 | | Vol. 6.37 – 25 September, 2020 |
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| Researchers found that peptide YY was required in the small intestine to maintain normal electrophysiology in the presence of vasoactive intestinal polypeptide, a potent stimulator of ion secretion classically produced by enteric neurons.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated the role of protein tyrosine phosphatase receptor type F (PTPRF), a receptor-type tyrosine phosphatase, in regulating Wnt signaling in colorectal cancer. Knockdown of PTPRF decreased cell proliferation in patient-derived primary colon cancer cells and established colorectal cancer cell lines.
[Oncogene] |
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| The authors identified a novel dual-target inhibitor, APIO-EE-07, that could block both RSK1 and MSK2 kinase activity in a dose-dependent manner. APIO-EE-07 inhibited cell growth and induced apoptosis and also increased expression of Bax as well as cleaved caspase-3 and -PARP in colon cancer cells by downregulating RSK1 and MSK2 downstream targets, including CREB and ATF1.
[Oncogene] |
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| Investigators evaluated aspirin-mediated effects on phenotype and stem cell markers in intestinal organoids derived from mouse and human familial adenomatous polyposis patients. colorectal cancer cell lines were used to study effects on motility, invasion, Wnt signalling and epithelial-mesenchymal transition.
[Cellular and Molecular Gastroenterology and Hepatology] |
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| Researchers investigated the role of circFoxp1 in colon cancer and the regulatory mechanism between circFoxp1 and Foxp1. 78 human colon tumor tissues and the matched paracancerous tissues were collected. Quantitative polymerase chain reaction, immunohistochemistry, quantitative methylation-specific PCR, chromatin immunoprecipitation assay, CCK-8 assay, and Tumor xenograft in nude mice were performed.
[Cell Death & Disease] |
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| Scientists investigated the genotoxic and cytotoxic effects of heme iron versus inorganic iron in human colonic epithelial cells, human colorectal cancer cell lines and murine intestinal organoids.
[Cell Death & Disease] |
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| Stimulator of interferon genes(STING) promote intestinal epithelial cells REG3γ expression to inhibit enteric infection and intestinal inflammation, thus, maintaining the intestinal homeostasis.
[FASEB Journal] |
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| Researchers showed that Rab13 regulated the secretion of small extracellular vesicles (sEVs) corresponding to both traditional exosomes and a novel subset of vesicles containing both β1-integrin and Rab13. They found that exposure of recipient cells to sEVs from KRAS mutant donor cells increased proliferation and tumorigenesis and that knockdown of Rab13 blocked these effects.
[Scientific Reports] |
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| Berberine promotes the degradation of SHH mRNA in colorectal cancer cells, interrupting the paracrine Hedgehog signaling pathway activity thus suppresses the colorectal cancer growth.
[Acta Pharmacologica Sinica] |
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| Investigators showed that both normal crypts and tumors underwent metabolic remodeling in response to oxidative phosphorylation deficiency by upregulating the de novo serine synthesis pathway.
[Nature Cancer] |
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| The authors discuss the host–microbiota interactions in colorectal cancer that have been reported so far, with particular focus on mechanisms that are linked to intestinal barrier disruption, genotoxicity and deleterious inflammation.
[Nature] |
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| New approaches such as single-cell transcriptomics and the use of organoid models have led to the identification of the signals that guide fate specification of stem cell progeny into the six intestinal cell lineages.
[Nature Reviews Molecular Cell Biology] |
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| Boehringer Ingelheim and Mirati Therapeutics, Inc. announced a clinical collaboration to evaluate the combination of BI 1701963, a SOS1::pan-KRAS inhibitor blocking KRAS independent of mutation type, and MRTX849, a KRAS G12C selective inhibitor in patients with solid tumors that harbor the KRAS G12C mutation.
[Mirati Therapeutics, Inc.] |
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| October 13 – October 14
Virtual |
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| | City of Hope – Monrovia, California, United States |
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| | Chr. Hansen A/S – Hørsholm, Denmark |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | The University of Arizona – Tucson, Arizona, United States |
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| | Emory University – Atlanta, Georgia, United States |
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