 | | Vol. 6.40 – 16 October, 2020 |
| |
|
|
| Researchers showed that volumetric compression regulated the growth of intestinal organoids by modifying intracellular crowding and elevating Wnt/β-catenin signaling.
[Cell Stem Cell] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists report that NAD-dependent deacetylase sirtuin-1 (SIRT1) signaling regulated colorectal cancer (CRC) stemness by enhancing expression of CD24, a CRC stemness promoter.
[Cancer Research] |
|
|
|
| Investigators evaluated alterations in the colon mucus layer in two, 16‐, and 24‐month‐old mice and aged humans. Aged colons showed defective intestinal mucosal barrier and changed mucus properties.
[Aging Cell] |
|
|
|
| Long non-coding RNA small nucleolar host gene 11 (SNHG11) post-transcriptionally upregulated catenin beta 1 and autophagy related 12 through miR-483-3p/miR-1276, while the processing of pre-miR-483/pre-miR-1276 was hindered by SNHG11. SNHG11 induced GSK-3β ubiquitination through interacting with Cullin 4A to further activate the Wnt/β-catenin pathway.
[Molecular Therapy] |
|
|
|
| Scientists established GC organoids (GCOs) and gradually treated them with higher concentrations of 5-FU. They successfully harvested four 5-FU-resistant GCOs, which were supported by significant changes in the expression of molecules related to 5-FU metabolism. Microarray analysis was peformed using three normal gastric organoids and three pairs of 5-FU-resistant and parental GCOs.
[Oncogene] |
|
|
|
| Gain‐and loss‐of function assays revealed that LINC01578 enhanced colon cancer cell viability and mobility in vitro and colon cancer liver metastasis in vivo. Mechanistically, NF‐κB and YY1 directly bound to the LINC01578 promoter, enhanced its activity, and activated LINC01578 expression.
[Molecular Oncology] |
|
|
|
| cir-ITCH was shown to prevent gastric cancer tumourgenesis through the Wnt/β-catenin signalling pathway by sequestering miR-17.
[Scientific Reports] |
|
|
|
| The solid lipid nanoparticle(SLN)-loaded 5-FU was developed by utilizing a Strategic and unique Method to Advance and Refine the Treatment of colorectal cancer through hot and cold homogenization approach. The SLN was made of unique PEGylated lipids and combination of the surfactants.
[Scientific Reports] |
|
|
|
| Artificial modulation of BATF3 was conducted to measure the malignant phenotypes of colorectal cancerc cells, while tumor-bearing mice were examined to determine the in vivo effects.
[Cancer Gene Therapy] |
|
|
|
| Luciferase reporter assays results showed that miR-93-5p was a direct target of CA3-AS1 in SGC-7901 and BCG-823. BTG3 was identified as a direct target gene of miR-93-5p. Restore experiments showed that CA3-AS1 upregulated the expression level of BTG3 and inhibited the gastric cancer cells invasion by sponging miR-93-5p.
[Gene Therapy] |
|
|
|
|
| The authors review insights from mice and other vertebrate models into the transcriptional regulatory mechanisms underlying intestinal epithelial identity and microbial responsiveness, including DNA methylation, chromatin accessibility, histone modifications and transcription factors.
[Nature Reviews Gastroenterology & Hepatology] |
|
|
|
|
| Targovax ASA announced that the colorectal cancer cohort in part 1 of the ONCOS-102 and durvalumab trial in colorectal and platinum-resistant ovarian cancer that has spread to the peritoneum has met the pre-defined efficacy threshold of patients without progression at the end of week 24. The second part of the colorectal expansion cohort is now open for recruitment.
[Tragovax] |
|
|
|
|
| November 11 – November 13
Virtual |
|
|
|
|
|
| | University of Minnesota – Minneapolis, Minnesota, United States |
|
|
|
| | Lerner Research Institute – Cleveland, Ohio, United States |
|
|
|
| | Moffitt Cancer Center – Tempa, Florida, United States |
|
|
|
| | Baylor College of Medicine – Houston, Texas, United States |
| |
|
|
| City of Hope – Monrovia, California, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
