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| Researchers uncovered a previously unrecognized crosstalk between adult intestinal stem cells in Drosophila and the vasculature-like tracheal system, which was essential for intestinal regeneration.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that the adult intestinal tracheae were dynamic and responded to enteric infection, oxidative agents and tumors with increased terminal branching.
[Nature Cell Biology] |
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| The authors reported that after distinct types of intestinal epithelial damage, IL-1R1 signaling in GREM1+ mesenchymal cells increased production of R-spondin 3, a Wnt agonist required for intestinal stem cell self-renewal.
[Science Immunology] |
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| Researchers used IFN receptor-deficient mice in a dextran sulfate sodium model of acute intestinal injury to study the contributions of type I and III interferons to the initiation, progression and resolution of acute colitis.
[Nature Communications] |
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| Investigators showed that Nur77 enhanced TGFβ/Smad3-induced inhibitor of differentiation 1 (ID1) mRNA expression through hindering Smurf2-mediated Smad3 mono-ubiquitylation, resulting in ID1 upregulation.
[Nature Communications] |
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| The authors determined the role of LPA receptor 5 (LPA5) in regulation of intestinal epithelial barrier. Human colonic epithelial cell lines were used to determine the LPA5-mediated signaling pathways that regulate epithelial barrier.
[Cellular and Molecular Gastroenterology and Hepatology] |
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| Scientists identified serine hydroxymethyltransferase-2 (SHMT2) as a critical regulator of 5-FU chemoresistance in colorectal cancer.
[Oncogene] |
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| Researchers identified that Bacteroides fragilis toxin (BFT) signals through GPR35. Blocking GPR35 function in colon epithelial cells (CEC) using the GPR35 antagonist ML145, in conjunction with shRNA knock-down and CRISPRcas-mediated knock-out, resulted in reduced CEC-response to BFT.
[Communications Biology] |
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| Using a novel screening method, investigators identified novel transcription factors that regulated the intestinal stem cell fate upon endoplasmic reticulum stress.
[Scientific Reports] |
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| The authors investigated the effects of indigo on wound closure in colon epithelial cells. Oral administration of indigo induced expression of Cytochrome P450 1A1 in the colon but not in the liver, suggesting that indigo stimulated AhR from the luminal side of the colon.
[Journal of Natural Medicines] |
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| Scientists review the current knowledge on mucosal intestinal bacterial immune recognition focusing on TH17 responses and identify commonalities between intestinal pathobiont and vaccine-induced TH17 responses.
[Genes & Immunity] |
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| Merck announced that the FDA has approved KEYTRUDA, Merck’s anti-PD-1 therapy, in combination with trastuzumab, fluoropyrimidine- and platinum-containing chemotherapy, for the first-line treatment of patients with locally advanced unresectable or metastatic HER2-positive gastric or gastroesophageal junction adenocarcinoma.
[Merck (BusinessWire, Inc)] |
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| May 31 – June 2, 2021
Virtual |
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| | BioMed X Institute – Heidelberg, Germany |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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