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Vol. 8.22 – 17 June, 2022
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Researchers showed that caspase-7-deficient intestinal epithelial cells did not complete extrusion in both organoids and mice.
[Nature]
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PUBLICATIONSRanked by the impact factor of the journal
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Nanoparticles conjugated with the cytostatic drug doxorubicin and a fluorescent dye exhibited significantly greater cytotoxicity toward CT-26 tumor spheroids than equally concentrated dissolved doxorubicin.
[Small]
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Investigators established that autophagy was required for ileum PDGFRA/PDGFRα+ mesenchymal cell metabolism, stem cell maintenance, and mammalian survival.
[Autophagy]
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The authors investigated the function of circMETTL3/miR-107/PER3 in colorectal cancer (CRC), using human CRC tissues from diagnosed CRC patients, six CRC cell lines, and one normal human colon cell line.
[Cell Death & Disease]
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Scientists found the NAIP/NLRC4 inflammasome was dispensable for early inflammasome responses to Salmonella in both human intestinal epithelial cell lines and enteroids.
[Infection and Immunity]
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Researchers assessed the reversal potential of Curcumae longae Rhizoma extract in 5-Fluorouracil resistance to colon cancer and explored its underly mechanism.
[Clinics and Research in Hepatology and Gastroenterology]
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Scientists investigated a paradoxical in vivo effect of taurolidine and closely analyzed the interaction of cancer cells with the surrounding environment following taurolidine exposure.
[BMC Pharmacology and Toxicology]
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Investigators assessed the role of inhibin A (INHBA) in the proliferation along with the migration of colon cancer cells.
[Journal of Clinical Laboratory Analysis]
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The authors review endogenous and exogenous factors in gut homeostasis, such as caloric restriction, fasting, fat, glucose, and trace element.
[Critical Reviews in Food Science and Nutrition]
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The formation of artificial wounds in a controlled environment allows for the exploration of reparative physiology in cell lines modeling diverse aspects of intestinal physiology.
[Tissue Barriers]
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G1 Therapeutics, Inc. announced that the last patient has been randomized in the Phase III clinical trial of trilaciclib for patients with metastatic CRC receiving chemotherapy.
[G1 Therapeutics, Inc.]
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AbbVie announced that the US FDA has approved SKYRIZI® as the first and only specific IL-23 inhibitor for the treatment of adults with moderately to severely active Crohn’s disease.
[AbbVie]
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December 8 – 10, 2022
Los Angeles, California, United States
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European Molecular Biology Laboratory – Heidelberg, Germany
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University Hospital of Würzburg – Würzburg, Germany
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University of North Dakota – Grand Forks, North Dakota, United States
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Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States
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Flanders Institute for Biotechnology – Ghent, Belgium
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