Intestinal Cell News Volume 6.44 | Nov 13 2020

May 12, 2022

2020-13-11 | ICN 6.44

Intestinal Cell News by STEMCELL Technologies

Vol. 6.44 – 13 November, 2020

TOP STORY

IRF3
Prevents Colorectal Tumorigenesis via Inhibiting the Nuclear Translocation of β-Catenin

Genetic ablation of IRF3 profoundly promoted the proliferation of intestinal epithelial cells via aberrantly activating Wnt signaling.
[Nature Communications]

Full Article

Immunofluorescence image of adult stem cell-derived intestinal organoids.

PUBLICATIONSRanked by the impact factor of the journal

HMGB1
Released from GSDME-Mediated Pyroptotic Epithelial Cells Participates in the Tumorigenesis of Colitis-Associated Colorectal Cancer through the ERK1/2 Pathway

In vitro experiments demonstrated that high-mobility group box protein 1 (HMGB1) induced proliferation and proliferating cell nuclear antigen expression in CT26 colon cancer cells through the ERK1/2 pathway.
[Journal of Hematology & Oncology]

Full Article

Loss
of Interleukin-17 Receptor D Promotes Chronic Inflammation-Associated Tumorigenesis

Investigators showed that genetic disruption of interleukin-17 receptor D (Il17rd) led to the increased formation of spontaneous tumors in multiple tissues of aging mice. Loss of IL-17RD also promoted tumor development in a model of colitis-associated colorectal cancer, associated with an exacerbated inflammatory response.
[Oncogene]

Abstract

Synthetic
Lethality between MyD88 Loss and Mutations in Wnt/β-Catenin Pathway in Intestinal Tumor Epithelial Cells

The authors clarified the mechanisms by which epithelial MyD88 contributes to intestinal tumor formation and addressed whether MyD88 can be a therapeutic target of colorectal cancer.
[Oncogene]

Abstract

Exosomal
miR-590-3p Derived from Cancer-Associated Fibroblasts Confers Radioresistance in Colorectal Cancer

High expression of miR-590-3p and low expression of CLCA4 was found in both colorectal cancer (CRC) tissues and cell lines. CLCA4 was indicated as a target gene of miR-590-3p. CAF-derived exosomes were extracted and co-cultured with CRC cells which were then exposed to radiation.
[Molecular Therapy-Nucleic Acids]

Abstract Graphical Abstract

LncRNA
NEAT1 Remodels Chromatin to Promote the 5-Fu Resistance by Maintaining Colorectal Cancer Stemness

The authors observed that lncRNA NEAT1 was associated with 5-fluorouracil (5-Fu) resistance in colorectal cancer. They showed that NEAT1 promoted 5-Fu resistance in colorectal cells.
[Cell Death & Disease]

Full Article

SHP2
Regulates the Development of Intestinal Epithelium by Modifying OSTERIX⁺ Crypt Stem Cell Self‐Renewal and Proliferation

OSTERIX, an OB‐specific zinc finger‐containing transcription factor was for the first time found to be expressed in gastrointestinal crypt cells, and SHP2 expression in the crypt Osx⁺ cells was critical for self‐renewal and proliferation.
[FASEB Journal]

Full Article

Mesenchymal
Stroma/Stem‐Like Cells of GARP Knockdown Inhibits Cell Proliferation and Invasion of Mouse Colon Cancer Cells (MC38) through Exosomes

The authors explored the therapy role of mesenchymal stroma/stem‐like cell‐derived exosomes targeting glycoprotein A repetition predominant (GARP) in mouse colon cancer cell MC38.
[Journal of Cellular and Molecular Medicine]

Full Article

Increase
in Epithelial Permeability and Cell Metabolism by High Mobility Group Box 1, Inflammatory Cytokines and TPEN in Caco-2 Cells as a Novel Model of Inflammatory Bowel Disease

Caco-2 cells in 2D culture and 2.5D Matrigel culture were pretreated with transforming growth factor-β type 1 receptor kinase inhibitor EW-7197, epidermal growth factor receptor kinase inhibitor AG-1478 and a TNFα antibody before treatment with HMGB1 and inflammatory cytokines.
[International Journal of Molecular Sciences]

Full Article

In Vivo
Transplantation of Human Intestinal Organoids Enhances Select Tight Junction Gene Expression

Researchers define intestinal epithelial barrier function in human intestinal organoid-derived tissue-engineered small intestine.
[Journal of Surgical Research]

Abstract

Request your free copy of the 'Growing Organoids from Stem Cells' Wallchart

REVIEWS

The Roles and Functions of Paneth Cells in Crohn’s Disease: A Critical Review

Paneth cells are located at the base of small intestinal crypts and secrete the α‐defensins, human α‐defensin 5 and human α‐defensin 6 in response to bacterial, cholinergic and other stimuli.
[Cell Proliferation]

Full Article

Myosin
Light Chain Kinase Regulates Intestinal Permeability of Mucosal Homeostasis in Crohn’s Disease

Researchers investigated the potential role of intestinal permeability in Crohn’s disease pathogenesis. Intestinal permeability is usually mediated by cytoskeleton and intercellular junctions.
[Expert Review of Clinical Immunology]

Abstract

INDUSTRY AND POLICY NEWS

Progenity
Announces Encouraging Preclinical Data Supporting the Potential of the Company’s Oral Drug Delivery System in Targeting the Colon

Progenity, Inc. announced positive preliminary preclinical data regarding the performance of its oral drug delivery system (DDS). The DDS capsule uses a proprietary autonomous localization technology designed to identify the ileal/ileocecal region of the GI tract.
[Progenity, Inc.]

Press Release

FEATURED EVENT

IRF3
Prevents Colorectal Tumorigenesis via Inhibiting the Nuclear Translocation of β-Catenin

HMGB1
Released from GSDME-Mediated Pyroptotic Epithelial Cells Participates in the Tumorigenesis of Colitis-Associated Colorectal Cancer through the ERK1/2 Pathway

Loss
of Interleukin-17 Receptor D Promotes Chronic Inflammation-Associated Tumorigenesis

Synthetic
Lethality between MyD88 Loss and Mutations in Wnt/β-Catenin Pathway in Intestinal Tumor Epithelial Cells

Exosomal
miR-590-3p Derived from Cancer-Associated Fibroblasts Confers Radioresistance in Colorectal Cancer

LncRNA
NEAT1 Remodels Chromatin to Promote the 5-Fu Resistance by Maintaining Colorectal Cancer Stemness

SHP2
Regulates the Development of Intestinal Epithelium by Modifying OSTERIX⁺ Crypt Stem Cell Self‐Renewal and Proliferation

Mesenchymal
Stroma/Stem‐Like Cells of GARP Knockdown Inhibits Cell Proliferation and Invasion of Mouse Colon Cancer Cells (MC38) through Exosomes

Increase
in Epithelial Permeability and Cell Metabolism by High Mobility Group Box 1, Inflammatory Cytokines and TPEN in Caco-2 Cells as a Novel Model of Inflammatory Bowel Disease

In Vivo
Transplantation of Human Intestinal Organoids Enhances Select Tight Junction Gene Expression

The Roles and Functions of Paneth Cells in Crohn’s Disease: A Critical Review

Myosin
Light Chain Kinase Regulates Intestinal Permeability of Mucosal Homeostasis in Crohn’s Disease

Progenity
Announces Encouraging Preclinical Data Supporting the Potential of the Company’s Oral Drug Delivery System in Targeting the Colon

Stem Cells and Cancer

> See All Events

Associate
Program Director – Inflammatory Bowel Disease

Postdoctoral
Fellow – Breast and Colorectal Cancer

Postdoctoral Research Associate – Colorectal Cancer

Senior
Research Technologist – Inflammation and Immunity

Research Associate – Ex
Vivo and In Vivo Models of Colorectal Cancer

> See All Jobs