Intestinal Cell News Volume 10.14 | Apr 26 2024

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    Jamie Kang
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    2024-04-26 | ICN 10.14


    Intestinal Cell News by STEMCELL Technologies
    Vol. 10.14 – 26 April, 2024
    TOP STORY

    Inhibiting the cGAS-STING Pathway in Ulcerative Colitis with Programmable Micelles

    Programmable nanomicelles were designed for colitis treatment and loaded with RU.521, an inhibitor of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway.
    [ACS Nano]

    AbstractGraphical Abstract
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    LSD1 Drives Intestinal Epithelial Maturation and Controls Small Intestinal Immune Cell Composition Independent of Microbiota in a Murine Model

    Scientists showed that intestinal-epithelial intrinsic expression of lysine-specific demethylase 1A (LSD1) was necessary for the postnatal maturation of intestinal epithelium and maintenance of this developed state during adulthood.
    [Nature Communications]

    Full Article

    T-Bet Regulates Ion Channels and Transporters and Induces Apoptosis in Intestinal Epithelial Cells

    The findings unveiled a previously unrecognized role of T-bet in intestinal epithelial cells for inducing apoptosis, diarrhea, and local inflammation, thus implicating its potential as a therapeutic target for the treatment of cancer and inflammatory diseases.
    [Advanced Science]

    Full Article

    Sirt2 Inhibition Improves Gut Epithelial Barrier Integrity and Protects Mice from Colitis

    Researchers established that small-molecule inhibitors of Sirt2 were promising treatment strategies for inflammatory bowel disease. Small-molecule inhibitors of enzymes had been increasingly used to investigate the biological function of enzymes.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    CircSOD2: Disruption of Intestinal Mucosal Barrier Function in Ulcerative Colitis by Regulating the miR-378g/Snail1 Axis

    Lipopolysaccharide-induced Caco2 cells were used to mimic ulceratvie colitis cell models. CircSOD2, miR-378g, and Snail1 levels were determined by quantitative real-time PCR.
    [Journal Of Gastroenterology And Hepatology]

    Abstract

    Mulberry Leaf-Derived Morin Activates β-Catenin by Binding to Frizzled7 to Promote Intestinal Stem Cell Expansion Upon Heat-Stable Enterotoxin B Injury

    Investigators revealed an unexpected role of leaf-derived morin, which represents molecular signaling targeting the Frizzled7 (FZD7) platform instrumental for controlling intestinal stem cells regeneration upon stable enterotoxin b injury.
    [Journal Of Agricultural And Food Chemistry]

    AbstractGraphical Abstract
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    REVIEWS

    Recent Progress on Engineered Micro/Nanomaterials Mediated Modulation of Gut Microbiota for Treating Inflammatory Bowel Disease

    The authors present the interactions among the immune system, intestinal barrier, and gut microbiome. Recent advances in administration routes and methods that positively regulate intestinal flora for inflammatory bowel disease have been reviewed.
    [Journal Of Controlled Release]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Palisade Bio Successfully Demonstrates Bioactivation of PALI-2108 in Ex-Vivo Study of Normal Healthy and Ulcerative Colitis Patients’ Stool

    Palisade Bio, Inc. announced the successful completion of its analysis evaluating ex-vivo bioactivation of PALI-2108, an orally administered, locally acting colon-specific phosphodiesterase-4 (PDE4) inhibitor prodrug in development for patients affected by ulcerative colitis.
    [Palisade Bio, Inc.]

    Press Release
    FEATURED EVENT

    2024 Immunology Symposium

    May 17, 2024
    Madison, Wisconsin, United States

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    JOB OPPORTUNITIES

    PhD Position – Nanoparticles for Intestinal Diseases

    University of Groningen – Groningen, Netherlands

    Researcher – Permeability Biomarkers Intestinal, Liver, and Gastro-Intestinal Diseases

    Sapienza – Rome, Italy

    Postdoctoral Fellow – Host-Immune Cell Interactions

    Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States

    Postdoctoral Scientist – Cancer Research

    Cedars-Sinai Medical Center – Los Angeles, California, United States

    PhD Scholarship – Regulatory T Cell Therapy for Inflammatory Bowel Disease

    Monash University – Melbourne, Victoria, Australia

    > See All Jobs

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