Intestinal Cell News Volume 7.12 | Apr 9 2021

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    Justin.choi
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    2021-04-09 | ICN 7.12


    Intestinal Cell News by STEMCELL Technologies
    Vol. 7.12 – 9 April, 2021
    TOP STORY

    Loss of ARID1A Activates mTOR Signaling and SOX9 in Gastric Adenocarcinoma-Rationale for Targeting ARID1A Deficiency

    Genomic alterations in AT-rich interactive domain 1A (ARID1A) were analyzed in gastric adenocarcinoma. Mouse gastric epithelial cells from CK19-Cre-Arid1Afl/fl and wild-type mice were used to determine the activation of oncogenic genes due to loss of Arid1A.
    [Gut]

    Abstract
    Explore scientific events this April with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    Mutant KRAS Triggers Functional Reprogramming of Tumor-Associated Macrophages in Colorectal Cancer

    Mutationally activated KRAS in tumor cells reprograms macrophages to a tumor-associated macrophage-like phenotype via a combination effect of tumor-derived CSF2 and lactate.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Processed Foods Drive Intestinal Barrier Permeability and Microvascular Diseases

    Investigators showed in rodent models that long-term consumption of a processed diet drives intestinal barrier permeability and an increased risk of chronic kidney disease.
    [Science Advances]

    Full ArticlePress Release

    Symbiotic Polyamine Metabolism Regulates Epithelial Proliferation and Macrophage Differentiation in the Colon

    Scientists showed that microbial polyamines reinforce colonic epithelial proliferation and regulate macrophage differentiation.
    [Nature Communications]

    Full Article

    Long Noncoding RNA (lncRNA) EIF3J-DT Induces Chemoresistance of Gastric Cancer via Autophagy Activation

    In vitro and in vivo experiments showed that EIF3J-DT activated autophagy and induced drug resistance in gastric cancer cells by targeting ATG14.
    [Autophagy]

    Abstract

    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS-STING Activation and Chemotherapeutic Sensitivity in Colon Cancer

    The authors investigated the effect of Src homology-2 domain-containing protein tyrosine phosphatase-2 on tumor cell-intrinsic STING pathway activity and DNA repair in colon cancer.
    [Cancer Research]

    Abstract

    USP42 Protects ZNRF3/RNF43 from R-Spondin-Dependent Clearance and Inhibits Wnt Signaling

    Researchers showed that the USP42 antagonized R‐spondin by protecting ZNRF3/RNF43 from ubiquitin‐dependent clearance.
    [EMBO Reports]

    Full Article

    HomeoboxC6 Promotes Metastasis by Orchestrating the DKK1/Wnt/β-Catenin Axis in Right-Sided Colon Cancer

    Homeobox C6 was validated to be overexpressed in right-sided colon cancer and associated with poor prognosis.
    [Cell Death & Disease]

    Full Article

    Utidelone Inhibits Growth of Colorectal Cancer Cells through ROS/JNK Signaling Pathway

    Utidelone (UTD1) dramatically inhibited colorectal cancer cell proliferation in vitro. Immunofluorescence staining showed that UTD1 induced the formation of microtubule bundling and asters in RKO cells.
    [Cell Death & Disease]

    Full Article

    Intestinal-Epithelial LSD1 Controls Goblet Cell Maturation and Effector Responses Required for Gut Immunity to Bacterial and Helminth Infection

    Scientists discovered that LSD1 was important for goblet cell maturation and goblet-cell effector molecules such as RELMß.
    [PLoS Pathogens]

    Full Article

    Schlafen 11 Predicts Response to Platinum-Based Chemotherapy in Gastric Cancers

    Researchers investigated the potential clinical utility of SLFN11 in the treatment of gastric cancer (GC). In GC cells and organoids, long-term treatment with oxaliplatin suppressed SLFN11 expression while imparting drug resistance.
    [British Journal of Cancer]

    Abstract

    The Murine Intestinal Stem Cells Are Highly Sensitive to the Modulation of the T3/TRα1-Dependent Pathway

    By using ex vivo 3D organoid cultures and molecular approaches scientists observed early responses to T3 involving the T3-metabolizing enzyme Dio1 and the transporter Mct10, accompanied by a complex response of stem cell- and progenitor-enriched genes.
    [Development]

    Abstract

    Suppression of Elevated Cdc42 Activity Promotes the Regenerative Potential of Aged Intestinal Stem Cells

    Elevation of Cdc42 activity in young animals by genetic means causes premature ISC aging, whereas pharmacological suppression of elevated Cdc42 activity restores organoid formation potential in vitro.
    [iScience]

    AbstractGraphical Abstract
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    REVIEWS

    Epithelial Sensing of Microbiota-Derived Signals

    The authors highlight the pathways by which intestinal epithelial cells sense microbiota-derived signals and the necessity of these detection pathways in maintaining epithelial barrier integrity.
    [Genes & Immunity]

    Abstract
    INDUSTRY AND POLICY NEWS

    DESTINY-CRC02 Phase II Trial of ENHERTU® Initiated in Patients with HER2 Overexpressing Advanced Colorectal Cancer

    Daiichi Sankyo Company, Limited AstraZeneca announced that the first patient was dosed in DESTINY-CRC02, a global Phase II trial evaluating the efficacy and safety of ENHERTU® in patients with HER2 overexpressing locally advanced, unresectable or metastatic colorectal cancer with progression following treatment with standard of care chemotherapy.
    [Daiichi Sankyo Company]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells and Regenerative Medicine

    January 12 – 14, 2022
    Shanghai, China

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Intestinal Stem Cell Genetics

    Emory University – Atlanta, Georgia, United States

    Research Associate / PhD student – Human Gastrointestinal Organoids

    Technische Universität Dresden – Dresden, Germany

    Medicinal Chemist – Muscle-Wasting, Neurodegeneration, and Oncology

    Almac – Belfast, Ireland

    Postdoctoral Fellow – Colonic Epithelium

    Weill Cornell Medicine – New York, New York, United States

    Senior Bioinformatician – Intestinal Microbiota

    Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom

    > See All Jobs

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