 | | Vol. 7.46 – 3 December, 2021 |
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| The composition of the intestinal microbiota is associated with both the development of tumors and the efficacy of anti-tumor immunity. Researchers examined the impact of microbiota-specific T cells in anti-colorectal cancer immunity.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that Cldn18 tumors accurately recapitulated advanced human gastric cancer in terms of disease morphology, aberrant gene expression, molecular markers and sites of distant metastases.
[Nature Cell Biology] |
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| Researchers reported that food amount was a positive determinant of the gut surface area contributing to an increased absorptive function, reversible by reducing daily food.
[Nature Communications] |
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| It was widely assumed that SMAD4-mutant (SMAD4mut) cancer cells were unable to undergo epithelial-mesenchymal transition (EMT). The authors scrutinized this notion and probed for potential SMAD4-independent EMT execution using SMAD4mut colorectal cancer cell lines.
[Oncogene] |
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| Scientists found that both Sirtuin 1 (SIRT1) and SIRT1 phosphorylated on serine 27 were coordinately upregulated in colon cancer patients’ tissues and human colon cancer cell lines.
[Molecular Oncology] |
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| miR-375-3p, the pulmonary tuberculosis specific marker was found in higher amount in the plasma of intestinal tuberculosis patients than Crohn’s disease while reverse expression was observed in the ileocaecal/terminal ileal tissues of the same patients.
[Scientific Reports] |
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| Researchers studied IL-8 secretion, as a marker of pro-inflammatory response through the Toll-like receptor (TLR) pathway, in a Caco-2 monoculture, Caco-2/HT29-MTX di-culture, Caco-2/HT29-MTX/HMVEC-d tri-culture and in a HT29-p monoculture in response to exposure to various TLR agonists.
[Toxicology in Vitro] |
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| Valerate, a short-chain fatty acids mainly converted from proteins or amino acids, was demonstrated to promote intestinal barrier function at its physiological concentrations of 0–4 mM in the Caco-2 cell monolayer model of intestinal barrier.
[Molecular Biology Reports] |
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| Scientists investigated the regulatory function of microRNA miR-145-5p in colon cancer (CC) cells. Bioinformatics analysis was used to screen key genes in CC.
[Bioengineered] |
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| The authors outline the current challenges and forthcoming research perspective for high performance and fostering advanced magnetic nanoparticles in colorectal cancer treatment.
[Journal of Nanobiotechnology] |
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| Scientists summarize the changes brought about by the changes of commensal bacteria to the inflammation of the intestines and their mutual influence.
[Frontiers in Immunology] |
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| Medtronic Canada ULC, announced that it has received a Health Canada licence for the GI Geniusâ„¢ intelligent endoscopy module. GI Genius is a computer-aided detection system that uses artificial intelligence to highlight regions of the colon suspected to have visual characteristics consistent with different types of mucosal abnormalities.
[Medtronic Canada ULC (BioSpace, Inc.)] |
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| December 5 – 9, 2021
Jupiter, Florida, United States |
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| Technical University of Denmark – Lyngby, Denmark |
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| Lund University РMalm̦, Sweden |
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| KU Leuven – Leuven, Belgium |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | University of Houston – Houston, Texas, United States |
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