Intestinal Cell News Volume 8.38 | Oct 28 2022

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    Jamie Kang
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    2022-10-28 | ICN 8.38


    Intestinal Cell News by STEMCELL Technologies
    Vol. 8.38 – 28 October, 2022
    TOP STORY

    DNA Methyltransferase 3A Controls Intestinal Epithelial Barrier Function and Regeneration in the Colon

    Scientists presented that DNA methyltransferase 3A played a critical role in maintaining intestinal homeostasis and gut barrier function and found downregulated expression in intestinal epithelial cells from IDB patients and upon tumour necrosis factor treatment in murine intestinal organoids.
    [Nature Communications]

    Full Article
    GI Organoid Applications
    PUBLICATIONSRanked by the impact factor of the journal

    High-Fat Diet Induced Cyclophilin B Enhances STAT3/lncRNA-PVT1 Feedforward Loop and Promotes Growth and Metastasis in Colorectal Cancer

    Investigators showed that high fat diet-induced Cyclophilin B (CypB) enhanced proliferation and metastasis through an inflammation-driven circuit, as well as its binding with CypB that promoted activation of signal transducer and activator of transcription 3 (STAT3).
    [Cell Death & Disease]

    Full Article

    Sohlh2 Regulates the Stemness and Differentiation of Colon Cancer Stem Cells by Downregulating LncRNA-H19 Transcription

    Researchers demonstrated that Sohlh2 was related to the inhibition of LncRNA-H19/miR-141/β-catenin signaling and led to the consequent suppression of colon cancer stem cell (CSC) stemness and the promotion of colon CSC differentiation in vitro and in vivo.
    [Molecular Cancer Research]

    Abstract

    Deletion of Smad7 Ameliorates Intestinal Inflammation and Contributes to Fibrosis

    Investigators evaluated the effect of Smad7 deficiency on inflammation, fibrogenesis, and wound healing in specific settings of IBD.
    [Inflammatory Bowel Diseases]

    Abstract

    Differential Response to the Course of Cryptosporidium parvum Infection and Its Impact on Epithelial Integrity in Differentiated versus Undifferentiated Human Intestinal Enteroids

    Scientists utilized previously developed stem cell-derived human intestinal enteroid models for Cryptosporidium parvum which was used to investigate the course of infection and its effect on intestinal epithelial integrity.
    [Parasitology]

    Abstract

    Correlation between Copper Speciation and Transport Pathway in Caco-2 Cells

    Intracellular accumulation of copper derived from copper ion and copper complex solutions was investigated in Caco-2 cells to study whether different speciations shared the same transport pathway in intestinal epithelial cells.
    [Journal of the Science of Food and Agriculture]

    Abstract

    Prenatal Stress Induces Changes in PAR2- and M3-Dependent Regulation of Colon Primitive Cells

    Investigators studied the proliferative and differentiation capacities of primitive cells using epithelial crypts isolated from colons of adult male and female mice whose mothers have been stressed during late gestation.
    [Journal of Gastrointestinal and Liver Diseases]

    Abstract

    An ISSCR 2022 COREdinates Webinar: Differentiation of High-Quality hPSCs Using STEMdiff â„¢ and TeSR â„¢-AOF, presented by Kim Snyder. Click to Watch Now.
    REVIEWS

    Kelch-Like Proteins in the Gastrointestinal Tumours

    The authors summarize the current knowledge of kelch-like (KLHL) proteins in gastrointestinal tumors and discuss the potential of KLHL proteins as potential drug targets and prognostic biomarkers.
    [Acta Pharmacologica Sinica]

    Abstract
    INDUSTRY AND POLICY NEWS

    Takeda Enters Collaboration and Licensing Agreement with Zedira and Dr. Falk Pharma to Develop First-in-Class Celiac Disease Therapy

    Takeda, Zedira, and Dr. Falk Pharma GmbH announced a collaboration and licensing agreement to develop ZED1227/TAK-227, a Phase IIb investigational therapy for the treatment of celiac disease.
    [Zedira GmbH]

    Press Release
    FEATURED EVENT

    Neuroscience 2022

    November 12 – 16, 2022
    San Diego, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Intestinal Organoids

    University of Copenhagen – Copenhagen, Denmark

    Postdoctoral Position – Advanced Tumoroid Biology

    Ludwig Maximilians University of Munich – Munich, Germany

    Postdoctoral Associate – Inflammatory Bowel Diseases

    Duke University – Durham, North Carolina, United States

    Postdoctoral Position – Epigenetics in Beta-Cell Maturation and Function

    University of Southern Denmark – Odense, Denmark

    Associate Scientist – Bioscience Immunology

    AstraZeneca – Gaithersburg, Maryland, United States

    > See All Jobs

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