INTESTINAL CANCERS & DISEASES Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation Researchers showed that cells of the antral stomach have a previously unappreciated propensity for conversion into functional insulin-secreting cells. Native antral endocrine cells shared a surprising degree of transcriptional similarity with pancreatic β cells, and expression of β cell reprogramming factors in vivo converted antral cells efficiently into insulin+ cells with close molecular and functional similarity to β cells. [Cell Stem Cell] Full Article | Graphical Abstract | Press Release Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development Investigators showed that Smyd3 expression in mice is required for chemically induced liver and colon cancer formation. In these organs Smyd3 functions in the nucleus, stimulating the transcription of several key regulators involved in cell proliferation, epithelial-mesenchymal transition, the JAK/Stat3 oncogenic pathway, as well as the Myc and Ctnnb1 oncogenes. [Cancer Cell] Abstract | Graphical Abstract Withaferin-A Suppress AKT Induced Tumor Growth in Colorectal Cancer Cells Researchers explored the anti-tumorigenic effects of withaferin A (WA) on colorectal cancer cells (CRC) overexpressing AKT in preclinical models. Their results indicated that WA, a natural compound, resulted in significant inhibition of AKT activity and led to the inhibition of cell proliferation, migration and invasion by downregulating the epithelial to mesenchymal transition markers in CRC cells overexpressing AKT. [Oncotarget] Full Article LncRNA H19 Regulates Intestinal Epithelial Barrier Function via miR-675 by Interacting with RNA-Binding Protein HuR Scientists report that H19 plays an important role in controlling the intestinal epithelial barrier function by serving as a precursor for microRNA miR-675. [Mol Cell Biol] Abstract Intestine-Specific Homeobox (ISX) Induces Intestinal Metaplasia and Cell Proliferation to Contribute to Gastric Carcinogenesis Researchers elucidated the role of ISX in the development of intestinal metaplasia (IM) and gastric carcinogenesis. The presence of IM and Helicobacter pylori infection in human stomach was correlated with ISX expression. ISX expression in gastric cancer and adjacent mucosa were correlated. [J Gastroenterol] Abstract Actin-Depolymerizing Factor and Cofilin-1 Have Unique and Overlapping Functions in Regulating Intestinal Epithelial Junctions and Mucosal Inflammation Investigators examined the roles of actin-depolymerizing factor and cofilin-1 in regulating the structure and functions of epithelial adherens and tight junctions in the intestinal epithelium. [Am J Pathol] Abstract INTESTINAL STEM CELL & ORGANOID RESEARCH BVES Regulates Intestinal Stem Cell Programs and Intestinal Crypt Viability after Radiation Researchers hypothesized that blood vessel epicardial substance (BVES) influences intestinal stem cell programs and is critical to small intestinal homeostasis after radiation injury. [Stem Cells] Abstract Cdk4 Functions in Multiple Cell Types to Control Drosophila Intestinal Stem Cell Proliferation and Differentiation The authors showed that genetic modulation of CyclinD/Cdk4 activity or mTOR-dependent signaling cell-autonomously regulates enterocyte growth, which influences intestinal stem cells proliferation and enteroblast differentiation. [Biol Open] Full Article Wnt Signaling Inhibition Deprives Small Intestinal Stem Cells of Clonogenic Capacity Investigators revealed the functional consequences of inhibition of canonical Wnt signaling in the intestinal epithelium. Suppression of Wnt/β-catenin signaling affected asymmetric division of intestinal stem cells rather than proliferation. [Genesis] Abstract | Full Article |