 | | Vol. 7.28 – 30 July, 2021 |
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| The multifunctional capability of a proposed nanosystem was demonstrated by investigating the efficient Galunisertib delivery, the enhanced epithelial-to-mesenchymal transition reversion in colorectal cancer cells, and the intracellular quantification of drug release with a sub-femtogram resolution by surface-enhanced Raman spectroscopy (SERS).
[Small] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Circular RNA stabilizing HOXC10 (cis-HOX) was robustly expressed in colorectal tumor-initiating cells (TICs). cis-HOX knockout decreased colorectal TIC numbers and impaired the self-renewal, tumorigenesis, and metastatic capacities of TICs, whereas cis-HOX overexpression drove colorectal TIC self-renewal and metastasis.
[Cell Reports] |
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| B-Myb overexpression accelerated cell proliferation, cell cycle progression and cell motility in colorectal cancer cells, and promoted tumor growth in orthotopic nude mouse models in vivo.
[Oncogene] |
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| Scientists showed that activating transcription factor 3 (ATF3) was induced early during paligenosis in multiple cellular contexts, transcriptionally activating the lysosomal trafficking gene Rab7b. ATF3 and RAB7B were upregulated in gastric and pancreatic digestive-enzyme-secreting cells at the onset of paligenosis Stage 1.
[EMBO Reports] |
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| Researchers showed that VprBP was overexpressed in colon cancer and directly contributed to epigenetic gene silencing and cancer pathogenesis. Mechanistically, VprBP was mediated through H2AT120 phosphorylation-driven transcriptional repression of growth regulatory genes, resulting in a significantly higher proliferative capacity of colon cancer cells.
[Molecular Oncology] |
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| The possible use of an emerging functional food, the coconut haustorium, was evaluated against sodium fluoride-induced toxicity in intestinal cells. The cells exposed to fluoride showed significant cell death mediated through the increased lipid peroxidation and glutathione depletion.
[Environmental Research] |
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| Investigators demonstrated that the PARP inhibitor 123I-MAPi was a viable agent for the systemic administration and treatment of p53 mutant cancers. p53+/+ and p53–/– human colorectal cancer cell lines were evaluated for the ability of 123I-MAPi to induce tumor growth delay.
[Molecular Pharmaceutics] |
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| The authors evaluated the proapoptotic and antifibrotic efficacy of several classes of BH-3 mimetics in two in vitro fibrogenesis models. The candidate molecule, ABT-263, was advanced to a 3D human intestinal organoid model.
[Inflammatory Bowel Diseases] |
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| CircN4BP2L2 expression was increased in colorectal cancer tissues and cell lines, and its inhibition effectively inhibited proliferation, migration, and invasion of LoVo cells, and inhibited tumor growth and metastasis in vivo, whereas the forced expression of circN4BP2L2 facilitated the proliferation, migration, and invasion of HT-29 cells.
[Laboratory Investigation] |
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| Scientists showed that Btnl2 suppressed homeostatic proliferation of γδ intraepithelial lymphocytes preferentially in the ileum. During DSS-induced colitis, Btnl2-knockout mice exhibited increased inflammation and delayed mucosal repair in the colon.
[Communications Biology] |
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| Investigators analyzed the role of dietary salt in TNBS chronic colitis induced in rat, an intestinal fibrosis model, and in human colon fibroblast cells and showed that high-salt diet exacerbated undernutrition and promoted extracellular matrix-associated proteins in fibroblasts.
[Scientific Reports] |
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| The authors evaluate the mechanistic underpinnings of murine models of Crohn’s disease-ileitis, discuss their phenotypic similarities to human disease, and envisage their further exploitation for the development of novel targeted and personalized therapeutics.
[Mucosal Immunology] |
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| HUTCHMED Limited and AstraZeneca PLC have initiated a Phase II study of ORPATHYS®, an oral, potent, and highly selective small-molecule inhibitor of MET, a receptor tyrosine kinase, in patients with advanced or metastatic MET amplified gastric cancer or adenocarcinoma of the gastroesophageal junction.
[HUTCHMED Limited] |
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| Palisade Bio, Inc. and co-development partner Newsoara announced positive topline Phase II clinical trial data that LB1148 had a statistically significant effect in accelerating the return of bowel function in patients undergoing elective bowel resection surgery.
[Palisade Bio, Inc.] |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | Weill Cornell Medicine – New York, New York, United States |
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| | Tübingen University – Tuebingen, Germany |
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| | The Hebrew University of Jerusalem – Jerusalem, Israel |
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Cancer Stem Cell News
Cell Therapy News
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Intestinal Cell News
Mammary Cell News
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