Intestinal Cell News Volume 3.08 | Mar 3 2017

TOP STORY

An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk

The authors devised a microfabricated organ culture system that viably preserves the normal multicellular composition of the mouse intestine, with luminal flow to control perturbations. It enables studying short-term responses of diverse gut components. [Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

INTESTINAL CANCERS & DISEASES

IL-33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment

Investigators showed that IL-33 is expressed by vascular endothelial cells and tumor cells in the human colon cancer microenvironment. Administration of human IL-33 and overexpression of murine IL-33 enhanced human and murine colon cancer cell growth in vivo, respectively. IL-33 stimulated cell sphere formation and prevented chemotherapy-induced tumor apoptosis. [Cancer Res] Abstract

LIGHT Elevation Enhances Immune Eradication of Colon Cancer Metastases

The authors reported that the immunostimulatory cytokine LIGHT in the microenvironment of colon cancer metastases associates with improved patient survival. They demonstrated, in an immunocompetent murine model, that colon tumors expressing LIGHT stimulate lymphocyte proliferation and tumor-cell specific anti-tumor immune responses. [Cancer Res] Abstract

CRIF1 Enhances p53 Activity via the Chromatin Remodeler SNF5 in the HCT116 Colon Cancer Cell Lines

Scientists found that CR6-interacting factor 1 (CRIF1) could be recruited to a specific region in the promoter of the p53 gene, eliciting an increase in the mRNA and protein levels of p53 as well as p53 functional target genes. These functions required CRIF1 to interact with SNF5. CRIF1 was further recruited to the upstream promoter region of the p53 gene to suppress cell cycle progression in HCT116 cells [Biochim Biophys Acta] Full Article

Effect of Hops Derived Prenylated Phenols on TNF-α Induced Barrier Dysfunction in Intestinal Epithelial Cells

For the prenylated hops phenols 6- and 8-prenylnaringenin, xanthohumol, and isoxanthohumol, a variety of biological activities has been described. A transwell based in vitro model using the human intestinal epithelial cell line Caco-2 was developed to assess potential beneficial effects of compounds 1–4 on TNF-α-induced impairment of tight junction permeability. [J Nat Prod] Abstract | Graphical Abstract

Three-Dimensional Organotypic Co-Culture Model of Intestinal Epithelial Cells and Macrophages to Study Salmonella enterica Colonization Patterns

To enhance the physiological relevance of three-dimensional models to more closely approximate in vivo intestinal microenvironments encountered by Salmonella, scientists developed and validated a novel three-dimensional co-culture infection model of colonic epithelial cells and macrophages using the NASA Rotating Wall Vessel bioreactor. [npj Microgravity] Full Article

INTESTINAL STEM CELL & ORGANOID RESEARCH

The Role of the Hes1 Crosstalk Hub in Notch-Wnt Interactions of the Intestinal Crypt

Researchers propose a new mathematical model of the Notch and Wnt pathways, in which the Hes1 promoter acts as a hub for pathway crosstalk. Computational simulations of the model can assist in understanding how healthy intestinal tissue is maintained, and predict the likely consequences of biochemical knockouts upon cell fate selection processes. [PLoS Comput Biol] Full Article

A Fish Intestinal Epithelial Barrier Model Established from the Rainbow Trout (Oncorhynchus mykiss) Cell Line, RTgutGC

In order to exploit the opportunities arising from RTgutGC cells for exploring fish intestinal physiology and toxicology, scientists present the establishment of cells on commercially available permeable membrane supports and evaluate its suitability as a model of polarized intestinal epithelia. [Cell Biol Toxicol] Full Article

Air–Liquid Interface Enhances Oxidative Phosphorylation in Intestinal Epithelial Cell Line IPEC-J2

Researchers assessed oxygen availability in air–liquid interface (ALI) cultures and examined the influence of this cell culture method on glycolysis and oxidative phosphorylation in IPEC-J2 using the submerged membrane culture and ALI cultures. [Cell Death Discov] Full Article

Systematic Review with Meta-Analysis: The Efficacy and Safety of CT-P13, a Biosimilar of Anti-Tumor Necrosis Factor-α Agent (Infliximab), in Inflammatory Bowel Diseases

The authors performed a systematic review and meta-analysis to evaluate the efficacy and safety of biosimilars of anti-tumor necrosis factor-α agents in patients with inflammatory bowel diseases. [Aliment Pharmacol Ther] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

Chi-Med Announces Positive Top-Line Results for FRESCO, its Phase III Pivotal Registration Trial of Fruquintinib in Patients with Locally Advanced or Metastatic Colorectal Cancer

Hutchison China MediTech Limited (Chi-Med) announces top-line results from FRESCO, its Phase III pivotal registration trial of fruquintinib in 416 patients with locally advanced or metastatic colorectal cancer in China, who failed at least two prior chemotherapies, including fluoropyrimidine, oxaliplatin and irinotecan. [Hutchison China MediTech Limited] Press Release

FDA Approves Lexicon Drug XERMELO^™ (Telotristat Ethyl) 250 mg as First and Only Oral Treatment for Carcinoid Syndrome Diarrhea in Cancer Patients with Metastatic Neuroendocrine Tumors

Lexicon Pharmaceuticals, Inc. announced that the U.S. Food and Drug Administration (FDA) has approved XERMELO^™ as a first and only orally administered therapy for the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in adults inadequately controlled by SSA therapy. [Lexicon Pharmaceuticals, Inc.] Press Release

How the Fallout from Trump’s Travel Ban Is Reshaping Science

Many foreign-born scientists say they are reconsidering plans to work or study in the United States, even though federal courts have indefinitely blocked US President Donald Trump’s travel ban. The policy, which Trump signed on 27 January, sought to deny entry to citizens of seven Muslim-majority nations for 90 days — including those with valid US visas. [Nature News] Editorial

Peer-Review Activists Push Psychology Journals towards Open Data

An editor on the board of a journal published by the prestigious American Psychological Association has been asked to resign in a controversy over data sharing in peer review. Gert Storms — who says he won’t step down — is one of a few hundred scientists who have vowed that, from the start of this year, they will begin rejecting papers if authors won’t publicly share the underlying data, or explain why they can’t. [Nature News] Editorial

Senior Republican Lawmaker Has Some Advice for U.S. Science Marchers

The chairman of a congressional spending panel that oversees a wide swath of U.S. science agencies has some unusual advice for scientists planning to march on 22 April: Don’t talk about research. Instead, demand that Congress find a way to cut mandatory spending programs. [ScienceInsider] Editorial

UK Scientists Welcome Changes to Controversial Research Reforms

Amendments aim to protect autonomy and the independence of research funders from political interference. [Nature News] Editorial

NEW The Biology of Regenerative Medicine
April 25-27, 2017
Hinxton, United Kingdom

NEW AACR International Conference on Translational Cancer Medicine
May 4-6, 2017
Sao Paulo, Brazil

Visit our events page to see a complete list of events in the community.

NEW Senior Scientist – Pathology of Immunology and Gastrointestinal Diseases (Takeda Pharmaceuticals)

Postdoctoral Fellow – Unraveling Oncotherapy Stem Cell Toxicity (AstraZeneca)

Assistant & Associate Investigators – Colorectal, Pancreatic, Gastric and Esophageal Cancers (Baylor Scott & White Health)

Postdoctoral Fellow – Intestinal Pathogens on Host Development and Metabolism (Boston Children’s Hospital/Harvard Medical School)

Faculty Position – Intestinal Stem Cell Research (Duke University Division of Gastroenterology)

Postdoctoral Fellowship – Cellular Mechanisms by Which Fatty Acids Are Absorbed in the Gut (UCSF – Cardiovascular Research Institute)

Research Associate – Colorectal Cancer (University of Virginia)

Gastroenterologist(s) – General and Interventional (Temple University)

Postdoctoral Fellow – Translational Intestinal Models (Johnson & Johnson Group)

Postdoctoral Research Fellow – Intestinal Disease (Children’s Hospital Los Angeles)

Assistant Professor – Molecular Therapeutics of Cancer (Dartmouth College)

Assistant or Associate Member – Stem Cell/Gene Therapy (Fred Hutchinson Cancer Research Center)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Intestinal Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.