 | | Vol. 7.26 – 16 July, 2021 |
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| Via binding to CD147, TFF3 enhanced CD147-CD44s interaction, resulting in signal transducer and activator of transcription 3 activation and prostaglandin G/H synthase 2 expression, which were indispensable for TFF3-induced colorectal cancer migration, proliferation, and invasion.
[Signal Transduction and Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators used machine-learning to pinpoint a path of continuum states which most effectively predicted disease outcome and was enriched in gene clusters that maintained the integrity of the gut epithelial barrier. Potential for treatment efficacy was confirmed in patient-derived organoids.
[Nature Communications] |
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| Knockdown of CDK15 suppressed cell proliferation and anchorage-independent growth of colorectal cancer cells and inhibited tumor growth in cell line-derived xenograft model.
[Cell Death & Differentiation] |
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| In murine intestinal epithelium with telomere dysfunction, DNA damage-induced activation of ataxia-telangiectasia mutated (ATM) resulted in ATM-mediated phosphorylation and activation of the YAP1 transcriptional coactivator, which in turn up-regulated pro-IL-18, a pivotal immune regulator in IBD pathogenesis.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| CRIP1 downregulation caused homologous recombination repair deficiency with concomitant increase in cell sensitivity to cisplatin, epirubicin, and the poly ADP-ribose polymerase inhibitor olaparib in gastric cancer cells.
[Oncogene] |
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| Colorectal cancer cells hijacked prostaglandin E2 (PGE2) to non-canonically promote Hedgehog transcriptional factor Gli activity and Gli-dependent proliferation of colorectal cancer cells in a Smo-independent manner.
[Cell Death & Disease] |
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| Diosmetin administration significantly decreased disease activity index score and ameliorated microscopic colon tissue damage, increased the expression of tight junction proteins, and reduced the secretion of proinflammatory cytokines IL-1β, IL-6, TNF-α, and Cox-2 in colon tissue.
[Acta Pharmacologica Sinica] |
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| The authors conducted a computational analysis using Ingenuity Pathway Analysis to identify multiple activated signaling networks in colorectal cancer (CRC), while functional annotation highlighted activation of cell proliferation and migration as the hallmark of CRC.
[Scientific Reports] |
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| Researchers determined the expression and localization of Parkinson’s disease 7 in the colon biopsies of children with IBD, in the colon of dextran sodium sulphate treated mice, and in HT-29 colonic epithelial cells.
[Scientific Reports] |
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| Direct exposure of colonic epithelial organoids to dextran sulfate sodium, oxazolone, or TNBS resulted in increased apoptosis and loss of Lgr5+ cells. Targeted ablation of Lgr5+ cells resulted in severe exacerbation of chronic, antibody-induced IL-10-deficient colitis, but had only modest effects in TNBS-induced colitis.
[American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| The potential functions of long intergenic non-protein coding RNA 1287 (LINC01287) were evaluated by cell viability assay, colony formation assay, soft agar assay, flow cytometry, transwell migration and invasion assay, and tumor xenograft growth in colon cancer cells.
[BMC Cancer] |
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| Scientists studied the mechanism of miR-122 in regulating intestinal barrier function in acute pancreatitis (AP). AP rat model was constructed via intraperitoneal injection of ketamine, and primary intestinal epithelial cells were isolated from rats for in vitro studies.
[Biochemical Genetics] |
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| Recent advances have investigated the ecological and evolutionary processes which transform normal cells into cancer. The authors describe the role which driver mutations play in the Vogelstein model and subsequently demonstrate the evidence which supports a more complex model.
[Oncogenesis] |
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| Varying amounts of undigested or partially digested proteins reach the colon where they are metabolized by the microbiota, resulting in the formation of various compounds. In humans, their accumulation is potentially harmful, and it has been proposed that they could be involved in the development of pathologies such as colorectal cancer and ulcerative colitis.
[Amino Acids] |
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| Auris Medical Holding Ltd. announced the selection of mutant KRAS-driven colorectal cancer as the first therapeutic indication for its OligoPhoreâ„¢ oligonucleotide delivery platform, based on outcomes from studies with OligoPhoreâ„¢ enabled KRAS silencing, and a well-defined regulatory and development pathway.
[Auris Medical Holding Ltd.] |
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| Galapagos NV reported topline results with GLPG3970 in three patient studies. Phase IIa randomized 31 biologic-naïve patients with moderate to severely active ulcerative colitis in a two to one ratio, GLPG3970 to placebo.
[Galapagos NV (Globe Newswire, Inc.)] |
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| November 15 – 19, 2021
Virtual |
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| | Tübingen University – Tuebingen, Germany |
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| | Research Center for Molecular Medicine – Vienna, Austria |
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| | The Hebrew University of Jerusalem – Jerusalem, Israel |
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| | University of Maryland, College Park – College Park, Maryland, United States |
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| | GSK – Moon Township, Pennsylvania, United States |
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