Intestinal Cell News Volume 4.36 | Sep 21 2018

TOP STORY

LncGata6 Maintains Stemness of Intestinal Stem Cells and Promotes Intestinal Tumorigenesis

Scientists showed that a Gata6 long noncoding RNA (lncGata6) was highly expressed in intestinal stem cells (ISCs). LncGata6 knockout or conditional knockout in ISCs impairs the stemness of ISCs and epithelial regeneration. [Nat Cell Biol] Abstract

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IL-33 Promotes Recovery from Acute Colitis by Inducing miR-320 to Stimulate Epithelial Restitution and Repair

The authors showed that IL-33 stimulates the expression of a network of microRNAs in the Caco2 colonic intestinal epithelial cell (IEC) line, especially miR-320, which is increased by >16-fold in IECs isolated from IL-33-treated vs. vehicle-treated dextran sodium sulfate colitic mice. [Proc Natl Acad Sci USA] Abstract

Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation

Researchers employed a model of epithelial-specific, heterozygous Grp78 deletion by use of VillinCreERT2-Rosa26ZsGreen/LacZ-Grp78⁺/fl mice and organoids. They examined models of irradiation and tumorigenesis both in vitro and in vivo. [Cancer Res] Abstract

Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis

Investigators identified a role for the E3 ubiquitin ligase RNF5 in inflammatory bowel disease. Intestinal epithelial cells express a high level of RNF5, while the colon of Rnf5^−/− mice exhibits activated dendritic cells and intrinsic inflammation. [Cell Rep] Full Article | Graphical Abstract

Two-Photon Microscopy of Paneth Cells in the Small Intestine of Live Mice

Researchers developed a simple in vivo imaging method of Paneth cells in the intact mouse small intestine by using moxifloxacin and two-photon microscopy. [Sci Rep] Full Article

Targeting Nonsense-Mediated mRNA Decay in Colorectal Cancers with Microsatellite Instability

The authors evaluated the functional consequences of nonsense-mediated mRNA decay activity in a subgroup of colorectal cancers characterized by high levels of mRNAs with a premature termination codon due to widespread instability in microsatellite sequences. [Oncogenesis] Full Article

FABP7 Promotes Cell Proliferation and Survival in Colon Cancer through MEK/ERK Signaling Pathway

Investigators found that fatty acid binding protein 7 (FABP7) was highly expressed in colon cancer (CC) tissues and cell lines, suggesting the possible involvement of FABP7 in CC tumorigenesis. [Biomed Pharmacother] Abstract

Let-7b Attenuates Cisplatin Resistance and Tumor Growth in Gastric Cancer by Targeting AURKB

A cisplatin-resistant gastric cancer cell line with stable enhanced expression or knockdown of let-7b was generated. MTT and TUNEL assays were carried out to assess whether miR-let-7 is crucial for cell viability and apoptosis, respectively. [Cancer Gene Ther] Abstract

Microbiota-Sensitive Epigenetic Signature Predicts Inflammation in Crohn’s Disease

Researchers reveal a histone methylation signature of intestinal epithelial cells isolated from the terminal ilea of newly diagnosed pediatric inflammatory bowel disease patients. Genes characterized by significant alterations in histone H3-lysine 4 trimethylation showed differential enrichment in pathways involving immunoregulation, cell survival and signaling, and metabolism. [JCI Insight] Abstract | Press Release

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Progress and Potential in Organoid Research

Recent studies have demonstrated that organoids can be used to model organ development and disease and have a wide range of applications in basic research, drug discovery and regenerative medicine. Researchers are now beginning to take inspiration from other fields, such as bioengineering, to generate organoids that are more physiologically relevant and more amenable to real-life applications. [Nat Rev Genet] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

Propanc Biopharma Enters into Research Collaboration Agreement with the University of Jaén

Propanc Biopharma, Inc. announced the execution of a research collaboration agreement with the University of Jaén for the provision of research services and scientific technical advice for the company’s POP1 drug discovery program. [Propanc Biopharma, Inc] Press Release

The Bruce and Cynthia Sherman Charitable Foundation Announces Recipients of 2018 Sherman Prizes, Rewarding Outstanding Achievements in Crohn’s Disease and Ulcerative Colitis

The Bruce and Cynthia Sherman Charitable Foundation announced the recipients of the 2018 Sherman Prizes, recognizing outstanding contributions in the fight to overcome Crohn’s disease and ulcerative colitis, also known as inflammatory bowel diseases. [The Bruce and Cynthia Sherman Charitable Foundation] Press Release

Dr. Caroline Lindemans explains her work on intestinal repair following injury in graft versus host disease. Listen Now

Researchers Take Action to End Airlines’ Restrictions on Lab Animals

In a recently filed complaint to the US Department of Transportation, the National Association for Biomedical Research accuses four major airlines of illegally discriminating against customers wishing to fly animals destined for the lab. [The Scientist] Editorial

More and More Scientists Are Preregistering Their Studies. Should You?

Preregistration, in its simplest form, is a one-page document answering basic questions such as: What question will be studied? What is the hypothesis? What data will be collected, and how will they be analyzed? In its most rigorous form, a “registered report,” researchers write an entire paper, minus the results and discussion, and submit it for peer review at a journal, which decides whether to accept it in principle. [ScienceInsider] Editorial

This Research Group Seeks to Expose Weaknesses in Science—and They’ll Step on Some Toes If They Have To

Metaresearchers investigate how scientists operate, and how they can slip off the rails. Their main focus is questionable research practices, such as massaging data and selective reporting of statistical tests. [ScienceInsider] Editorial

NEW 2019 World Stem Cell Summit
January 22-25, 2019
Miami, Florida, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Molecular Biology/Signal Transduction/Cancer/Inflammation (Université de Liege)

Group Leader – Organoid Modeling of Disease (European Molecular Biology Laboratory)

Postdoctoral Position – Colon Cancer Research (Vanderbilt University Medical Center)

Postdoctoral Research Scientist – Gastrointestinal Disorder Research (Quadram Institute Bioscience)

Senior Scientific Officer – Colorectal Cancer (Cancer Research UK Beatson Institute)

PhD Student – Colorectal Cancer (German Cancer Research Center)

Postdoctoral Scholar – Intestinal Research (Penn State College of Medicine)

Postdoctoral Position – Host-Microbiome Interactions in the Gastrointestinal Tract (University of Gothenburg)

Postdoctoral Associate – Functional Genomics of Inflammatory Bowel Disease (Center for Computational and Integrative Biology)

Assistant/Associate Research Professor – Inflammatory Bowel Disease (Cedars-Sinai Inflammatory Bowel & Immunobiology Research Institute)

Postdoctoral Position – Paneth Cells (Erasmus MC Cancer Institute)

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