Intestinal Cell News Volume 4.10 | Mar 16 2018

TOP STORY

PLK1 Has Tumor-Suppressive Potential in APC-Truncated Colon Cancer Cells

The expression of adenomatous polyposis coli (APC) truncation in colon cells reduced the accumulation of mitotic cells upon polo-like kinase 1 (PLK1) inhibition, accelerated mitotic exit and increased the survival of cells with enhanced chromosomal abnormalities. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis

Investigators found that PCNA-associated factor (PAF) is expressed in intestinal stem and progenitor cells and markedly upregulated during intestinal regeneration and tumorigenesis. [Dev Cell] Abstract | Graphical Abstract

APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway

Researchers showed that Adenomatous polyposis coli (APC) exists in a complex with clathrin and that Wnt pathway activation in APC-deficient cells requires clathrin-mediated endocytosis. They demonstrated conservation of this mechanism in Drosophila intestinal stem cells. [Dev Cell] Full Article | Graphical Abstract

Loss of FFAR2 Promotes Colon Cancer by Epigenetic Dysregulation of Inflammation Suppressors

Free fatty acid receptor 2 (FFAR2) deficiency promoted the development of colon adenoma in the Apc^Min/+/dextran sodium sulfate (DSS) mice and the progression of adenoma to adenocarcinoma in the azoxymethane/DSS mice. [Int J Cancer] Abstract

Linc00659, a Long Noncoding RNA, Acts as Novel Oncogene in Regulating Cancer Cell Growth in Colorectal Cancer

Scientists investigated the transcriptome profiles of human long noncoding RNAs in the primary tumor tissues and in the corresponding normal mucosa of two patients with colorectal cancer by using a microarray approach. The effects of Linc00659 on cell growth, proliferation, cell cycle and apoptosis were studies by in vitro assays. [Mol Cancer] Full Article

miR-381-3p Knockdown Improves Intestinal Epithelial Proliferation and Barrier Function after Intestinal Ischemia/Reperfusion Injury by Targeting Nurr1

Investigators assessed the effect of nuclear receptor-related protein 1 (nurr1) on intestinal barrier function and evaluated miRNA-nurr1-mediated restoration of intestinal barrier function in intestinal ischemia/reperfusion injury. [Cell Death Dis] Full Article

The Mitochondrially Targeted Antioxidant MitoQ Protects the Intestinal Barrier by Ameliorating Mitochondrial DNA Damage via the Nrf2/ARE Signaling Pathway

In both in vivo and in vitro studies, scientists found that MitoQ pretreatment downregulated ischemia reperfusion (I/R)-induced oxidative stress and stabilized the intestinal barrier, as evidenced by MitoQ-treated I/R mice exhibiting attenuated intestinal hyperpermeability, inflammatory response, epithelial apoptosis, and tight junction damage compared to controls. [Cell Death Dis] Full Article

Autophagy Maintains Stem Cells and Intestinal Homeostasis in Drosophila

Autophagy was required in Drosophila intestinal stem cells to sustain proliferation, and preserve the stem cell pool. Autophagy-deficient stem cells showed elevated DNA damage and cell cycle arrest during aging, and were frequently eliminated via JNK-mediated apoptosis. [Sci Rep] Full Article

The Effect of S100A6 on Nuclear Translocation of CacyBP/SIP in Colon Cancer Cells

The authors tested whether the Ca²⁺-dependent binding partner S100 protein is involved in calcyclin binding protein/siah-1 interacting protein (CacyBP/SIP) nuclear translocation in colon cancer SW480 cells. [PLoS One] Full Article

Immunopathogenesis of Inflammatory Bowel Disease and Mechanisms of Biological Therapies

Scientists review the aspects of the immunopathogenesis of inflammatory bowel disease, with focus on mucosal immunity, and discuss mechanisms of action for current and emerging biological therapies. [Scand J Gastroenterol] Full Article

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

Boehringer Ingelheim and Vanderbilt University Expand Partnership to Develop Novel Treatment Approaches for Cancer

Boehringer Ingelheim and Vanderbilt University announced the expansion of their successful existing collaboration to develop novel anti-cancer compounds. The expanded research partnership will focus on the discovery and development of new chemical therapeutics targeting the pro-survival protein MCL1 as a potential therapy against MCL1-dependent cancers. [Vanderbilt University] Press Release

MD Anderson and Berkeley Lights Launch Optera Therapeutics to Accelerate Development of Cell Therapies for Cancer

The University of Texas MD Anderson Cancer Center and Berkeley Lights, Inc. announced the launch of Optera Therapeutics Corp, a biopharmaceutical company developing cell therapies with scalable manufacturing solutions for cancer. [The University of Texas MD Anderson Cancer Center] Press Release

Learn the basics of culturing mouse intestinal organoids with an instructional video series. Watch the Video Now

Scientists Beware: The Price Is High, the Payoff Uncertain at Glossy Publications Aimed at Europe’s Decision-Makers

Van der Heyden isn’t the only European researcher to get a hard sell from Pan European Networks, a six-year-old publishing company with offices in Congleton, U.K., and Brussels that promises to provide opportunities for “leading figures from across Europe” to get attention for their work or ideas. Many other scientists had similar experiences, Van der Heyden discovered when he started poking around on blogs and Twitter, including the promise of attention from decision-makers and the warning about the imminent board meeting. [ScienceInsider] Editorial

‘Right-to-Try’ Bill Rejected by House, in Major Blow to GOP Efforts

In a major blow to the effort to pass a federal “right-to-try” law, House Republicans failed to muster the votes to pass a key compromise measure. [STAT News] Editorial

Springer Nature and VSNU Renew Agreement on Open Access Publishing

Springer Nature and the Association of Universities in the Netherlands (VSNU) have renewed their agreement to secure open access publishing for Dutch universities up to 2021. [The Association of Universities in the Netherlands] Editorial

Science ‘Champion’ Dan Lipinski Faces Tough Race in Illinois Primary

Representative Daniel Lipinski—an anti-abortion Democrat who voted against the Affordable Care Act and who only recently has embraced a path to citizenship for undocumented immigrants—knows that he’s out of step with progressives on many social issues. Lipinski will find out whether voters in Illinois’s third congressional district on Chicago’s southwest side feel there’s still room for him in the Democratic Party. [ScienceInsider] Editorial

NEW Gordon Research Conferences: Cell Death
August 5-10, 2018
Newry, Maine, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Fellow – Colon Cancer (Health Sciences North Research Institute)

Postdoctoral Research Fellow – Lysosomes in Neonatal Enterocytes and Their Pathologies (Northwestern University)

Director Position – Immune Intestinal Homeostasis (Institute for Basic Science)

Postdoctoral Fellow – Mucosal Immunology (Centre of Molecular Inflammation Research)

Postdoctoral Position – Molecular Biology/Signal Transduction/ Cancer/Inflammation (Universite de Liege)

Academic Positions – Inflammatory Bowel Disease (Cedars-Sinai Inflammatory Bowel and Immunobiology Research Institute)

Clinical Research Training Fellowship – Gastro-Intestinal Pathology with Scientific Research (University College London)

Postdoctoral Fellow – Inflammatory Bowel Disease (Marshall University)

Postdoctoral Position – Host-Microbe Interactions and Intestinal Cancer (VIB Center for Inflammation Research)

Postdoctoral Fellow – Cancer Biology (Johns Hopkins University)

Postdoctoral Fellow – Cancer Biology (University of Arkansas for Medical Science)

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