 | | Vol. 8.30 – 19 August, 2022 |
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| To trace the fate of human colonic stem or differentiated cells, scientists generated LGR5-tdTomato, LGR5-iCT, LGR5-split-Cre, and KRT20-ERCreER knock-in human colon organoids via genome engineering.
[Gastroenterology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that specific microbiota members altered epithelial homeostasis by increasing epithelial turnover rate, crypt proliferation, and major histocompatibility complex class II expression.
[Cell Host & Microbe] |
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| Researchers showed that upregulated DExD-box helicase 39B (DDX39B) correlated with liver metastases and aggressive phenotypes in colorectal cancer.
[Signal Transduction and Targeted Therapy] |
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| Investigators demonstrated that mannose treatment enhanced lysosomal integrity and limited the release of cathepsin B, preventing mitochondrial dysfunction and myosin light chain kinase-induced tight junction disruption in the context of intestinal epithelial damage
[Nature Communications] |
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| Scientists revealed the pathogenic mechanism of NDUFA4 in gastric cancer (GC). NDUFA4 expression was explored in single-cell and bulk RNA-seq data as well as GC tissue microarray.
[Cell Death & Disease] |
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| Researchers found that H. pylori and cytotoxin-A (CagA) downregulated deleted-in-liver-cancer-1 (DLC1v1/4) promoter activities, and that DLC1v1/4 inhibited cell migration and counteracted CagA-driven stress phenotypes enforcing focal adhesion.
[Cell Death Discovery] |
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| The authors investigated the effects of titanium dioxide food grade exposure after being removed from colon cell cultures.
[Toxicology] |
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| Investigators used human induced pluripotent stem cell (iPSC)-derived intestinal epithelial cells, grown as a cell layer, to study the effects of butyrate, propionate, and acetate on whole genome gene expression in the cells.
[Scientific Reports] |
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| The non-psychoactive phytocannabinoid cannabidiol significantly inhibited proliferation, migration, and invasion of colon cancer cells in a dose- or time-dependent manner.
[Journal of Cancer Research and Clinical Oncology] |
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| Scientists investigated the hypothesis that inhibition of PAKs with IPA-3 and PF-3758309 treatment could synergistically reduce colon carcinoma cell growth.
[International Journal of Radiation Biology] |
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| At the interface between the host and the microbiota, alterations in the host innate immune system and in circulating soluble factors that regulate iron are associated with metabolic disease.
[Nature Reviews Endocrinology] |
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| Arbele, a clinical stage biopharmaceutical company, announced the successful dosing of the first patient in Australia in Phase I Study of ARB202, for the treatment of advanced gastrointestinal cancers patients.
[Arbele] |
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| Innovative Cellular Therapeutics, Inc. announced that the first patient has been enrolled in its Phase I trial of GCC19CART for relapsed/refractory metastatic colorectal cancer.
[Innovative Cellular Therapeutics, Inc.] |
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| October 3 – 5, 2022
Vancouver, British Columbia, Canada |
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| | Washington University in St. Louis – St. Louis, Missouri, United States |
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| | Duke University – Durham, North Carolina, United States |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | University of California Santa Cruz – Santa Cruz, California, United States |
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| | Dalla Lana School of Public Health – Toronto, Ontario, Canada |
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