cancer Center

    Dr. Patrick Varley was awarded a one-year, $60,000 Institutional Research Grant that provides funding for a pilot study evaluating the effect of residential neighborhood disparities on colorectal cancer outcomes within the Veterans Health Administration system.
    [University of Wisconsin-Madison]

    Press Release
    FEATURED EVENT

    12th Annual Symposium on Global Cancer Research

    May 6-9, 2024
    Online

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    JOB OPPORTUNITIES

    Postdoctoral Associate – Gastroenterology

    Duke University School of Medicine – Durham, North Carolina, United States

    Research Technician – Molecular Virology and Organoids

    Baylor College of Medicine – Houston, Texas, United States

    Associate Professor – Gastroenterology Issues

    University of Colorado – Aurora, Colorado, United States

    Postdoctoral Scholar – Molecular Biology Research

    University of Kentucky – Lexington, Kentucky, United States

    PhD Student – Intestinal Tumorigenesis

    University of Montpellier – Montpellier, France

    > See All Jobs

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