Intestinal Cell News Volume 4.04 | Feb 2 2018

TOP STORY

Bacteria Play Critical Role in Driving Colon Cancers

Two species may work together to drive tumor formation in hereditary colon cancer syndrome and sporadic colon cancer. [Press release from Johns Hopkins University discussing online prepublication in Science] Press Release | Abstract | Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

C1orf106 Is a Colitis Risk Gene that Regulates Stability of Epithelial Adherens Junctions

Scientists demonstrated that C1orf106 regulates adherens junction stability by regulating the degradation of cytohesin-1, a guanine nucleotide exchange factor that controls activation of ARF6. [Science] Abstract

RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3

Ring finger protein 6 (RNF6) promoted cell growth, cell cycle progression, and epithelial-to-mesenchymal transition in colorectal cancer cells; RNF6 also promoted colorectal tumor growth and lung metastasis in mouse models. [Cancer Res] Abstract

Secretory Autophagy of Lysozyme in Paneth Cells

Investigators discovered that paneth cells react to bacterial invasion by rerouting a critical secreted antibacterial protein through a macroautophagy/autophagy-based secretion system termed secretory autophagy. [Autophagy] Abstract

YAP Triggers the Wnt/β-Catenin Signaling Pathway and Promotes Enterocyte Self-Renewal, Regeneration and Tumorigenesis after DSS-Induced Injury

Researchers sought to identify the roles of yes-associated protein (YAP) in intestinal epithelial cell self-renewal, regeneration and tumorigenesis. They found that after tissue injury, YAP^WT mice had increased epithelial cell self-renewal capacity and drastically restored intestinal crypt structure. [Cell Death Dis] Full Article

Overt Increase of Oxidative Stress and DNA Damage in Murine and Human Colitis and Colitis-Associated Neoplasia

Scientists found that inflammation-driven colon carcinogenesis in IL-10 KO mice and inflammatory bowel disease patients is associated with oxidative DNA damage and overt presence of double-strand breaks. [Mol Cancer Res] Abstract | Full Article

Single Cell Analysis of Crohn’s Disease Patient-Derived Small Intestinal Organoids Reveals Disease Activity-Dependent Modification of Stem Cell Properties

Crohn’s disease patient-derived small intestinal organoids were established from enteroscopic biopsy specimens taken from active lesions, or from mucosa under remission. Expression of intestinal stem cell-marker genes in those organoids was examined by immunohistochemistry, and also by microfluid-based single-cell multiplex gene expression analysis. [J Gastroenterol] Full Article

The GS-Nitroxide JP4-039 Improves Intestinal Barrier and Stem Cell Recovery in Irradiated Mice

Researchers demonstrated that a mitochondrion-targeted nitroxide JP4-039 given once 24 hours after 9-10 Gy body irradiation significantly improves mouse survival, and the recovery of intestinal barrier, differentiation and stem cell functions. [Sci Rep] Full Article

DUSP5 Is Methylated in CIMP-High Colorectal Cancer but Is Not a Major Regulator of Intestinal Cell Proliferation and Tumorigenesis

DUSP5 depletion failed to alter ERK signaling or proliferation in colorectal cancer cell lines, and its transgenic overexpression in the mouse intestine had minimal impact on normal intestinal homeostasis or tumor development [Sci Rep] Full Article

A Mitogenic Lectin from Rhizoctonia bataticola Arrests Growth, Inhibits Metastasis and Induces Apoptosis in Human Colon Epithelial Cancer Cells

Investigators report the effect of Rhizoctonia bataticola on human colon cancer HT 29, SW480 and SW620 cell growth and its differential binding to human normal colon and cancer tissues. [J Cell Biochem] Abstract

Effects of Six Common Dietary Nutrients on Murine Intestinal Organoid Growth

Scientists found that caffeic acid inhibited organoid growth in a concentration-dependent manner, curcumin exhibited variable effectiveness, and vitamin C had no effect on organoid growth. [PLoS One] Full Article

Circulating Tumor Cell-Derived Organoids: Current Challenges and Promises in Medical Research and Precision Medicine

The authors focus on advances in circulating tumor cell isolation and organoid culture methods, and their potential applications in disease modeling and precision medicine. [Biochim Biophys Acta] Full Articlet

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

SillaJen Announces First Patient Enrolled in the NCI-Sponsored Trial Evaluating Combination Therapy in Colorectal Cancer with SillaJen’s Pexa-Vec Oncolytic Immunotherapy

SillaJen, Inc. announced the initiation of a Phase I/II clinical trial of pexastimogene devacirepvec in combination with checkpoint inhibitor therapy for the treatment of metastatic colon cancer. [SillaJen, Inc. (PR Newswire Association LLC)] Press Release

Treos Bio Announces FDA Approval of IND of Its First PolyPEPI^™ Precision Cancer Vaccine for Metastatic Colorectal Cancer

Treos Bio Limited announced that the FDA has accepted its Investigational New Drug (IND) Application for PolyPEPI^™ 1018, its investigational precision cancer vaccine for patients with metastatic colorectal cancer (mCRC), and has provided authorization to proceed with the Phase I study in mCRC patients. [Treos Bio Limited] Press Release

Watch the Video Now
Learn the basics of culturing mouse intestinal organoids with an instructional video series.

Bulgaria in the Cold as European Union Freezes Its Funding

European Union science ministers are due to meet in their bloc’s poorest member state — Bulgaria — to discuss future EU research policy. For the host nation, it was supposed to be a chance to showcase its ambitious plans to boost economic growth by attracting international research institutes to the country. [Nature News] Editorial

Kid Co-Authors in South Korea Spur Government Probe

The South Korean government is expanding an investigation into researchers who named their children as co-authors on papers. The extended probe comes after a government report identified 82 academic papers on which authors had named their children or relatives — many of them in middle or high school — as co-authors on the publications. [Nature News] Editorial

NEW 8^th EACR-OECI Joint Course: Molecular Pathology Approach to Cancer
June 4-6, 2018
Amsterdam, Netherlands

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NEW Postdoctoral Fellow – Cancer Biology (Johns Hopkins University)

Postdoctoral Fellow – Cancer Biology (University of Arkansas for Medical Science)

Postdoctoral Research Associate – Cancer Biology (King’s College London)

Postdoctoral Position – Intestinal Epithelial Cell Biology and Apical Defense Mechanisms (University of Gothenburg)

Postdoctoral Position – Inflammatory Bowel Disease (KU Leuven)

Postdoctoral Fellowship – Mouse Tumor Biology (Canadian Nuclear Laboratories)

Postdoctoral Research Scientist – Cancer Research (The Cancer Research UK Beatson Institute)

Senior Clinical Researcher – Gastro-Intestinal Pathology (University of Oxford)

Postdoctoral Position – Intestinal Research (University of Pennsylvania)

Postdoctoral Fellowship – Mouse Tumor Biology (Canadian Nuclear Laboratories)

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