 | | Vol. 8.00 – 7 January, 2022 |
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| Scientists developed approaches for specifying the initial organoid geometry to build intestinal organoids of defined shape, size, and cell distributions, forming structures that were predictable, more similar to normal organs, and reproducible.
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that propionate suppressed colorectal cancer growth by promoting the proteasomal degradation of euchromatic histone-lysine N-methyltransferase 2 (EHMT2) through HECT domain E3 ubiquitin protein ligase 2 (HECTD2) upregulation.
[ISME Journal] |
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| Scientists showed that Gpr17, an orphan G protein-coupled receptors, was co-expressed in glucagon-like peptide-1 (GLP-1)-expressing EECs in human and rodent intestinal epithelium.
[Cell Reports] |
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| Researchers investigated the effects of curcumin treatment on cisplatin-resistant colorectal cancer cells. Expression levels of miRNAs and mRNAs were determined by qRT-PCR. Protein expression levels were detected by Western blotting.
[Current Medicinal Chemistry] |
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| Investigators analyzed Clinical Proteomic Tumor Analysis Consortium, colon tissue microarray, and colon cancer cells to evaluate the ESRP1 expression levels in colorectal cancer subtypes.
[Cellular Signalling] |
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| The expression and effect of miR‑1291 in colorectal cancer cells (CRC) was investigated. It was identified that miR‑1291 significantly suppressed the proliferation, invasion, cell mobility and colony formation of CRC cells.
[International Journal of Oncology] |
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| Scientists analyzed the effects of Ginkgo biloba extract (GBE) administration on TET2 expression in human colorectal cancer (CRC). To investigate the expression profiles of TET2, GBE was used to treat CRC cells.
[DNA and Cell Biology] |
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| The authors investigated the antitumor effects of Ailanthone on HCT116 and SW620 colon cancer cells, and to analyze the underlying molecular mechanisms.
[International Journal of Molecular Medicine] |
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| A small molecule EHMT-2 inhibitor, BIX-01294, was evaluated for its activity in inhibiting cancer stem cells in human colorectal cancer by in vitro and in vivo experiments.
[Biochemical and Biophysical Research Communications] |
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| To determine whether certain herbal preparations containing coumarin might cause damage to the intestinal epithelium, Caco2 cells were exposed to common phytochemicals. Coumarin, astragaloside IV or atractylenolide I solutions were exposed to Caco2 cultures in increasing concentrations, individually or combined.
[Drug and Chemical Toxicology] |
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| IL-21 has profound effects on tumor growth and immunosurveillance of colitis-associated tumourigenesis, thereby emphasising its involvement in the pathogenesis of colorectal cancer.
[Molecular Biology Reports] |
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| The authors discuss strategies and open questions for mining and biomimicking the microbial metabolite-targetome interactions for pharmacological manipulation, which may lead to a new paradigm of drug discovery.
[Cell Metabolism] |
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| First Wave BioPharma, Inc. announced that it has completed enrollment for Part II of the RESERVOIR Phase II trial evaluating FW-COV as an outpatient treatment for COVID-19-related gastrointestinal infections.
[First Wave BioPharma, Inc.] |
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| February 10 – 12, 2022
Lorne, Victoria, Australia |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| Princess Margaret Cancer Centre – Toronto, Ontario, Canada |
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| KU Leuven – Leuven, Belgium |
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| Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States |
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Cancer Stem Cell News
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