Intestinal Cell News Volume 6.28 | July 31 2020

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    Justin.choi
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    2020-07-31 | ICN 6.27


    Intestinal Cell News by STEMCELL Technologies
    Vol. 6.27 – 31 July, 2020
    TOP STORY

    Microbiota-Derived Metabolite Promotes HDAC3 Activity in the Gut

    Intestinal exposure to inositol trisphosphate and phytate ingestion both promoted recovery following intestinal damage. Remarkably, inositol trisphosphate also induced growth of patient-derived intestinal organoids, stimulated histone deacetylase 3-dependent proliferation, and countered butyrate inhibition of colonic growth.
    [Nature]

    Abstract

    Virtual Conference Exhibition: Organoids
    PUBLICATIONSRanked by the impact factor of the journal

    Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

    The authors demonstrated that the Hippo kinases LATS1/2 and MST1/2, which inhibited YAP activity, were required for maintaining Wnt signaling and canonical stem cell function.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    LINC00941 Promotes CRC Metastasis through Preventing SMAD4 Protein Degradation and Activating the TGF-β/SMAD2/3 Signaling Pathway

    LINC00941 was found to activate EMT by directly binding the SMAD4 protein MH2 domain and competing with β-TrCP to prevent SMAD4 protein degradation, thus activating the TGF-β/SMAD2/3 signaling pathway.
    [Cell Death & Differentiation]

    Abstract

    Cycling Stem Cells Are Radioresistant and Regenerate the Intestine

    The authors demonstrated that the DNA damage-resistant Msi1+ cells were cycling intestinal stem cells that maintained and regenerated the intestinal epithelium.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Mir-3622a-3p Acts as a Tumor Suppressor in Colorectal Cancer by Reducing Stemness Features and EMT through Targeting Spalt-Like Transcription Factor 4

    Researchers performed dual luciferase assay, RNA immunoprecipitation assay and pull-down assay to confirm the interaction between miR-3622a-3p and spalt-like transcription factor 4 (SALL4). Western blot was carried out to determine the effects of miR-3622a-3p and SALL4 on stemness features and EMT.
    [Cell Death & Disease]

    Full Article

    Ciclopirox Activates PERK-Dependent Endoplasmic Reticulum Stress to Drive Cell Death in Colorectal Cancer

    Scientists report that ciclopirox exhibited strong antitumorigenic properties in colorectal cancer by inducing cell cycle arrest, repressing cell migration, and invasion by affecting N-cadherin, Snail, E-cadherin, MMP-2, and MMP-9 expression. Disruption of cellular bioenergetics contributed to ciclopirox-associated inhibition of cell growth, migration, and invasion.
    [Cell Death & Disease]

    Full Article

    Continuous Formation of Small Clusters with LGR5-Positive Cells Contributes to Tumor Growth in a Colorectal Cancer Xenograft Model

    Investigators evaluated the growth of moderate differentiated colorectal cancer from LGR5-positive cells, which was a cancer stem cell marker of colorectal cancer, using xenograft and three-dimensional culture models spatiotemporally.
    [Laboratory Investigation]

    Abstract

    The HIF Target ATG9A is Essential for Epithelial Barrier Function and Tight Junction Biogenesis

    Scientists found that lentiviral-mediated knockdown of ATG9A in intestinal epithelial cells prevented epithelial barrier formation by >95% and resulted in significant mislocalization of multiple tight junction proteins.
    [Molecular Biology of the Cell]

    Abstract

    Signatures of Co-Deregulated Genes and Their Transcriptional Regulators in Colorectal Cancer

    Researchers reanalyzed 19 GEO gene expression profiles to identify and annotate colorectal cancer versus normal signatures, single-gene perturbation, and single-drug perturbation signatures.
    [npj Systems Biology and Applications]

    Full Article

    Tools and products for your COVID-19 research.
    REVIEWS

    Src Family Tyrosine Kinases in Intestinal Homeostasis, Regeneration and Tumorigenesis

    The authors review recent findings on Src family kinase (SFK) signaling during intestinal homeostasis, regeneration and tumorigenesis. They also describe the key nongenetic mechanisms underlying SFK tumour activities in colorectal cancer, and discuss how these mechanisms could be exploited in therapeutic strategies to target SFK signaling in metastatic colon cancer.
    [Cancers]

    Full Article

    INDUSTRY AND POLICY NEWS

    ORTIKOS™, the First and Only Once-Daily Dose for Treatment of Mild to Moderate Crohn’s Disease, Now Available in the U.S

    Ferring Pharmaceuticals Inc. announced the launch of ORTIKOS™ in the United States, which was approved as the only once-daily treatment of mild to moderate active Crohn’s disease involving the ileum and/or the ascending colon, in patients eight years of age and older, and maintenance of clinical remission in adults involving the ileum and/or the ascending colon for up to three months.
    [Ferring Pharmaceuticals (Businesswire, Inc.)]

    Press Release

    Foreign Researchers Accused of Hiding Links to Chinese Military

    Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
    [The Scientist]

    Editorial

    FEATURED EVENT

    Keystone eSymposia | Advances in Cancer Immunotherapy

    August 17 – August 19
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    JOB OPPORTUNITIES

    Post Doctoral Fellow – Digestive Diseases

    Emory University – Atlanta, Georgia, United States

    Research Scientist – Colon and Rectal Surgery

    Wexner Medical Center – Columbus, Ohio, United States

    Research Scientist – In Vivo Research on Wnt Signaling in Self-Renewal

    Surrozen, Inc. – South San Francisco, California, United States

    Postdoctoral Fellow – Molecular Diagnostics and Experimental Therapeutics

    City of Hope – Monrovia, California, United States

    Postdoctoral Associate – Colorectal Cancer

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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