 | | | Vol. 7.30 – 13 August, 2021 |
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| The biological role and mechanism of enterotoxigenic Bacteroides fragilis-mediated miR-149-3p in colitis and colon carcinogenesis were determined both in vitro and in vivo.
[Gastroenterology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists generated conditional, inducible knock-out mice for Rpap3 to inactivate the HSP90 component of R2TP in the intestinal epithelium. Proliferative stem cells and progenitors deficient for Rpap3 failed to import RNA polymerase II into the nucleus and they induced p53, cell cycle arrest and apoptosis.
[Nature Communications] |
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| Researchers provided detailed protocols for characterizing the coculture with regard to bacterial and organoid cell viability and growth kinetics and discussed considerations for assessing the impact of bacteria on gene expression and mutations through RNA and DNA sequencing.
[Nature Protocols] |
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| Investigators identified the microbiota-determined output of the pro-inflammatory metabolite, succinate, and elucidated the pathways that controlled transepithelial succinate absorption and subsequent succinate delivery to macrophages.
[Cell Reports] |
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| The authors observed that human colorectal cancers exhibited increased m6A mRNA methylation mediated by dysregulation of m6A erasers and readers. By performing methylated RNA-immunoprecipitation sequencing and transcriptomic sequencing, they identified DEGS2 as a downstream target of m6A dysregulation.
[Oncogene] |
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| Researchers found that NDRG1 enhanced the sensitivity of cetuximab in colorectal cancer cell lines by inhibiting the expression of epidermal growth factor receptor (EGFR); blocking EGFR phosphorylation and reducing the EGFR distribution in the cell membrane, cytoplasm and nucleus.
[Oncogene] |
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| Expression of GATA-binding factor 6 (GATA6), a transcription factor involved in intestinal epithelial cell differentiation, was evaluated in colon samples taken from healthy controls and IBD patients by real-time PCR and immunohistochemistry.
[Journal of Crohn’s and Colitis] |
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| RSL1D1 distributed throughout the nucleus in human colorectal cancer cells. Silencing of RSL1D1 gene induced cell cycle arrest at G1/S and cell apoptosis in a p53-dependent manner.
[Journal of Experimental & Clinical Cancer Research] |
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| Global lipidomics and RNA sequencing data showed that, in the tumor tissues of colorectal cancer-bearing mouse models, high-fat diet (HFD) not only increased tumor weight, but also the palmitic acid level and TLR4 expression, which were reduced when HFD was replaced by control diet.
[Cell Death & Disease] |
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| In colon cancer patient tissues, DNA damage sensitive miRs negatively correlated with BRCA1 levels, were associated with decreased probability of survival and thereby could be used as a prognostic biomarker.
[Journal of Cell Science] |
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| Scientists investigated the effect of tryptophan on cell migration and its underlying mechanism in porcine intestinal epithelial cells and showed that tryptophan could modulate IPEC-J2 cell proliferation and enhance cell migration.
[Food & Function] |
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| Investigators explored the relationship bewteen ursodeoxycholic acid (UDCA) and YAP in colorectal cancer (CRC) and found that the restoration of YAP expression alleviated the inhibitory effect of UDCA on CRC cell proliferation.
[Cell Death Discovery] |
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| Researchers examined enteric neural stem cells integration using an adapted ex vivo organotypic culture system. Significant remodeling of the intestinal extracellular matrix and musculature occurred upon transplantation, to facilitate donor cell integration within endogenous enteric ganglia.
[Scientific Reports] |
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| The authors summarize recent advances in the epigenetic, genetic, and functional integrity of the IFNγ signaling pathway in the colorectal cancer microenvironment and its immunological relevance in the therapeutic efficacy of and resistance to immune checkpoint blockade.
[Cellular & Molecular Immunology] |
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| Scientists present the current literature regarding the clinical presentation, diagnostic criteria, and management of eosinophilic gastritis/gastroenteritis.
[Current Gastroenterology Reports] |
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| Second Genome announced that they are entering a strategic collaboration with Arena Pharmaceuticals, Inc. to identify microbiome biomarkers associated with clinical response for their lead program in gastroenterology, etrasimod.
[Second Genome] |
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| October 14, 2021
Wädenswil, Switzerland |
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| | National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | The Scripps Research Institute – La Jolla, California, United States |
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| | Philipps University of Marburg – Marburg, Germany |
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| | Amgen – San Francisco, California, United States |
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| | Harvard Medical School​ – Boston, Massachusetts, United States |
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