 | | Vol. 7.37 – 1 October, 2021 |
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| The authors showed that SATB2, a colon-restricted chromatin factor, singularly preserved LGR5+ adult colonic stem cell and epithelial identity in mice and humans.
[Cell Stem Cell] |
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|  | | PUBLICATIONSRanked by the impact factor of the journal |
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| | The authors observed significant upregulation of lipocalin 2 expression in a newly established 5-fluorouracil-resistant colorectal cancer cell line.
[Oncogene] |
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| Scientists investigated the function of ASS1 in the gut epithelium during tissue regeneration and tumorigenesis, using intestinal epithelial conditional Ass1 knockout mice and organoids, and tissue specimens from colorectal cancer patients.
[Cell Death & Disease] |
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| Investigators explored the function and characterize the underlying mechanism of long noncoding RNA RNF144A-AS1 in gastric cancer metastasis and outgrowth.
[Cell & Bioscience] |
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| By modeling early stages of adenoma initiation researchers observed a reduced apoptotic rate in RAC1B overexpressing tumors, suggesting protection from apoptosis as a mediator of this phenotype.
[Cell Death & Disease] |
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| Sanguisorbae Radix extract (SRE) effectively inhibited the PD-1/PD-L1 interaction, thereby improving T cell receptor signaling and the NFAT-mediated luciferase activity of T cells. SRE treatment reduced tumor growth in the humanized PD-L1 MC38 cell allograft humanized PD-1 mouse model.
[Frontiers in Immunology] |
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| Researchers clarified the significance of autophagy in fibroblasts, focusing on the TP53 status in co-cultured human colorectal cancer cell lines in vitro.
[Scientific Reports] |
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| Gastric cancer (GC) is one of the most lethal malignant tumors. Researchers identified novel driver genes and clarified their roles in GC.
[Scientific Reports] |
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| Using a versatile platform for modulating neoantigen expression in colorectal cancer organoids and transplantation into the distal colon of mice, researchers showed that low expression precluded productive cross-priming and drove immediate T cell dysfunction.
[Nature Cancer] |
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| The authors consolidate knowledge on diet–microbiome interactions in local inflammation, gut microbiota imbalance and host immune dysregulation.
[Nature Reviews Gastroenterology & Hepatology] |
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| Bio-Thera Solutions, Ltd. and Intract Pharma announced a global collaboration and licensing agreement that gives Bio-Thera access to Intract’s Soteria® and Phloral® drug delivery technologies to develop novel oral monoclonal antibody treatments for chronic gastrointestinal inflammatory diseases.
[Bio-Thera Solutions, Ltd. (BusinessWire, Inc.)] |
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| Boehringer Ingelheim and OSE Immunotherapeutics SA announced that the first patient has been dosed in the expansion phase of the Phase I clinical trial evaluating BI 765063, a first-in-class monoclonal antibody antagonist of SIRPα, in combination with ezabenlimab, an anti-PD1 monoclonal antibody in patients with microsatellite stable advanced endometrium or colorectal cancer.
[Boehringer Ingelheim (GlobeNewswire, Inc.)] |
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| October 5 – 6, 2021
Virtual |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| The University of New Mexico – Albuquerque, New Mexico, United State |
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| Scripps Research Florida – Jupiter, Florida, United States |
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| Zhejiang University School of Medicine – Hangzhou, China |
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| | Purdue University – West Lafayette, Indiana, United States |
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