Intestinal Cell News Volume 7.45 | Nov 26 2021

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    Justin.choi
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    2021-11-26 | ICN 7.45


    Intestinal Cell News by STEMCELL Technologies
    Vol. 7.45 – 26 November, 2021
    TOP STORY

    The Interaction between S100A2 and KPNA2 Mediates NFYA Nuclear Import and Is a Novel Therapeutic Target for Colorectal Cancer Metastasis

    Scientists identified a S100A2/KPNA2 cotransport complex that transported the tumor-associated transcription factor NFYA in colorectal cancer.
    [Oncogene]

    Abstract

    Organoids: Experts Talk Standardization at Nature Research Round Table
    PUBLICATIONSRanked by the impact factor of the journal

    Interactions between Gastric Microbiota and Metabolites in Gastric Cancer

    Researchers characterized the gastric microbiome and metabolome profiles of 37 gastric cancer tumor tissues and matched non-tumor tissues using 16s rRNA gene sequencing and ultrahigh performance liquid chromatography tandem mass spectrometry, respectively.
    [Cell Death & Disease]

    Full Article

    USP39 Attenuates the Antitumor Activity of Cisplatin on Colon Cancer Cells Dependent on p53

    The authors revealed that USP39 was associated with colon cancer cells sensitivity to cisplatin. Depletion of USP39 enhanced the cisplatin-induced apoptosis in HCT116 cells.
    [Cell Biology and Toxicology]

    AbstractGraphical Abstract

    Disruption of Beta-Catenin Dependent Wnt Signaling in Colon Cancer Cells Remodels the Microenvironment to Promote Tumor Invasion

    Overactive Wnt signaling promotes tumor progression from early initiation stages to the later stages including invasion and metastasis. Scientists tested this assumption by reducing the activity of ß-catenin-dependent Wnt signaling in colon cancer cell lines at an upstream or downstream step in the pathway.
    [Molecular Cancer Research]

    Abstract

    The Modulating Effect of Methoxy-Derivatives of 2′-Hydroxychalcones on the Release of IL-8, MIF, VCAM-1 and ICAM-1 by Colon Cancer Cells

    Researchers evaluated the effect of methoxy-derivatives of 2’-hydroxychalcones: 2’-hydroxy-3”-methoxychalcone, 2’-hydroxy-2”-methoxychalcone and 2’-hydroxy-4”-metoxychalcone at the concentrations of 10 µM and 25 µM on the release of IL-8, MIF, VCAM-1, ICAM-1 by colon cancer SW480 and SW620 cell lines.
    [Biomedicine & Pharmacotherapy]

    Full Article

    Fraxetin Induces Cell Death in Colon Cancer Cells via Mitochondria Dysfunction and Enhances Therapeutic Effects in 5-Fluorouracil Resistant Cells

    Investigators used two colon cancer cell lines, HT29 and HCT116 cells, to investigate whether fraxetin could inhibit the capabilities acquired during tumor development. Fraxetin suppressed cell viability and induced apoptotic cell death in HT29 and HCT116 cells.
    [Journal of Cellular Biochemistry]

    Abstract

    ZRANB1 Enhances Stem-Cell-Like Features and Accelerates Tumor Progression by Regulating Sox9-Mediated USP22/Wnt/β-Catenin Pathway in Colorectal Cancer

    Scientists examined the regulatory effects of tumor necrosis factor receptor-associated factor-binding domain, ZRANB1 on the maintenance of cancer stem cell properties and tumor growth in colorectal cancer.
    [Cellular Signalling]

    Abstract

    Curcumin Induces Apoptosis through Caspase Dependent Pathway in Human Colon Carcinoma Cells

    The authors investigated the apoptotic effects of curcumin in the colon carcinoma cell line SW480. Cells were treated with 40–200 μM curcumin for 24, 48, and 72 hours, and the IC50 values were determined for each time interval.
    [Molecular Biology Reports]

    Abstract

    Peroxiredoxin-6 Regulates p38-Mediated Epithelial–Mesenchymal Transition in HCT116 Colon Cancer Cells

    Investigators used peroxiredoxin (Prx)-6 overexpressed and downregulated HCT116 cells to study the mechanism between Prx6 and colon cancer.
    [Journal of Biological Research-Thessaloniki]

    Full Article

    Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.
    REVIEWS

    Circular RNA: A Promising New Star for the Diagnosis and Treatment of Colorectal Cancer

    The authors provide a brief review based on the source, structural characteristics, mechanisms, biological functions of circular RNAs, and the relationships between colorectal cancer.
    [Cancer Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    Relief Reports That Its US Collaboration Partner Has Announced the US FDA Has Denied Breakthrough Designation for Aviptadil

    RELIEF THERAPEUTICS, reported that the parent company of its collaboration partner, NRx Pharmaceuticals, Inc., has issued a CEO update announcing that the US FDA has denied Breakthrough Therapy Designation for aviptadil.
    [Relief Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    AACR: Cancer Metastasis

    January 9 – 12, 2022
    Portland, Oregon, United States

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cancers and Infections

    Lund University – Malmö, Sweden

    Professor – Gut-Liver Axis

    KU Leuven – Leuven, Belgium

    Postdoctoral Fellow – Bioinformatics

    University Medical Center Schleswig-Holstein – Kiel, Germany

    Postdoctoral Fellow – Epithelial Cell Physiology

    University of Houston – Houston, Texas, United States

    Postdoctoral Fellow – Intestinal Homeostasis

    University of North Dakota – Grand Forks, North Dakota, United States

    > See All Jobs

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