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| Researchers performed comprehensive CRISPR screens to interrogate the regulatory network of Wnt/β-catenin signaling in colorectal cancer cells.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Gut-on-a-chip microfluidics technology presents an opportunity to characterize strain function within a simulated human gastrointestinal tract. The authors showed how in vitro gut-chip models could be used to construct mechanistic models of strain activity and recapitulate the behavior of the engineered strain in a non-human primate model.
[Nature Communications] |
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| B. dentium cell-free supernatant and γ-glutamylcysteine were taken up by human colonic T84 cells, increased glutathione levels, and reduced ROS generated by the endoplasmic reticulum (ER)-stressors thapsigargin and tunicamycin.
[Gut Microbes] |
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| Scientists used a human intestinal organoid model to define host transcriptional responses to S. Typhimurium infection, also determining host pathways dependent on Salmonella pathogenicity island- 1-(SPI-1) and -2-encoded type 3 secretion systems
[mBio] |
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| Intestinal organoids derived from mouse small intestine were treated with vitamin D3, and the effects on intestinal stemness and differentiation were evaluated using real-time PCR and immunofluorescence staining of the distinct lineage markers.
[Stem Cell Research & Therapy] |
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| RNA-sequencing datasets in the NCBI GEO repository were first analyzed; upregulation of cannabinoid receptors was observed in both primary and metastatic colorectal cancer tumor tissues.
[Cancer Gene Therapy] |
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| Investigators identified the mechanism of long non-coding RNA OIP5-AS1 (lncRNA OIP5-AS1) in colon cancer (CC) development. OIP5-AS1 expression pattern in CC tissues and cells was detected and the relation between OIP5-AS1 level and CC prognosis was analyzed.
[Cancer Gene Therapy] |
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| The effects of worenine on colorectal cancer cell proliferation, colony formation and cell cycle distribution were measured.
[Cellular & Molecular Biology Letters] |
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| Researchers determined how glucose concentration influences cancer cells’ response to metformin. They used two colorectal cancer cell lines with different growth rates and clinically achievable metformin concentrations.
[Scientific Reports] |
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| Investigators examined the potential of exosomal miRNAs extracted from colorectal adenoma (CRA) organoids as biomarkers in the clinical liquid biopsy CRA test.
[Clinical and Translational Gastroenterology] |
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| Scientists focus on the complicated communication between the mucus barrier and gut microbiome to explore a promising new avenue for ulcerative colitis therapy.
[Experimental & Molecular Medicine] |
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| The 2021 Pershing Square Sohn Prize for Young Investigators in Cancer Research has been awarded to Christine Iok In Chio, PhD, and Xuebing Wu, PhD, for their out-of-the box approaches to cancer research.
[Columbia University] |
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| June 21 – 24, 2021
Virtual |
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| | Louisiana State University – New Orleans, Louisiana, United States |
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| | BioMed X Institute – Heidelberg, Germany |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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