Intestinal Cell News Volume 4.32 | Aug 24 2018

TOP STORY

Interaction between Smoking and ATG16L1^T300A Triggers Paneth Cell Defects in Crohn’s Disease

Investigators found that both Crohn’s disease subjects and mice with ATG16L1^T300A developed Paneth cell defects triggered by tobacco smoke. [J Clin Invest] Abstract | Full Article

(Ranked by impact factor of the journal)

TRIM27 Mediates STAT3 Activation at Retromer-Positive Structures to Promote Colitis and Colitis-Associated Carcinogenesis

Overexpression of TRIM27 promoted cancer cell growth in vitro and tumor growth in nude mice, whereas knockdown of TRIM27 had opposite effects. [Nat Commun] Full Article

Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche

Scientists found that intestinal myofibroblasts are intrinsically resistant to multiple xenobiotics, including PORCN inhibitors and the anthracycline antibiotic doxorubicin. These myofibroblasts had high expression of a subset of drug transporters; knockout of Mrp1/Abcc1 enhanced drug sensitivity. [Dev Cell] Abstract | Press Release | Graphical Abstract

A Simple System for Differentiation of Functional Intestinal Stem Cell-Like Cells from Bone Marrow Mesenchymal Stem Cells

Investigators developed a two-step protocol in which mesenchymal stem cells were first induced into Sox17- or Foxa2-positive definitive endoderm cells by activin A treatment and then into Lgr5-positive intestinal stem cell-like cells by miR-17 and FGF2 treatment. [Mol Ther Nucleic Acids] Abstract | Full Article

The Tyrosine Phosphorylated Pro-Survival Form of Fas Intensifies the EGF-Induced Signal in Colorectal Cancer Cells through the Nuclear EGFR/STAT3-Mediated Pathway

Scientists showed that Fas in its pro-survival state, phosphorylated at Y291, functionally interacts with the epidermal growth factor receptor (EGFR), a key cancer-driving protein and major therapeutic target. [Sci Rep] Full Article

Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine

Researchers generated intestinal epithelial cells from human induced pluripotent stem cells and then clarified whether the functions of hydrolase and transporters in them reflect oral drug absorption in the small intestine. [Drug Metab Dispos] Abstract | Full Article

The Dietary Flavone Luteolin Epigenetically Activates the Nrf2 Pathway and Blocks Cell Transformation in Human Colorectal Cancer HCT116 Cells

The authors showed that luteolin suppressed cell proliferation and cellular transformation of HCT116 and HT29 cells in a dose‐dependent manner. [J Cell Biochem] Abstract

Crocin Synergistically Enhances the Antiproliferative Activity of 5‐Fluorouracil through Wnt/PI3K Pathway in a Mouse Model of Colitis‐Associated Colorectal Cancer

Crocin suppressed cell‐growth and the invasive behavior of colorectal cancer cells through modulation of the Wnt‐pathway and E‐cadherin. Moreover, administration of crocin alone, or in combination with 5-fluorouracil dramatically reduced the tumor number and tumor size in both distal/mid‐colon followed by reduction in disease‐activity index. [J Cell Biochem] Abstract

Apelin Effects Migration and Invasion Abilities of Colon Cancer Cells

Researchers showed that the effect of four different apelin peptides increased the ability of cancer cells to migrate and invade examined cells through influencing migratory protrusions formation and actin cytoskeleton rearrangement. [Cells] Full Article

Inducible Nitric Oxide Regulates Brush Border Membrane Na-Glucose Co-Transport, but Not Na:H Exchange via p38 MAP Kinase in Intestinal Epithelial Cells

Scientists determined the effect of peroxynitrite on Na-glucose co-transport and Na/H exchange in small intestinal epithelial cell monolayers grown on trans well plates. [Cells] Full Article

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Reserve Stem Cells in Intestinal Homeostasis and Injury

The authors review models used to study the mechanisms by which intestinal stem cells fuel the rapid turnover of the epithelium during homeostasis and might support epithelial regeneration after injury. [Gastroenterology] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

Telix Pharmaceuticals, University of Melbourne and Peter Mac to Collaborate on Colorectal Cancer

Telix Pharmaceuticals Limited announced a research collaboration with the University of Melbourne to investigate the use of targeted radiopharmaceuticals or “molecularly-targeted radiation” to provide improved treatments for colorectal cancer patients. [Telix Pharmaceuticals (GlobeNewswire, Inc)] Press Release

Innovate Biopharmaceuticals Enters into an Agreement with Amarex Clinical Research for Data Management and Biostatistics for Phase III Celiac Disease Trial

Innovate Biopharmaceuticals, Inc. announced it signed an agreement with Amarex Clinical Research to provide data management and biostatistics for its planned Phase III celiac disease trial. [Innovate Biopharmaceuticals, Inc.] Press Release

Approval of Linzess^® Tablets 0.25 mg in Japan for Additional Indication of Chronic Constipation

Astellas Pharma Inc. and Ironwood Pharmaceuticals, Inc. announced that approval has been obtained in Japan for the guanylate cyclase-C receptor agonist Linzess^® tablets for the additional indication of chronic constipation. [Astellas Pharma Inc.] Press Release

Learn the basics of culturing mouse intestinal organoids with an instructional video series. Watch the Video Now

Europe’s First Allogeneic Stem Cell Therapy Rejected by NICE

Cost regulators for the NHS in England and Wales have not approved funding for TiGenix and Takeda’s Alofisel – the first allogeneic stem cell therapy to be approved for use across the European Union – for use in Crohn’s patients. [PharmaTimes] Editorial

Senate Approves $2B Boost for NIH in $850B+ Spending Bill

For the fourth year in a row, the Senate has approved a significant increase in funding for the National Institutes of Health (NIH). [Fierce Biotech] Editorial

NIH Is Investigating Researchers Who Might Have Failed to Disclose Contributions from Foreign Governments

The National Institutes of Health (NIH) is investigating roughly a half-dozen research institutions based on suspicions that researchers with federal grants failed to disclose significant financial contributions from foreign governments. [STAT News] Editorial

NEW Lorne Cancer Conference 2019
February 14-16, 2019
Lorne, Australia

Visit our events page to see a complete list of events in the community.

NEW PhD Student – Colorectal Cancer (German Cancer Research Center)

Postdoctoral Scholar – Intestinal Research (Penn State College of Medicine)

Postdoctoral Position – Host-Microbiome Interactions in the Gastrointestinal Tract (University of Gothenburg)

Postdoctoral Associate – Functional Genomics of Inflammatory Bowel Disease (Center for Computational and Integrative Biology)

Postdoctoral Fellow – Signal Transduction of Intestinal Cells (Mornell Chemical Senses Center)

Postdoctoral Fellow – Colon Cancer (Vanderbilt University Medical Center)

Assistant/Associate Research Professor – Inflammatory Bowel Disease (Cedars-Sinai Inflammatory Bowel & Immunobiology Research Institute)

Postdoctoral Position – Paneth Cells (Erasmus MC Cancer Institute)

Postdoctoral Scholar – Molecular and Cell Biology (University of California, Berkeley)

Assistant Professor – Cancer Biology (Université de Genève)

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