 | | Vol. 8.40 – 18 November, 2022 |
| |
|
|
| Investigators demonstrated that chemotherapy-induced tumor cell death in patient-derived colorectal tumor organoids caused ATP release triggering P2X4 to mediate an mTOR-dependent pro-survival program in neighboring cancer cells, which rendered surviving tumor epithelia sensitive to mTOR inhibition.
[Nature] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers uncovered the identity and features of the residual tumor cells responsible for colorectal cancer relapse.
[Nature] |
|
|
|
| Scientists found that colorectal cancer tumors highly infiltrated by neutrophils contained a population of CD8+ T effector memory cells characterized by high levels of Granzyme K, which led to a worse prognosis.
[Nature Communications] |
|
|
|
| Researchers examined whether oncogene inhibitor of apoptosis stimulating protein of p53 (iASPP) regulated the adaptation-death switch and how the mechanisms could be used in colon cancer treatment.
[Cell Death & Differentiation] |
|
|
|
| Scientists investigated proliferation-prompting functions and mechanisms of EXOSC8 in colorectal cancer by performing in silico analysis and wet-lab experiments.
[Oncogene] |
|
|
|
| The authors reported that CXCL16 was up-regulated in the injured intestinal tissues of radiation enteritis patients and in a mouse model.
[Journal of Pathology] |
|
|
|
| Researchers revealed that Ras-related C3 botulinum toxin substrate 1 (Rac1) was highly expressed in colon cancer tissues and cell lines. Rac1 promoted the proliferation, migration, and invasion of colon cancer cells by upregulating SOX9.
[Cancer Science] |
|
|
|
| Investigators found enhancer release and retargeting (ERR) event activated GPR35 resulted in gastric cancer cells proliferation and migration, and partly immune cells significance exhaustion and/or infiltration.
[Cell Death Discovery] |
|
|
|
| Scientists examined the association between mitophagy-related genes and the prognosis of colorectal cancer patients.
[Scientific Reports] |
|
|
|
| The expression level of ribosomal protein L5 (RPL5) in colon cancer tissues and cell lines was significantly higher than that in adjacent tissues and NCM460 cells, respectively, and its expression level was higher in HCT116 cells and RKO cells.
[BMC Molecular and Cell Biology] |
|
|
|
| Researchers established a robust differentiation method into suspension-cultured human intestinal organoids by seeding dissociated cells on a spheroid-forming plate.
[Cell Reports Methods] |
|
|
|
|
| Scientists review and discuss the significance of in vivo studies which used the Drosophila gut to identify conserved pathways that link regulators of Ca2+, Na+, and Cl– with intestinal stem cell roliferation.
[Trends in Cell Biology] |
|
|
|
| The authors discuss the normal development and function of the intestinal epithelium in early life as well as how disruption of these processes can lead to necrotizing enterocolitis.
[Mucosal Immunology] |
|
|
|
| Investigators summarize the genetically engineered mouse models in which Kirsten rat sarcoma viral oncogene homolog (Kras) is activated with cell-type and/or tissue-type specificity that are utilized for studying carcinogenic processes in gastric cancer as well as pancreatic cancer and colorectal cancer.
[Experimental & Molecular Medicine] |
|
|
|
|
| Applied Molecular Transport, Inc. announced that the US FDA has granted Orphan Drug Designation for AMT-101 in patients with pouchitis, an indication with significant unmet medical needs and no current FDA-approved products.
[Applied Molecular Transport, Inc.] |
|
|
|
| Organovo Holdings, Inc. announced that it has successfully advanced the use of its first inflammatory bowel disease model and has achieved the next milestone, target validation.
[Organovo Holdings, Inc.] |
|
|
|
|
| December 7 – 9, 2022
Geneva, Switzerland |
|
|
|
|
|
| | Philipps-University Marburg – Marburg, Germany |
|
|
|
| | International Agency for Research on Cancer, WHO – Lyon, France |
|
|
|
| | Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
|
|
|
| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
