 | | Vol. 8.39 – 4 November, 2022 |
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| Investigators presented that epithelial and mesenchymal isoform switches of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) regulated by epithelial splicing regulatory protein 1 (ESRP1) correlated with the metastatic potential of gastric cancer cells.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In order to investigate the role of molecular chaperones in driving colorectal cancer initiation, scientists captured the transcriptomic profiles of murine wild type and Apc-mutant organoids during active transformation.
[EMBO Molecular Medicine] |
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| Investigators found that the loss of Myosin Vb interfered with the differentiation/polarization of colorectal cancer cells. Although modulation of Myosin Vb expression did not affect the proliferation of colon cancer cells, MYO5B inactivation increased their migration, invasion, and metastatic potential.
[Oncogene] |
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| Researchers corroborated the involvement of primary cilia in colonic pathologies by employing relevant mouse models and analyzing patients’ biopsies.
[EMBO Reports] |
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| Investigators developed a zebrafish Feingold syndrome type 1 model with nonfunctional mycn, which had severe intestinal atresia.
[PLoS Biology] |
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| Researchers characterized the presence of desmosomal plaque proteins plakophilins (PKPs) in the human intestine and in different in vitro models to assess the basic contribution of PKPs in the context of intestinal epithelial barrier regulation.
[Tissue Barriers] |
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| Scientists analyzed the 5-fluorouracil (FU) response in patient-derived organoids that reproduced the different stages of colorectal cancer and found that 5-FU induced pyrimidine imbalance, which led to DNA damage and cell death in the actively proliferating cancer cells deficient in p53.
[Communications Biology] |
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| Researchers investigated the physiological role of short-chain fatty acids (SCFAs) on intestinal Mg2+ by elucidating the molecular mechanisms by which SCFAs modulate Mg2+ uptake in the human colon cell line Caco-2.
[Scientific Reports] |
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| The authors explore the clinical trials regarding dietary fibers and colorectal cancer, thus indicating the potential anti-cancer effects of pectins and modified pectins.
[Food & Function] |
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| Investigators provide a detailed description of the role of polysaccharides used as a therapeutic agent and as a formulation pertaining to gastrointestinal diseases.
[Chemico-Biological interactions] |
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| VectivBio Holding AG announced the completion of enrollment of the Colon-in-Continuity cohort for the company’s Phase III STudy of ApRglutide in SBS (STARS) pivotal study investigating the long-acting synthetic GLP-2 agonist apraglutide in Short Bowel Syndrome with Intestinal Failure.
[Vective Bio Holding AG] |
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| First Wave BioPharma, Inc. announced that it has entered into an agreement with Rho, a full-service contract research organization, for its planned Phase II clinical trial of an enhanced enteric microgranule delivery formulation for adrulipase.
[First Wave BioPharma, Inc.] |
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| December 5 – 7, 2022
Virtual |
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| | University of North Carolina – Chapel Hill, North Carolina, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Quadram Institute Bioscience – Norwich, England |
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| | Ludwig Maximilians University of Munich – Munich, Germany |
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| | Duke University – Durham, North Carolina, United States |
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