Intestinal Cell News Volume 2.07 | Feb 26 2016

Tumor Suppressive Role of Sestrin2 during Colitis and Colon Carcinogenesis
Investigators showed that human SESN2 expression is elevated in the colon of ulcerative colitis patients but is lost upon p53 inactivation during colon carcinogenesis. [eLife] Full Article | Download Full Article

Novel Role of STRAP in Progression and Metastasis of Colorectal Cancer through Wnt/β-Catenin Signaling
Researchers showed the molecular mechanism by which Serine-Threonine Kinase Receptor-Associated Protein (STRAP) induces colorectal cancer metastasis by promoting β-catenin signaling through its stabilization. [Oncotarget] Full Article

Long Non-Coding RNA MALAT1 Increases AKAP-9 Expression by Promoting SRPK1-Catalyzed SRSF1 Phosphorylation in Colorectal Cancer Cells
Researchers investigated the molecular mechanism by which MALAT1 enhances AKAP9 expression in colorectal cancer SW480 cells. They found that MALAT1 interacts with both SRPK1 and SRSF1. [Oncotarget] Full Article

The miR-27a-Calreticulin Axis Affects Drug-Induced Immunogenic Cell Death in Human Colorectal Cancer Cells
The authors sought to verify whether miR-27a is implicated in immunogenic cell death, having demonstrated that it directly targets calreticulin. [Cell Death Dis] Full Article

The Activation of ERK1/2 and JNK MAPK Signaling by Insulin/IGF-1 Is Responsible for the Development of Colon Cancer with Type 2 Diabetes Mellitus
The authors investigated the effects and mechanisms of insulin and insulin-like growth factor 1 (IGF-1) in colon cancer development in vitro and in vivo. Insulin and IGF-1 alone or together elevated proliferation and reduced apoptosis in colon cancer MC38 cells. [PLoS One] Full Article

INTESTINAL STEM CELL & ORGANOID RESEARCH

Sex Difference in Pathology of the Aging Gut Mediates the Greater Response of Female Lifespan to Dietary Restriction
Investigators uncovered a substantial sex difference in the pathology of the aging gut in Drosophila. The intestinal epithelium of the aging female undergoes major deterioration, driven by intestinal stem cell (ISC) division, while lower ISC activity in males associates with delay or absence of pathology, and better barrier function, even at old ages. [eLife] Full Article

Quantifying Lgr5-Positive Stem Cell Behavior in the Pyloric Epithelium
Using in vivo lineage tracing data researchers quantified clonal expansion as well as proliferation and differentiation of the Lgr5-positive stem cell population in pyloric gastric glands. [Sci Rep] Full Article

A Versatile Strategy for Isolating a Highly Enriched Population of Intestinal Stem Cells
Scientists introduce a combinational cell surface marker-mediated strategy that allows the isolation of an intestinal stem cell (ISC) population transcriptionally and functionally equivalent to the gold standard Lgr5-GFP ISCs. [Stem Cell Reports] Full Article | Graphical Abstract

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Atlantic Healthcare Starts Pivotal Phase III trial of Alicaforsen to Treat Inflammatory Bowel Disease Pouchitis
Atlantic Healthcare Plc announced that patient recruitment has commenced for a Phase III trial of its wholly-owned product alicaforsen enema to treat inflammatory bowel disease pouchitis. [Atlantic Healthcare plc] Press Release

Government of Canada Invests in Research Commercialization
The Centre for Commercialization of Cancer Immunotherapy will receive funding of $15 million over five years to develop, translate and commercialize cancer immunotherapy. [Networks of Centres of Excellence of Canada] Press Release

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Postdoctoral Position – Immunology of Inflammatory Bowel Disease (University of California, San Diego)

Postdoctoral Fellowship – Inflammatory Bowel Disease (Linköping University)

Postdoctoral Position – Tumor Immunology (Medical University of South Carolina)

Research Associate – Autoimmunity (The Scripps Research Institute)

Postdoctoral Fellowship – Immunology (Beth Israel Deaconess Medical Center)

Gastroenterologist – Inflammatory Bowel Disease (Mayo Clinic)

Postdoctoral Associate – Biomedical and Single Cell Genomics (Cornell University)

Faculty Position – Gastrointestinal Physiology (University of Ottawa)

Postdoctoral Position – Gut Inflammation and IBD (University College Cork)

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