Intestinal Cell News Volume 4.11 | Mar 23 2018

TOP STORY

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner

Researchers showed that NF-κB1 deficiency, even loss of a single allele, resulted in spontaneous invasive gastric cancer in mice that mirrored the histopathological progression of human intestinal-type gastric adenocarcinoma. [Immunity] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Wnt Ligands Influence Tumor Initiation by Controlling the Number of Intestinal Stem Cells

Reduction of Wnt ligand secretion accelerates fixation of Apc-deficient cells within the crypt leading to accelerated tumorigenesis. Therefore, ligand-based Wnt signaling influenced the number of stem cells, fixation speed of Apc mutations and the speed and likelihood of adenoma formation. [Nat Commun] Full Article

PDGFRα⁺ Pericryptal Stromal Cells Are the Critical Source of Wnts and RSPO3 for Murine Intestinal Stem Cells In Vivo

Scientists investigated both the source and the functional role of stromal Wnts and Wnts and R-spondin (RSPO) in regulation of intestinal homeostasis. RSPO3 was highly expressed in pericryptal myofibroblasts in the lamina propria and is several orders of magnitude more potent than RSPO1 in stimulating both Wnt/β-catenin signaling and organoid growth. [Proc Natl Acad Sci USA] Full Article

CREPT Facilitates Colorectal Cancer Growth through Inducing Wnt/β-Catenin Pathway by Enhancing p300-Mediated β-Catenin Acetylation

Multivariate analysis showed that colorectal cancer (CRC) patients with CREPT protein overexpression were significantly associated with poor disease-free survival. CREPT significantly accelerated CRC cell proliferation and metastasis both in vitro and in vivo. [Oncogene] Full Article

β-Catenin Knockdown Promotes NHERF1-Mediated Survival of Colorectal Cancer Cells: Implications for a Double-Targeted Therapy

Using human colorectal cancer (CRC) cells harboring different Wnt/β-catenin pathway mutations in APC/KRAS or β-catenin/KRAS genes, and both genetic and pharmacological knockdown approaches, the authors showed that oncogenic β-catenin signaling negatively regulates the expression of Na⁺/H⁺ exchanger 3 regulating factor 1 (NHERF1), a PDZ-adaptor protein that is usually lost or downregulated in early dysplastic adenomas to exacerbate nuclear β-catenin activity. [Oncogene] Full Article

The Intestinal Stem Cell Regulating Gene ASCL2 Is Required for L1-Mediated Colon Cancer Progression

In L1 overexpressing colorectal cancer (CRC) cells scientists found an increase in ASCL2, a decrease in E-cadherin and accumulation of nuclear β-catenin, β-catenin-LEF1/TCF transactivation and target gene expression. [Cancer Lett] Abstract

Nuclear Receptor Binding Protein 1 Correlates with Better Prognosis and Induces Caspase-Dependent Intrinsic Apoptosis through the JNK Signaling Pathway in Colorectal Cancer

Investigators observed that nuclear receptor binding protein 1 (NRBP1) expression levels were significantly reduced in colorectal cancer (CRC) tissues compared with corresponding adjacent normal tissues, and high NRBP1 expression correlated with better prognosis in CRC. Overexpression of NRBP1 inhibited CRC cell proliferation and promoted apoptosis in vitro and in vivo. [Cell Death Dis] Full Article

Nucleotide-Mediated SPDEF Modulates TFF3-Mediated Wound Healing and Intestinal Barrier Function during the Weaning Process

Researchers evaluated the molecular mechanisms regulating the effects of nucleotides on weaning. Nucleotide treatment induced trefoil factor 3 (TFF3) expression and IPEC-J2 cell growth and reduced wound width. Treatment with nucleosides and TFF3 in lipopolysaccharide-challenged IPEC-J2 cells increased intestinal transepithelial electrical resistance and decreased intestinal permeability. [Sci Rep] Full Article

Cartilage Oligomeric Matrix Protein Is a Prognostic Factor and Biomarker of Colon Cancer and Promotes Cell Proliferation by Activating the Akt Pathway

Colon cancer cells without cartilage oligomeric matrix protein were defective with respect to the ability to proliferate, colony formation, the ability to resist 5-fluorouracil-induced apoptosis and the growth of xenograft tumors in mice. [J Cancer Res Clin Oncol] Abstract

Mechanisms for Intestinal Regeneration

Scientists summarize the notable structures and pathways in intestinal epithelial growth before presenting the current main areas of active research in intestinal regeneration. [Curr Opin Pediatr] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

Merus and the Vall d’Hebron Institute of Oncology Announce Research Collaboration to Develop Innovative Bispecific Antibodies for Therapeutic Applications in the Treatment of Cancer

Merus N.V. and the Vall d’Hebron Institute of Oncology announced a strategic research collaboration to develop novel agents for therapeutic applications. [Merus N.V.] Press Release

CGT Catapult to Support UK Network of Advanced Therapies Treatment Centers

The Cell and Gene Therapy (CGT) Catapult will support three UK sites awarded funding to form a network of advanced therapies treatment centers – joint ventures set up to include industry, academic and NHS partners, and funded by Innovate UK. [The Cell and Gene Therapy Catapult] Press Release

Dr. Sylvia Boj details the use of organoids as model systems in drug screening and personalized medicine. Watch Now

Final 2018 Budget Deal Should Help the National Science Foundation in 2019, Too

The 4% increase for the National Science Foundation (NSF) in Alexandria, Virginia, in the 2018 omnibus spending bill hammered out by congressional leaders may be modest next to what its peer science agencies received. But it does offer NSF officials more breathing room to fund some major initiatives starting next year. [ScienceInsider] Editorial

Expectations Are High for UKRI, the United Kingdom’s New £6 Billion Research Behemoth

Combine U.S. agencies akin to the National Institutes of Health, National Science Foundation, and National Endowment for the Humanities. Toss in some energy and innovation research and fuel it all with the largest boost in R&D spending in recent history. Then put one person in charge. [ScienceInsider] Editorial

HIV Researcher Is New Head of US Public-Health Agency

HIV researcher Robert Redfield will lead the Centers for Disease Control and Prevention, Secretary of Health and Human Services Alex Azar announced. [Nature News] Editorial

NEW Gordon Research Conferences: Cell Death
August 5-10, 2018
Newry, Maine, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellowship – Intestinal Cancer (University of Gothenburg)

Postdoctoral Research Fellow – Colon Cancer (Health Sciences North Research Institute)

Postdoctoral Research Fellow – Lysosomes in Neonatal Enterocytes and Their Pathologies (Northwestern University)

Director Position – Immune Intestinal Homeostasis (Institute for Basic Science)

Postdoctoral Fellow – Mucosal Immunology (Centre of Molecular Inflammation Research)

Postdoctoral Position – Molecular Biology/Signal Transduction/ Cancer/Inflammation (Universite de Liege)

Academic Positions – Inflammatory Bowel Disease (Cedars-Sinai Inflammatory Bowel and Immunobiology Research Institute)

Clinical Research Training Fellowship – Gastro-Intestinal Pathology with Scientific Research (University College London)

Postdoctoral Fellow – Inflammatory Bowel Disease (Marshall University)

Postdoctoral Position – Host-Microbe Interactions and Intestinal Cancer (VIB Center for Inflammation Research)

Postdoctoral Fellow – Cancer Biology (Johns Hopkins University)

Postdoctoral Fellow – Cancer Biology (University of Arkansas for Medical Science)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Intestinal Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.