 | | Vol. 8.04 – 4 February, 2022 |
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| Researchers used multiple conditional deletion models to identify a role for IL-17A in secretory epithelial cell differentiation in the gut.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors provided a reproducible protocol to robustly induce intestinal morphogenesis in a microfluidic gut-on-a-chip as well as in a transwell-embedded hybrid chip.
[Nature Protocols] |
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| Scientists suggested that hematopoietic TNF-α-induced protein 8-like 2 (TIPE2) regulated intestinal anti-tumor immunity by regulation of gut microbiota. TIPE2 may represent a new therapeutic target for treating colorectal cancer.
[Cancer Immunology Research] |
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| Investigators uncovered a novel antiviral function of N6-methyladenosine (m6A) modification during rotavirus infection in small bowel intestinal epithelial cells.
[eLife] |
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| The authors developed a method for live-cell imaging of microbial infection dynamics on human adult stem cell-derived intestinal epithelial cell layers.
[mBio] |
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| Researchers investigated the effects of a cranberry proanthocyanidin-rich extract and two of its gut microbial metabolites, 3,4-dihydroxyphenylacetic acid and 3-(4-hydroxyphenyl)-propionic acid, on intestinal epithelial cells microRNA expression.
[Molecular Nutrition & Food Research] |
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| Scientists analyzed the genotoxicity and the intracellular reactive oxygen species induction by physiologically relevant concentrations of three different titanium dioxide nanomaterials in Caco-2 and HT29-MTX-E12 intestinal cells.
[Food and Chemical Toxicology] |
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| Investigators screened the actions of botanical extracts intended for oral use on human adipose tissue, using an in vitro screening model combining human intestinal cells with human adipose cells.
[European Journal of Nutrition] |
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| Scientists demonstrated that S. Typhimurium virulence plasmid (pSLT) promoted necroptosis of intestinal epithelial cells and contributed to the destruction of the intestinal barrier during Salmonella infection.
[Cell Death Discovery] |
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| Researchers explored if omega-3 fatty acids could affect sepsis-induced intestinal injury with the involvement of the microRNA-1-3p/Notch3-Smad axis.
[Molecular Medicine] |
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| The authors demonstrate the roles and mechanisms of gastrointestinal polypeptides, especially somatostatin and vasoactive intestinal peptide, in intestinal barrier regulation.
[Peptides] |
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| Tiziana Life Sciences Ltd announced submission of an amendment to an Investigational New Drug application for evaluation of orally administered capsules of foralumab, which it believed would be the first “take home” immunotherapy, in patients with mild-to-moderately active Crohn’s Disease.
[Tiziana Life Sciences Ltd] |
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| April 4 – 8, 2022
Saint Malo, France |
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| | Umeå University – Umeå, Sweden |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | University of North Dakota – Grand Forks, North Dakota, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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