 | | Vol. 7.39 – 15 October, 2021 |
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| The authors investigated the profitable effect of carbon nanotubes (CNTs) with a different graphene layer and surface modification on the 3D model of intestinal organoids and demonstrated that CNTs promoted the development of intestinal organoids over time.
[ACS Nano] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Diets high in cholesterol alter intestinal immunity. Scientists examined how the cholesterol metabolite 25-hydroxycholesterol impacted the intestinal B cell response.
[Immunity] |
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| Investigators observed high expression of RAN binding protein 1 (RANBP1) in colorectal cancer (CRC) tissues. In vitro and in vivo functional experiments demonstrated that RANBP1 promoted the proliferation and invasion of CRC cells and inhibited the apoptosis of CRC cells.
[Oncogene] |
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| To identify genetic vulnerabilities of colon cancer, investigators performed targeted CRISPR dropout screens comprising 657 Drugbank targets and 317 epigenetic regulators on two patient-derived colon cancer stem cells-enriched spheroids.
[Oncogene] |
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| Researchers investigated the role of the CDK inhibitor p27kip1 in the response to the selective CDK4/6-inhibitor Palbociclib, in colorectal cancer.
[Cell Death & Disease] |
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| Through an LC–MS assay, LIM and SH3 protein 1 (LASP1) was identified as a sphingolipid-metabolism-involved protein, and short-chain enoyl-CoA hydratase (ECHS1) was identified as a new LASP1-interacting protein through a protein assay in colorectal cancer.
[Cell Death & Disease] |
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| To investigate how AHA1 expression regulated the cancer cell progression and/or metastasis of human colorectal cancer (CRC), the expression levels of AHA1 and Hsp90 were examined in 105 CRC tissue samples and compared with those in paired normal tissue.
[Scientific Reports] |
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| Investigators performed an integrated analysis of miRNA and RNA sequencing data to identify a network of interactions within small intestinal epithelial cells which could promote gut barrier disruption.
[Scientific Reports] |
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| Researchers evaluated the anticancer effect of Podophyllotoxin on human colorectal cancer HCT116 cells and identified the detailed molecular mechanism.
[Biomolecules & Therapeutics] |
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| Scientists investigated the effects of hepcidin on iron and calcium uptake ability under physiological, iron uptake stimulation and calcium uptake suppression.
[PLoS One] |
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| Researchers analyzed the suitability of in vitro models for assessing the interaction of micro- and nanoplastics with intestinal cells.
[Environment International] |
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| Aluminum treatment can regulate intestinal composition and bio-enzyme activity, impairing the function of chemical barrier.
[Chemosphere] |
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| First Wave BioPharma, Inc. announced that it has dosed the first patient in a Phase IIb clinical trial investigating a topical formulation of niclosamide as a potential treatment for patients with ulcerative proctitis and ulcerative proctosigmoiditis.
[First Wave BioPharma, Inc.] |
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| November 8 – 10, 2021
Virtual |
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| Brigham and Women’s Hospital and Harvard Medical School – Boston, Massachusetts, United States |
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| | University of Manitoba – Winnipeg, Manitoba, Canada |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Dalhousie University – Halifax, Nova Scotia, Canada |
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| The University of New Mexico – Albuquerque, New Mexico, United State |
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